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Dietary supplement

DIM Diindolymethane 400 mg Ingredients & Drug Interactions

by Double Wood Supplements

DIM Diindolymethane 400 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM Diindolymethane 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM Diindolymethane 400 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DIM Diindolymethane 400 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM Diindolymethane 400 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DIM Diindolymethane 400 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

The single active ingredient is diindolylmethane, 400 mg per capsule. It is the ingredient we have interaction and effectiveness data on, and it is the reason this product is listed with the interactions above.

The capsule also contains two inactive ingredients, hypromellose and rice flour, which are included as fillers or capsule materials rather than as active components.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Energy, metabolism, and balance.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Diindolylmethane has been studied for benign prostatic hyperplasia (enlarged prostate), breast cancer, colorectal cancer, cervical dysplasia (abnormal cell changes on the cervix), and mastalgia (breast pain). For every one of these uses, our data rates the evidence as insufficient reliable evidence to rate.

In plain terms, we do not have enough solid research to say whether this product works for any of these purposes.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in short-term studies, but long-term safety is not well established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting.

A serious skin reaction called drug rash with eosinophilia and systemic symptoms (DRESS) is listed as rare. One case report linked diindolylmethane to ischemic stroke (a stroke caused by blocked blood flow) in a patient who had several other risk factors, so it is unclear whether diindolylmethane contributed.

Our safety notes advise that it is best avoided because safety data is limited and it may affect hormones.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check estrogens (female sex hormones) and diuretics (water pills), both rated Moderate, before taking this product. Also check medications cleared by the CYP1A2 liver enzyme, rated Minor.

Our data documents these interactions for diindolylmethane, and your own doctor or pharmacist can confirm whether any of them apply to you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be of interest to adults who want to learn more about diindolylmethane, but our data does not establish that it works for any purpose. If you take estrogens, diuretics, or medications cleared by the CYP1A2 liver enzyme, or if you have a hormone-sensitive condition, be especially careful.

Talk it over with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM Diindolymethane 400 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 850033272758
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 315645
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM Diindolymethane 400 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
850033272758
IngredientAmount% DV
Diindolylmethane400 mg--

Other ingredients: Hypromellose, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Product Information: Diindolylmethane is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.

DIM 400 mg per serving

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take 1 serving per day, with or without food.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature after opening.

Seals/Symbols

Proudly manufactured in the USA

Formulation

Made with Non GMO Ingredients Gluten Free

Energy, metabolism, balance

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult your physician before use. Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use DIM and operate heavy machinery until you know how it affects you. Do not exceed capsules per day.

Do not use DIM if you are pregnant, nursing, or are under 18 years of age.

Do not use DIM if you are pregnant, nursing, or are under 18 years of age.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM Diindolymethane 400 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM Diindolymethane 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM Diindolymethane 400 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Diindolylmethane

Interacts with
269 drugs
400 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM Diindolymethane 400 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against DIM Diindolymethane 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

Diindolylmethane 269

Individual Drug Interactions

The ingredients in DIM Diindolymethane 400 mg interact with 269 drugs. Click any drug to see the details.

1 of the 1 ingredient in DIM Diindolymethane 400 mg interact with drugs. Each result below shows which ingredient is responsible. Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM Diindolymethane 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM Diindolymethane 400 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
205 Elmwood Ave
City
Sharon Hill
State
PA
ZipCode
19079
Pharmacist Counseling Corner

DIM Diindolymethane 400 mg by Double Wood Supplements: Common Questions

Does DIM Diindolymethane 400 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, DIM Diindolymethane 400 mg has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM Diindolymethane 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is DIM Diindolymethane 400 mg safe to take while pregnant or breastfeeding?
Our pregnancy and lactation entry rates it as likely safe, but a separate safety note advises avoiding it while breastfeeding because there is no reliable safety information. Because the data points in different directions, please talk with your own doctor or pharmacist for personalized advice before using it.
What are the side effects of diindolylmethane?
The most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting. A serious skin reaction called DRESS is rare. Diindolylmethane is generally well tolerated in short-term studies.
Does diindolylmethane work for breast pain or breast cancer?
Our data rates the evidence for both mastalgia (breast pain) and breast cancer as insufficient reliable evidence to rate. That means we do not have enough research to say whether it helps.
What is diindolylmethane used for?
It has been studied for benign prostatic hyperplasia (enlarged prostate), breast cancer, colorectal cancer, cervical dysplasia, and mastalgia (breast pain). For each of these, the evidence is currently insufficient to rate.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM Diindolymethane 400 mg label
Go deeper

The Full Monographs Behind DIM Diindolymethane 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

DIM Diindolymethane 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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