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Dietary supplement

Enduralean Stim Free Pink Lemonade Ingredients & Drug Interactions

by InnovaPharm

Enduralean Stim Free Pink Lemonade label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enduralean Stim Free Pink Lemonade against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Enduralean Stim Free Pink Lemonade is a dietary supplement by InnovaPharm with 2 active ingredients.Based on those ingredients, 1,561 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Enduralean Stim Free Pink Lemonade by InnovaPharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Enduralean Stim Free Pink Lemonade by InnovaPharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Enduralean Stim Free Pink Lemonade by InnovaPharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Mind-Muscle Performance Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Targeted Fat Melting Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Enduralean Stimulant Free Complex” is a proprietary blend — the label gives one combined amount (2,090 mg) without saying how much of each component you get.

Enduralean Stim Free contains 12 active ingredients blended across several proprietary complexes. The main active components include L-Tyrosine (an amino acid for mental clarity), Choline Bitartrate (a compound that supports brain function), Ashwagandha root extract (an adaptogenic herb), Huperzine A (a plant alkaloid that acts on brain chemistry), Coleus forskholii Root Extract (a traditional plant extract), Terminalia arjuna bark extract (a botanical used in traditional medicine), and 13-PPAR (goldthread extract).

The product also includes several branded blends: a Mind-Muscle Performance Blend, a Targeted Fat Melting Matrix, AfraLean (Grains of Paradise), and the Enduralean Stimulant Free Complex. The inactive ingredients are sucralose, erythritol, a bitterness blocker, natural and artificial flavor, citric acid, and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: endurance enhancement and fat loss.
  • We looked for evidence on: Athletic performance, exercise capacity, metabolic rate, body composition.
  • The closest evidence on file: Choline is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Huperzine A is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence behind the ingredients in this product is mixed. L-Tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, though possibly ineffective for athletic performance.

Ashwagandha shows possibly effective evidence for insomnia, anxiety, stress, and generalized anxiety disorder. Huperzine A is possibly effective for Alzheimer disease.

Choline, Terminalia arjuna, Coleus, and 13-PPAR all have insufficient reliable evidence or no established effectiveness ratings in our data for the purposes this product likely targets. Because the product is marketed as a stim-free supplement, we cannot speak to claims about energy or fat loss without effectiveness data on file.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Tyrosine is generally well tolerated in healthy adults but has limited long-term safety data; common side effects in trials included fatigue, headache, heartburn, and nausea. Choline is likely safe in food amounts but is generally safe at supplement doses; high doses (above 3.5 grams daily) may cause fishy body odor, diarrhea, nausea, and sweating.

Ashwagandha is generally well tolerated short-term but has rare serious concerns including acute liver failure—it should be avoided during pregnancy (likely unsafe) and while breastfeeding. Huperzine A is a pharmacologically active compound that causes dose-dependent cholinergic side effects such as blurred vision, nausea, diarrhea, and vomiting; it should be avoided in pregnancy and breastfeeding.

Coleus may lower blood pressure and is not well studied long-term; avoid during pregnancy. Terminalia arjuna, AfraLean, and 13-PPAR all lack adequate long-term safety data and should be avoided in pregnancy and breastfeeding.

Altogether, these interactions span 1,562 individual medications.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Choline, Goldthread, Huperzine A, Terminalia, Ashwagandha, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,562 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of the following: nitrates or calcium channel blockers (heart medications—Major risk with Coleus); CNS depressants, benzodiazepines, or sedatives (Ashwagandha can increase drowsiness); blood pressure medications or blood thinners (Ashwagandha, Terminalia arjuna, and Coleus may interact); diabetes medications (Ashwagandha may lower blood sugar); thyroid hormones (L-Tyrosine and Ashwagandha may boost levels); levodopa (Parkinson's medication—L-Tyrosine may interfere); cholinergic or anticholinergic drugs (Huperzine A affects these); drugs metabolized by liver enzymes CYP2D6, CYP2C9, or CYP3A4 (Terminalia arjuna, Coleus, and 13-PPAR inhibit these); immunosuppressants (Ashwagandha may reduce effectiveness); or hepatotoxic drugs (Ashwagandha carries liver risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is marketed as a stim-free supplement combining ingredients for mental clarity and metabolic support, but several of its components—especially Ashwagandha, Coleus, and Terminalia arjuna—interact with common medications including heart drugs, blood thinners, diabetes medications, and thyroid hormones. If you take any prescription medication, are pregnant, breastfeeding, or have liver or heart concerns, talk with your doctor or pharmacist before adding this to your routine.

The evidence for effectiveness is strongest for Ashwagandha (anxiety and sleep) and L-Tyrosine (cognitive function) but limited or absent for other ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enduralean Stim Free Pink Lemonade, straight from the product label.

Brand InnovaPharm
Barcode (UPC) 691054772441
Net contents 8.9 Ounce(s); 252 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299152
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enduralean Stim Free Pink Lemonade by InnovaPharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
9 Gram(s)
Servings per container
84
UPC/BARCODE
691054772441
IngredientAmount% DV
Fucoxanthin0 NP--
L-Tyrosine0 NP--
Choline Bitartrate0 NP--
Ashwagandha root extract0 NP--
Alpha-Hydroxyisocaproic Acid0 NP--
Intellectus0 NP--
Mind-Muscle Performance Blend0 NP--
Terminalia arjuna bark extract0 NP--
Targeted Fat Melting Matrix0 NP--
AfraLean0 NP--
Enduralean Stimulant Free Complex2090 mg--
Huperzine A0 NP--
Carnitine Complex0 NP--
Coleus forskholii Root Extract0 NP--
13-PPAR0 NP--

Other ingredients: Sucralose, Erythritol, Bitterness Blocker, Natural and Artificial flavor, Citric Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Enduralean Stim Free is a 100% caffeine & stimulant free endurance enhancing pre-exercise fat burner.

Endurance enhancing fat loss powder

No artificial colors or dyes

Allergen Information: Not manufactured with wheat, gluten, soy, fish, shellfish, egg, milk or tree nut ingredients.

Formula

Enduralean Stim Free contains all of the same non stimulant ingredients found in the original Enduralean but with the addition of Huperzine A, Fucoxanthin, 95% Forskolin, and an ultra potent carnitine complex, making Enduralean Stim Free the ultimate metabolic accelerating performance enhancer for those who may be sensitive to caffeine and other stimulants.

Infused with: AfraLean Carnitine loaded Forskolin & fucoxanthin Pink Lemonade Naturally & Artificially Flavored

Precautions

Warning: This product is only intended to be consumed by healthy adults, 18 years of age or older. Keep out of reach of children.

Do not use this product if you are pregnant or nursing. Before using this product, consult a licensed, qualified, health care professional, including but not limited to, if: you are taking antidepressants such as MAOI (Monoamine Oxidase Inhibitor) or SSRI, blood thinners, nonsteroidal anti-inflammatory drugs, pseudoephedrine, or if you are taking any other dietary supplement, prescription drug or over-the-counter medication; or if, you suspect you have or have been treated for, diagnose with or have a family history of, any medical condition, including but not limited to: high or low blood pressure, diabetes, anxiety, cardiovascular, psychiatric or seizure disorders, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, or difficulty urinating due to prostate enlargement.

Discontinue use 2 weeks prior to surgery. Immediately discontinue use and contact a medical doctor if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing.

Do not exceed 3 servings in any 24 hour period. Use only as directed.

Allergen Information: Not manufactured with wheat, gluten, soy, fish, shellfish, egg, milk or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Consume 1-2 scoops mixed with 8-12 oz of water on an empty stomach, preferably before breakfast. An additional 1 scoop can be taken 6-8 hours later on an empty stomach. For best results, consume before exercise and use daily. Do not exceed 3 servings in any 24 hour period. Use only as directed.

General Statements

Twitter Instagram Facebook Follow Us: @InnovaPharm

Brand IP Statement(s)

AfraLean is a registered trademark of Ayurveda Naturals

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enduralean Stim Free Pink Lemonade by InnovaPharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enduralean Stim Free Pink Lemonade label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enduralean Stim Free Pink Lemonade by InnovaPharm

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container84 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Enduralean Stimulant Free Complex

2090 mg per serving
  • › Mind-Muscle Performance Blend
  • › Targeted Fat Melting Matrix

Other (inactive) ingredients: Sucralose, Erythritol, Bitterness Blocker, Natural and Artificial flavor, Citric Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enduralean Stim Free Pink Lemonade by InnovaPharm Drug Interactions

Want to check YOUR meds against Enduralean Stim Free Pink Lemonade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,561Drugs
29 Major 1,486 Moderate 46 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Enduralean Stim Free Pink Lemonade interact with 1,561 drugs. Click any drug to see the details.

0 of the 2 ingredients in Enduralean Stim Free Pink Lemonade interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Enduralean Stim Free Pink Lemonade with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Enduralean Stim Free Pink Lemonade, from the product label.

InnovaPharm

See all InnovaPharm products
Name
InnovaPharm
Street Address
53 E Merrick Rd. #215
City
Freeport
State
NY
ZipCode
11520
Web Address
InnovaPharm.com
Pharmacist Counseling Corner

Enduralean Stim Free Pink Lemonade by InnovaPharm: Common Questions

Does Enduralean Stim Free Pink Lemonade by InnovaPharm interact with any medications?
Yes. Based on its ingredients, Enduralean Stim Free Pink Lemonade has a known interaction with 1,561 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enduralean Stim Free Pink Lemonade contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while pregnant or breastfeeding?
No. Ashwagandha is likely unsafe in pregnancy, and Coleus, Terminalia arjuna, 13-PPAR, and AfraLean all lack enough safety data to recommend them. Huperzine A should also be avoided. L-Tyrosine and Choline have insufficient data on file for pregnancy, and Choline is higher-need while breastfeeding but should only be used under professional guidance. Talk with your doctor or pharmacist about any supplement before use during pregnancy or nursing.
What does Huperzine A do?
Huperzine A is a plant alkaloid that works on brain chemistry by slowing the breakdown of acetylcholine, a neurotransmitter involved in memory and thinking. It's possibly effective for Alzheimer disease but comes with dose-dependent side effects like blurred vision, nausea, and diarrhea, so it requires careful medical guidance.
Can this product cause liver damage?
Ashwagandha has been linked to rare cases of acute hepatitis and liver failure. While serious liver injury is uncommon, it has happened. If you have liver problems or take other medications that stress the liver, ask your doctor or pharmacist before starting this product.
What are the most common side effects?
L-Tyrosine may cause fatigue, headache, heartburn, or nausea. Ashwagandha can cause diarrhea, nausea, or vomiting (though these are not typical at standard doses). Huperzine A causes dose-dependent side effects including blurred vision, diarrhea, nausea, and dry mouth. Coleus may cause diarrhea and gastrointestinal upset.
Does this have caffeine or stimulants?
The product is labeled 'Stim Free,' meaning it does not contain caffeine or traditional stimulants. However, Ashwagandha and Huperzine A are pharmacologically active compounds that affect brain and body chemistry, so the term 'stim free' refers to the absence of caffeine-type stimulants, not overall activity.
Will this help with weight loss or metabolism?
The product contains a 'Targeted Fat Melting Matrix' and AfraLean, but we hold no effectiveness data for these ingredients to support weight loss claims. Talk with your doctor about whether this product is appropriate for your goals.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enduralean Stim Free Pink Lemonade is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enduralean Stim Free Pink Lemonade label
Sources

Sources & How We Checked

Enduralean Stim Free Pink Lemonade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 93 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
  17. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
  18. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
  19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
  20. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
  21. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
  22. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
  23. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  24. Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
  25. Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
  26. Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
  27. Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
  28. Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
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Terminalia 9 references
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Grains Of Paradise 2 references
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Huperzine A 13 references
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Coleus 16 references
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Goldthread 3 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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