Major interaction on record — check this product against your medications before combining. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Essential Amino Complete Strawberry Kiwi Ingredients & Drug Interactions

by GNC Pro Performance

Powder Category: Other Combinations
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Essential Amino Complete Strawberry Kiwi is a dietary supplement by GNC Pro Performance with 9 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 273 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B6, Sodium Chloride, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Essential Amino Complete Strawberry Kiwi by GNC Pro Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 7 of its 16 active ingredients.
  • “Branched-Chain Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Essential Amino Acid Blend” is a proprietary blend — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Electrolyte Complex” is a proprietary blend — the label gives one combined amount (1.11 Gram(s)) without saying how much of each component you get.

This powder contains 16 active ingredients: the amino acid building blocks L-leucine, L-isoleucine, L-valine, histidine, threonine, lysine, phenylalanine, tryptophan, and methionine, along with vitamin B6, and the minerals potassium and sodium (supplied as potassium chloride, sodium chloride, and other electrolyte forms). These amino acids are the protein components your body uses for muscle repair and recovery; the B vitamin and electrolytes support energy and fluid balance.

The product also contains inactive ingredients (fillers and flavorings) including citric acid, malic acid, natural and artificial flavors, sucralose, acesulfame potassium, and FD&C Red #40.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support muscle recovery and protein synthesis.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle protein synthesis, Lean muscle mass, Post-exercise recovery.
  • The closest evidence on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for this product's active ingredients is mixed. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and likely effective for high homocysteine; it's possibly effective for pregnancy-related nausea.

Lysine is possibly effective for cold sores. Histidine, threonine, phenylalanine, methionine, and tryptophan lack established evidence for the general athletic or recovery uses this product markets, though some show insufficient or mixed evidence in specific disease states.

Because this is a complete amino acid blend meant for muscle support, the effectiveness relies on your body's need for these building blocks—not on proven clinical effects for a particular condition. If you're looking to use it for a specific health goal, check with your doctor or pharmacist.

The evidence, ingredient by ingredient Vitamin B6 Potassium Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily; high doses over time can harm nerves (sensory neuropathy), though this is rare at lower intakes. Potassium and sodium are generally well tolerated in normal amounts but can cause serious problems—dangerously high blood levels (hyperkalemia from potassium, hypernatremia from sodium)—especially in people with kidney disease.

Lysine, phenylalanine, threonine, histidine, and methionine are generally well tolerated in food amounts; supplement safety at higher doses is not well studied. Common mild side effects from these ingredients include abdominal pain, nausea, diarrhea, headache, and heartburn.

If you have kidney disease, heart disease, or take diuretics or blood pressure medications, talk with your doctor or pharmacist before using this product, as the potassium and sodium content matters.

Side effects, ingredient by ingredient Vitamin B6 Potassium Sodium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lysine, Phenylalanine, Potassium, Vitamin B6, Threonine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 273 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take NMDA antagonists (psychiatric or neurological drugs); levodopa (Parkinson's); baclofen (muscle relaxant); MAOIs (older antidepressants); blood pressure drugs (ACE inhibitors, ARBs, or antihypertensive drugs); heart rhythm drugs like amiodarone; seizure drugs (phenobarbital, phenytoin); potassium-sparing diuretics; corticosteroids; lithium; or 5-HT4 agonists. No interactions are documented for L-leucine, L-isoleucine, L-valine, tryptophan, or chloride, as we could not check them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is an amino acid and electrolyte powder designed for muscle recovery. It's generally well tolerated if you're healthy and don't take medications that interact with its potassium, sodium, or other active ingredients.

If you take any prescription medications—especially for blood pressure, heart rhythm, seizures, Parkinson's disease, mood, or muscle tone—check your medications against the interactions listed on this page before starting. Talk it over with your own doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Essential Amino Complete Strawberry Kiwi, straight from the product label.

Brand GNC Pro Performance
Barcode (UPC) 048107189280
Net contents 15.87 Oz(s); 450 Gram(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221014
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Essential Amino Complete Strawberry Kiwi by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 Gram(s)
Maximum serving Sizes:
15 Gram(s)
Servings per container
30
UPC/BARCODE
048107189280
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Vitamin B60.64 mg38%
L-Leucine2.5 Gram(s)--
Potassium Chloride0 NP--
L-Isoleucine1.25 Gram(s)--
L-Valine1.25 Gram(s)--
Sodium Chloride0 NP--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Potassium210 mg4%
Branched-Chain Amino Acids5 Gram(s)--
Trisodium Citrate Dihydrate0 NP--
Essential Amino Acid Blend5 Gram(s)--
Histidine, Micronized0 NP--
Electrolyte Complex1.11 Gram(s)--
Chloride760 mg33%
Sodium215 mg9%
Total Essential Amino Acids10 Gram(s)--
Threonine, Micronized0 NP--
Lysine, Micronized0 NP--
Phenylalanine, Micronized0 NP--
Tryptophan, Micronized0 NP--
Methionine, Micronized0 NP--

Other ingredients: Citric Acid, Malic Acid, Natural and Artificial flavors, Sucralose, Acesulfame Potassium, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Pro Performance Essential Amino Complete Results Essential amino acids (EAA), including branched chain amino acids (BCAA), cannot be made by the body and therefore must be obtained through your diet. These amino acids are crucial to lean muscle maintenance and for helping to reduce muscle protein breakdown. Essential Amino Complete contains 5 grams of BCAA in an optimal 2:1:1 ratio to support protein synthesis, plus an additional 5 grams of EAA for muscle recovery and electrolytes for hydration. When used in conjunction with an exercise program.

Quality Essential Amino Complete is tested and certified Banned Substance Free. It tastes amazing, contains no sugar and mixes easily with a simple stir, shake or blend.

Usage Benefits During Workout Hydrates and fuels muscles. Post-Workout Supports recovery. Non-Training Days May be used to support muscle protein synthesis and help reduce muscle protein breakdown.

Fuels muscles Supports recovery Replenishes electrolytes

Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

Seals/Symbols

Banned Substance Free

Informedchoice.org Trusted by sport

Formula

10 G Total Aminos 5 G BCAA 5 G EAA

Natural and artificial flavors

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, mix one scoop in 10-16 fl. oz. of cold water and consume during workouts, post-workout and/or throughout the day. See usage benefits.

General Statements

Notice: Significant product settling may occur.

Products bearing this logo have been tested for banned substances by LGC Science, Inc., a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2018 World Anti-Doping Agency (WADA) Prohibited List via LGC skip lot testing protocol #ICP0307. See gnc.com for more information.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Essential Amino Complete Strawberry Kiwi by GNC Pro Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Essential Amino Complete Strawberry Kiwi by GNC Pro Performance

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size15 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
0.64 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Potassium

Interacts with
62 drugs
210 mg per serving Form: Potassium Chloride

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Electrolyte Complex

1.11 Gram(s) per serving

Chloride

760 mg per serving Form: Potassium Chloride, Sodium Chloride

Sodium

Interacts with
205 drugs
215 mg per serving Form: Sodium Chloride, Trisodium Citrate Dihydrate

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Total Essential Amino Acids

10 Gram(s) per serving
  • › Branched-Chain Amino Acids
  • › Essential Amino Acid Blend

Other (inactive) ingredients: Citric Acid, Malic Acid, Natural and Artificial flavors, Sucralose, Acesulfame Potassium, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Essential Amino Complete Strawberry Kiwi by GNC Pro Performance Drug Interactions

Want to check YOUR meds against Essential Amino Complete Strawberry Kiwi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
273Drugs
8 Major 264 Moderate 1 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Essential Amino Complete Strawberry Kiwi with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D

Sodium Chloride7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
The maker

Brand information

Manufacturer and brand details for Essential Amino Complete Strawberry Kiwi, from the product label.

GNC Pro Performance

See all GNC Pro Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Essential Amino Complete Strawberry Kiwi by GNC Pro Performance: Common Questions

Does Essential Amino Complete Strawberry Kiwi by GNC Pro Performance interact with any medications?
Yes. Based on its ingredients, Essential Amino Complete Strawberry Kiwi has a known interaction with 273 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Essential Amino Complete Strawberry Kiwi contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Pregnancy and breastfeeding safety varies by ingredient. Vitamin B6 is likely safe in pregnancy (though some data suggest caution); phenylalanine should be avoided in supplement form during pregnancy and breastfeeding. For lysine, threonine, histidine, and methionine, there isn't enough reliable data to say. Talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding.
What are the amino acids in this powder for?
Amino acids are the building blocks of protein. Your body uses them to build and repair muscles, enzymes, and other tissues. This blend supplies the nine essential amino acids your body can't make on its own, plus electrolytes (potassium and sodium) to support hydration and muscle function.
Can this product cause nerve damage?
Vitamin B6 at very high doses over time can cause sensory nerve damage (neuropathy), but this powder's dose is not specified on the label. At doses under 100 mg daily, it's well tolerated. The other amino acids are generally safe in typical supplement amounts, though their long-term safety at high doses isn't well studied.
Is this okay for people with kidney disease?
This product contains potassium and sodium, which can build to dangerous levels in people with kidney disease. If you have kidney disease or reduced kidney function, talk with your doctor or pharmacist before using this product.
What are the most common side effects?
The amino acids and B vitamin in this product can cause abdominal pain, nausea, diarrhea, headache, and heartburn in some people. These are usually mild, but if they persist or worsen, stop use and talk with your pharmacist.
Does this product have any fillers?
Yes. Besides the active amino acids, B vitamin, and electrolytes, it contains inactive ingredients: citric acid, malic acid, natural and artificial flavors, sucralose, acesulfame potassium, and FD&C Red #40.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Essential Amino Complete Strawberry Kiwi is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Essential Amino Complete Strawberry Kiwi label
Sources

Sources & How We Checked

Essential Amino Complete Strawberry Kiwi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 131 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
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Sodium 38 references
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Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
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  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

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Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
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  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
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  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

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Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
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  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

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Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
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  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
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  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
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  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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