Even + CBD Isolate Unflavored Ingredients & Drug Interactions
by zolt.
What is this page for?
First and foremost: checking Even + CBD Isolate Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Even + CBD Isolate Unflavored is a dietary supplement by zolt. with 2 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,100 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Hemp Cannabidiol Extract Isolate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Even + CBD Isolate Unflavored by zolt.
Ask about any prescription or over-the-counter medication and we check it for interactions with Even + CBD Isolate Unflavored by zolt. — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Even + CBD Isolate Unflavored by zolt.
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: hemp cannabidiol extract isolate, a concentrated form of compounds from hemp. The inactive ingredient is Nutriose, a type of fiber used as a filler in the powder.
Does it work?
Not established
The evidence we hold doesn't establish effectiveness for any condition. Hemp cannabidiol isolate has insufficient reliable evidence to rate for constipation, eczema (atopic dermatitis), and familial hypercholesterolemia—meaning studies are too limited or unclear to say whether it works for these purposes.
How safe is it?
Well-documented data
Hemp seed foods are generally well tolerated, but concentrated extracts and supplements like this one are less studied, so caution is advised. In larger amounts, hemp seed oil appears to be well tolerated overall.
Serious side effects are rare but have been reported: anaphylaxis (severe allergic reaction), long QT syndrome (a heart rhythm problem), and syncope (fainting). Allergies to hemp seed are uncommon but do occur—reactions have included hives, facial swelling, shortness of breath, and in one case anaphylaxis.
There's also a rare case report of elevated liver enzymes and hepatitis in a young child given a very high dose of hemp extract for seizures.
Meds to double-check
Moderate interaction found
Check this product with your pharmacist before taking it if you're on estrogens or hormone therapy (moderate interaction risk), blood pressure medications or ACE inhibitors (minor risk of blood pressure dropping further), blood thinners (minor risk of increased bleeding), or any drugs processed by the liver—hemp may reduce their effectiveness.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This is a single-ingredient hemp CBD isolate powder with no proven effectiveness for the conditions we have data on. If you're on hormone therapy, blood pressure medications, blood thinners, or drugs metabolized by your liver, run this product through the medication checker before starting.
Talk with your pharmacist if you have a history of allergies to hemp or other plants.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Even + CBD Isolate Unflavored, straight from the product label.
| Brand | zolt. |
|---|---|
| Barcode (UPC) | 850009849076 |
| Net contents | 10 Mixie Stick(s); 1.4 Ounce(s); 40 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 296882 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Even + CBD Isolate Unflavored by zolt., sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 4 Gram(s) | 2% |
| Dietary Fiber | 3 Gram(s) | 12% |
| Hemp Cannabidiol Extract Isolate | 200 mg | -- |
Other ingredients: Nutriose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
CBD Isolate 20MG Plant Botanicals
Supports calm & Stability CBD Isolate
Formulated with US-farmed hemp
Kosher, plant-based, and gluten-free
Formulation
THC-Free
Balance Plant-Powered SuperDrink Mix for Mood, Mind, and Body Even your everyday equilibrium Balanced Calm Attention & Memory Anti-Inflammation
Caffeine-Free
Superdrink Blend This Zolt formulation uses bioactive plant botanicals to help you be at your best-mentally, physically, and emotionally. Made with love in the US Maximal Bioavailability Hyper-effective powder format Certificate of Analysis Batch-specific CoA available at heyzolt.com
Kosher, plant-based, and gluten-free
Kosher, plant-based, and gluten-free Third-party lab-tested Manufactured with care in the US in SQF, cGMP, and FDA certified facilities.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use Add contents of mixie stick to a bottle of water (16oz), shaking thoroughly to disperse adaptogens. Enjoy over ice, in a smoothie, or as a hot beverage.
Precautions
Product intended for adult use only.
Consult with your physician before use. Enjoy up to 8 mixie sticks per day.
Storage
Store at room temperature.
General Statements
Scan for CoA Come say hey heyzolt.com | @heyzolt
10-0.14 oz (4g) packets
1% donated to National Young Farmers Coalition
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Even + CBD Isolate Unflavored by zolt. label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Even + CBD Isolate Unflavored by zolt.
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Gram(s) Dosage formPowder Servings per container10 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsHemp Cannabidiol Extract Isolate
Interacts with938 drugs
Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...
Hemp Cannabidiol Extract Isolate monograph & interactionsOther (inactive) ingredients: Nutriose. These complete the product’s ingredient list but are not active constituents.
Even + CBD Isolate Unflavored by zolt. Drug Interactions
HelloPharmacist Interaction Report
Even + CBD Isolate Unflavored by zolt. contains hemp cannabidiol extract isolate, which has documented interactions with several medication types.
The most serious is a moderate interaction with estrogens (hormone therapy): hemp may interfere with how your body processes estrogens through its own estrogenic effects, potentially reducing the therapy's effectiveness. This was observed in animal studies showing hemp seed normalized estrogen levels, though the exact mechanism isn't fully clear.
Read the full breakdown — every affected drug type, severity by severity
Minor interactions are documented with blood pressure medications (antihypertensive drugs and ACE inhibitors), where hemp theoretically could add to their effects and lower blood pressure further. There's also a minor interaction with blood thinners (anticoagulant/antiplatelet drugs)—hemp seed may theoretically increase bleeding risk, though human studies of hemp seed oil haven't shown this effect.
Additionally, hemp may induce two liver enzymes (CYP1A2 and CYP3A4) that break down many medications, theoretically decreasing their levels and effects.
Altogether, these interactions span 939 individual medications. Because hemp's effects in concentrated supplement form are less studied than in food amounts, it's especially important to check your exact medications with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Even + CBD Isolate Unflavored?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Even + CBD Isolate Unflavored interact with 2,100 drugs. Click any drug to see the details.
2 of the 2 ingredients in Even + CBD Isolate Unflavored interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Hemp Cannabidiol Extract Isolate
Ethinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Desogestrel interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Drospirenone interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Ethynodiol Diacetate interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Levonorgestrel interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Norethindrone interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Norgestimate interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Norgestrel interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Ethinyl Estradiol, Levonogestrel interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ethinyl Estradiol, Levonogestrel interactionEtonogestrel, Ethinyl EstradiolNuvaRing
How Etonogestrel, Ethinyl Estradiol interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Etonogestrel, Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Etonogestrel, Ethinyl Estradiol interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Glipizide, Metformin interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glyburide, Metformin interactionLevonorgestrel, Ethinyl EstradiolLogynon ED, Microgynon 30, Nordette, Ovranette, Quartette, Trinordiol +1 more
How Levonorgestrel, Ethinyl Estradiol interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Levonorgestrel, Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Levonorgestrel, Ethinyl Estradiol interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Linagliptin, Metformin Hydrochloride interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Lithium Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Lithium Carbonate (prescription Drug) interactionMedroxyprogesterone Acetate, Oestrogens, ConjugatedPremique
How Medroxyprogesterone Acetate, Oestrogens, Conjugated interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Medroxyprogesterone Acetate, Oestrogens, Conjugated interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Medroxyprogesterone Acetate, Oestrogens, Conjugated interactionMetforminGlucophage, Metformin
How Metformin interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin Hydrochloride interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin, Sitagliptin interactionNorelgestromin, Ethinyl EstradiolEvra, Ortho Evra
How Norelgestromin, Ethinyl Estradiol interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Norelgestromin, Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Norelgestromin, Ethinyl Estradiol interactionNorethindrone Acetate, Ethinyl Estradiol, Ferrous FumarateLoMinastrin FE, Minastrin 24 FE
How Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate interactionOestrogenOestrogen
How Oestrogen interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Oestrogen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Oestrogen interactionOlanzapineZyprexa
How Olanzapine interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Olanzapine (zyprexa) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Olanzapine interactionHemp Cannabidiol Extract IsolateCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Olanzapine interactionPrasterone (prescription Drug)Intrarosa
How Prasterone (prescription Drug) interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Cannabidiol Extract Isolate + Prasterone (prescription Drug) interactionRelugolix, Estradiol, Norethindrone AcetateMyfembree
How Relugolix, Estradiol, Norethindrone Acetate interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Cannabidiol Extract Isolate + Relugolix, Estradiol, Norethindrone Acetate interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Relugolix, Estradiol, Norethindrone Acetate interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Even + CBD Isolate Unflavored — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Saxagliptin, Metformin Xr interactionSegesterone Acetate, Ethinyl EstradiolAnnovera
How Segesterone Acetate, Ethinyl Estradiol interacts with Even + CBD Isolate Unflavored — through 2 ingredients. Tap an ingredient for the detail:
Hemp Cannabidiol Extract IsolateEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Cannabidiol Extract Isolate + Segesterone Acetate, Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Segesterone Acetate, Ethinyl Estradiol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Even + CBD Isolate Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Hemp Cannabidiol Extract Isolate
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for Even + CBD Isolate Unflavored, from the product label.
zolt.
See all zolt. products- Name
- Cuboid, LLC
- Street Address
- PO Box 708
- City
- Short Hills
- State
- NJ
- ZipCode
- 07078
Even + CBD Isolate Unflavored by zolt.: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Even + CBD Isolate Unflavored is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Even + CBD Isolate Unflavored’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographHemp
Interacts with 938 drugsHemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...
Read the full Hemp monograph →Sources & How We Checked
Even + CBD Isolate Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Hemp 12 references
- Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
- Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
- Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
- Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
- Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
- Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
- Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
- Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
- Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
- Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
- Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC