Major interaction on record — check this product against your medications before combining. Based on 10 of 16 ingredients. Check your meds →
Dietary supplement

Fire Tonify Support The Heart Ingredients & Drug Interactions

by 5 Chinese Elements

Fire Tonify Support The Heart label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fire Tonify Support The Heart against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Fire Tonify Support The Heart is a dietary supplement by 5 Chinese Elements with 16 active ingredients. Its ingredients are commonly taken for immune support, colds and flu, upper respiratory infections.Based on those ingredients, 1,503 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Acorus, Chaparral, Rehmannia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fire Tonify Support The Heart by 5 Chinese Elements

Ask about any prescription or over-the-counter medication and we check it for interactions with Fire Tonify Support The Heart by 5 Chinese Elements — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Fire Tonify Support The Heart by 5 Chinese Elements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 16 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

Fire Tonify Support The Heart contains 16 ingredients, 10 of which we have data for. The active ingredients include astragalus (traditionally used to support immune function), yellow dock (a laxative herb), yucca, rehmannia, cuscuta (dodder), biota (oriental arborvitae), acorus (calamus), lotus, and chaparral.

A proprietary blend lists additional components. The remaining ingredients — Polygala, Ginseng, Ophiopogon, Succinum, Cistanche, and Ziziphus — are also active components.

There are no inactive fillers or binders listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: heart and circulation support.
  • We looked for evidence on: Angina, Heart failure, Myocardial infarction (MI), Myocarditis, Stroke, Hypercholesterolemia — and 4 related terms.
  • The closest evidence on file: Yucca is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Yucca is rated "Insufficient Reliable Evidence To Rate" for Hypertension.
  • Also on file: Calamus is rated "Insufficient Reliable Evidence To Rate" for Stroke.

The evidence for this product's ingredients is limited. Rehmannia is possibly effective for chronic kidney disease; the rest have insufficient reliable evidence to support their use.

Astragalus, yellow dock, yucca, cuscuta, acorus, biota, lotus, and chaparral show no established effectiveness in our data for the conditions they're traditionally used for.

The evidence, ingredient by ingredient Astragalus Yellow Dock Yucca Rehmannia Dodder American Ginseng Oriental Arborvitae Calamus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several ingredients in this product raise safety concerns. Chaparral is considered unsafe — it has been linked to serious liver and kidney damage, and the facts advise against its use.

Yellow dock may act as a laxative and contains oxalates; long-term use or raw forms can cause kidney stones and calcium loss. Acorus (calamus) is likely unsafe because it may increase cancer risk and contains potentially toxic compounds.

Astragalus is generally well tolerated short-term but has limited human safety data. Yucca, cuscuta, and biota have limited safety information in supplement form.

For pregnancy and breastfeeding, astragalus, yellow dock, yucca, cuscuta, acorus, biota, and chaparral all lack sufficient safety data and are advised against.

Side effects, ingredient by ingredient Astragalus Yellow Dock Yucca Rehmannia Dodder American Ginseng Oriental Arborvitae Calamus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 10 matched ingredients can interact with medications — Lotus, Yellow Dock, Calamus, Chaparral, Astragalus, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,504 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you use diuretics, digoxin (a heart drug), blood thinners like warfarin, blood pressure medications, diabetes drugs, sedatives, lithium, cancer therapy (cyclophosphamide), or any medication metabolized by your liver (CYP2D6 or CYP3A4 enzymes). Yellow dock and digoxin together carry the highest risk.

Acorus interacts with a broad range of liver-metabolized drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product has interactions with heart medications, blood thinners, blood pressure drugs, diabetes medications, and many others metabolized by the liver. Yellow dock and chaparral present particular safety concerns — chaparral is linked to liver damage, and yellow dock can cause electrolyte problems.

If you take any prescription medications or have liver or kidney issues, talk to your pharmacist or doctor before starting this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fire Tonify Support The Heart, straight from the product label.

Brand 5 Chinese Elements
Barcode (UPC) 635585075510
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22386
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fire Tonify Support The Heart by 5 Chinese Elements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
635585075510
IngredientAmount% DV
Astragalus0 NP--
Yellow Dock0 NP--
Yucca0 NP--
Rehmannia0 NP--
Polygala0 NP--
Cuscuta0 NP--
Ginseng0 NP--
Proprietary Blend1500 mg--
Ophiopogon0 NP--
Biota0 NP--
Acorus0 NP--
Polygonum0 NP--
Lotus0 NP--
Succinum0 NP--
Cistanche0 NP--
Chaparral0 NP--
Ziziphus0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#755 Heart - Circulation The Chinese 5 Element Formulas from Dragon Rising were created by A.S. "Doc" Wheelwright by using Eastern influences and modern research to develop the ultimate nutritional supplements for western culture. Qi: Heart 7 (Spirit Gate), Conception Vessel Support and strengthen the health of the heart and blood circulation.

MADE IN U.S.A.

SOLD THROUGH PROFESSIONALS

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR NUTRITIONAL USE: 1-3 capsules, up to four times per day for 1-4 months, or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

FDA Statement of Identity

Dietary Supplement

General

#755 E/11

Storage

KEEP OUT OF REACH OF HEAT, SUNLIGHT &CHILDREN.

Precautions

KEEP OUT OF REACH OF HEAT, SUNLIGHT &CHILDREN.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fire Tonify Support The Heart by 5 Chinese Elements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fire Tonify Support The Heart label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fire Tonify Support The Heart by 5 Chinese Elements

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1500 mg per serving
Interaction report

Fire Tonify Support The Heart by 5 Chinese Elements Drug Interactions

Want to check YOUR meds against Fire Tonify Support The Heart?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,503Drugs
78 Major 1,410 Moderate 15 Minor

Ingredients driving the most interactions

Acorus 1,117
Chaparral 370
Rehmannia 258
Ginseng 217
Lotus 212

Individual Drug Interactions

The ingredients in Fire Tonify Support The Heart interact with 1,503 drugs. Click any drug to see the details.

7 of the 16 ingredients in Fire Tonify Support The Heart interact with drugs. Each result below shows which ingredient is responsible. Acorus Chaparral Rehmannia Ginseng Lotus Astragalus Yellow Dock

Each ingredient & the kinds of drugs it affects

For each ingredient in Fire Tonify Support The Heart with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Acorus10 drug types · 1,117 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.
In vitro evidence shows that calamus can inhibit acetylcholinesterase (AChE).

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking calamus with other antihypertensive medications might increase the risk of hypotension.
Animal research shows that calamus decreases the rate and strength of the heartbeat, which might lower blood pressure. use with caution.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and calamus might have an additive effect and increase the risk of cholinergic effects.
In vitro evidence shows that calamus can inhibit acetylcholinesterase (AChE).

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.
Animal research shows that calamus is a CNS depressant and increases gamma-aminobutyric acid levels.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effects.
In vitro research shows that calamus extract inhibits CYP2D6 enzyme.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
In vitro research shows that calamus extract inhibits CYP3A4 enzyme.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, calamus might potentiate the effects and adverse effects of MAOIs.
Some reports suggest that calamus increases the effects of MAOIs.

Likelihood Possible Evidence D
Antacids

Theoretically, taking calamus might reduce the effectiveness of antacids.
Some research suggests that calamus lowers gastric pH.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, taking calamus might reduce the effectiveness of H2-blockers.
Some research suggests that calamus lowers gastric pH.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, taking calamus might reduce the effectiveness of PPIs.
Some research suggests that calamus lowers gastric pH.

Likelihood Possible Evidence D
Acorus full monograph & interactions

Chaparral1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Likelihood Possible Evidence D
Chaparral full monograph & interactions

Rehmannia2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia full monograph & interactions

Ginseng4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
Ginseng full monograph & interactions

Lotus3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.
Neferine and isoliensinine, constituents of lotus, have been shown to inhibit platelet aggregation, in vitro. These constituents can inhibit the production of pro-aggregating factors like prostaglandins.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Animal research shows that the ethanolic extract of lotus reduces blood glucose levels and potentiates the effects of injected insulin. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, taking lotus concomitantly with pentobarbital might increase sedation.
Animal research shows that lotus extract increases pentobarbitone-induced sleeping time. It is not known if this occurs in humans or if this effect occurs with other barbiturates or sedatives.

Likelihood Possible Evidence D
Lotus full monograph & interactions

Astragalus4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus full monograph & interactions

Yellow Dock3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Yellow Dock full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fire Tonify Support The Heart, from the product label.

5 Chinese Elements

See all 5 Chinese Elements products
Name
Dragon Rising, A division of Systemic Formulas Inc.
Street Address
P.O. Box 1516
City
Ogden
State
UT
ZipCode
84402
Web Address
www.systemicformulas.com
Pharmacist Counseling Corner

Fire Tonify Support The Heart by 5 Chinese Elements: Common Questions

Does Fire Tonify Support The Heart by 5 Chinese Elements interact with any medications?
Yes. Based on its ingredients, Fire Tonify Support The Heart has a known interaction with 1,503 medications, including 78 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fire Tonify Support The Heart contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take with my heart or blood pressure medication?
Not necessarily. Yellow dock in this product interacts with digoxin (a common heart medication) and can cause dangerous potassium loss, especially with diuretics. Rehmannia and acorus can lower blood pressure. Check your exact medications with the tool on this page or ask your pharmacist before you start.
Can I take this if I'm on a blood thinner like warfarin?
You should check first. Yellow dock in this product has a laxative effect that can increase warfarin's blood-thinning action and bleeding risk. Lotus may also interact with blood thinners. Talk to your pharmacist before combining them.
What are the side effects I should watch for?
Yellow dock may cause diarrhea or dermatitis with long-term use. Acorus can cause nausea and vomiting. Chaparral has been linked to liver damage — signs include jaundice, dark urine, and right-sided belly pain. Cuscuta at high doses may cause intestinal cramping and diarrhea. Stop and contact your doctor if you notice any of these.
Is this safe during pregnancy or while breastfeeding?
No. Astragalus, yellow dock, yucca, cuscuta, acorus, biota, and chaparral all lack sufficient safety data for pregnancy and lactation, and the facts advise against their use during these times. Talk with your doctor or midwife before considering any supplement.
Does this actually work for the heart?
The evidence in our data is limited. Rehmannia is possibly effective for chronic kidney disease, but effectiveness for heart support specifically is not established. The other ingredients have insufficient reliable evidence.
What's in the proprietary blend, and why isn't it itemized?
The proprietary blend contains additional active ingredients, but the manufacturer doesn't disclose the exact amounts or all components to protect their formula. The individual ingredients are listed separately so you can check each one for interactions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fire Tonify Support The Heart is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fire Tonify Support The Heart label
Go deeper

The Full Monographs Behind Fire Tonify Support The Heart’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Yellow Dock

Interacts with 78 drugs

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...

Read the full Yellow Dock monograph → Herb & supplement monograph

Yucca

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for t...

Read the full Yucca monograph → Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Dodder

Dodder (Cuscuta) is a parasitic plant whose seeds are used in traditional Chinese and Middle Eastern medicine, mainly for sexual, kidney, and energy-related complaints. Human evidence for an...

Read the full Dodder monograph → Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Oriental Arborvitae

Oriental Arborvitae is an evergreen conifer used in Traditional Chinese Medicine, where the seeds (Bai Zi Ren) are taken to calm the mind and ease constipation, and the leaves (Ce Bai Ye) ar...

Read the full Oriental Arborvitae monograph → Herb & supplement monograph

Calamus

Interacts with 1,117 drugs

Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complaints. However, it contains beta-asarone, a compound...

Read the full Calamus monograph → Herb & supplement monograph

Lotus

Interacts with 212 drugs

Lotus is an edible aquatic plant used in food and traditional medicine across Asia, with parts like the seeds, leaves, and flowers taken for digestion, calm, and overall wellness. Most healt...

Read the full Lotus monograph → Herb & supplement monograph

Chaparral

Interacts with 370 drugs

Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious and sometimes irreversible liver and kidn...

Read the full Chaparral monograph →
Sources

Sources & How We Checked

Fire Tonify Support The Heart's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 78 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astragalus 13 references
  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
  7. Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
  8. Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
  10. Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
  11. Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
  12. Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
  13. Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):

See these in context on the Astragalus monograph →

Yellow Dock 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
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Yucca 3 references
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Rehmannia 3 references
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Dodder 3 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Mehrbani M, Choopani R, Fekri A, Mehrabani M, Mosaddegh M, Mehrabani M. The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial. J Ethnopharm PubMed
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American Ginseng 12 references
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Oriental Arborvitae 2 references
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  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Oriental Arborvitae monograph →

Calamus 13 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publ, 1997.
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  8. Vargas, C. P., Wolf, L. R., Gamm, S. R., and Koontz, K. Getting to the root (Acorus calamus) of the problem. J Toxicol Clin Toxicol 1998;36(3):259-260.
  9. Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.
  10. Sharma V, Singh I, Chaudhary P. Acorus calamus (The Healing Plant): a review on its medicinal potential, micropropagation and conservation. Nat Prod Res. 2014;28(18):1454-66.
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  12. Federal Register. Volume 33, Page 6967. U.S. Government Publishing Office. http://api.fdsys.gov/link?collection=fr&volume=33&page=6967. Accessed May 23, 2018.
  13. Electronic Code of Federal Regulations. Title 21. Part 189 - Substances Prohibited From Use in Human Food. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=259fa8a1284cad42676075c8425c7333&mc=true&node=pt21.3.189&rgn=div5.

See these in context on the Calamus monograph →

Lotus 5 references
  1. Yu, J. and Hu, W. S. [Effects of neferine on platelet aggregation in rabbits]. Yao Xue.Xue.Bao. 1997;32(1):1-4.
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  4. Mukherjee, P. K., Saha, K., Pal, M., and Saha, B. P. Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol. 1997;58(3):207-213. PubMed
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Chaparral 16 references
  1. Smith BC, Desmond PV. Acute hepatitis induced by ingestion of the herbal medication chaparral. Aust N Z J Med 1993;23:526.. PubMed
  2. Gordon DW, Rosenthal G, Hart J, et al. Chaparral ingestion: the broadening spectrum of liver injury caused by herbal medications. JAMA 1995;273:489-90.
  3. Batchelor WB, Heathcote J, Wanless IR. Chaparral-induced hepatic injury. Am J Gastroenterol 1995;90:831-3.
  4. Katz M, Saibil F. Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6.
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  8. Chaparral-induced toxic hepatitis-California and Texas, 1992. MMWR Morb Mortal Wkly Rep 1992;41:812-4.. DOI
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  13. Kauma, H., Koskela, R., Makisalo, H., Autio-Harmainen, H., Lehtola, J., and Hockerstedt, K. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand.J Gastroenterol. 2004;39(11):1168-1171. PubMed
  14. Leonforte, J. F. Contact dermatitis from Larrea (creosote bush). J Am Acad.Dermatol. 1986;14(2 Pt 1):202-207. PubMed
  15. Alderman, S., Kailas, S., Goldfarb, S., Singaram, C., and Malone, D. G. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin.Gastroenterol. 1994;19(3):242-247.
  16. Clark, F. Chaparral-induced toxic hepatitis: California and Texas, 1992. MMWR Morb Mortal Wkly Rep. 1992;41:812-814. DOI

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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