Flax Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Flax against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Flax is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for constipation and digestive health, high cholesterol, heart health.Based on those ingredients, 597 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flaxseed Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Flax by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Flax by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Flax by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 1 active ingredient: flaxseed extract, dry. Flaxseed is rich in lignans and alpha-linolenic acid (ALA), plant compounds that researchers have studied for effects on cholesterol, blood sugar, blood pressure, and hormone-related symptoms.
The liquid form also contains alcohol, water, and glycerin as inactive ingredients to preserve and deliver the extract.
Does it work?
Moderate evidence
The evidence we hold shows flaxseed extract is possibly effective for high cholesterol, high blood pressure, diabetes, and constipation. It's also rated possibly effective for mastalgia (breast tenderness).
Keep in mind that 'possibly effective' means the research is suggestive but not yet definitive — more study is needed to confirm how well it works for any of these uses.
How safe is it?
Well-documented data
Flaxseed is generally well tolerated when used as a food, but digestive side effects are common, especially at higher doses. Most people experience bloating, gas, diarrhea, or other gastrointestinal complaints — and doses over 45 grams per day may not be tolerable because of diarrhea risk.
Start with small amounts and drink plenty of water. Severe allergic reactions, including anaphylaxis, are rare but possible.
At supplement doses, flaxseed can have hormone-like effects, so the safety data advises against use unless your doctor approves. There isn't enough reliable information about safety during breastfeeding at supplement doses, so talk with your doctor or pharmacist before using it if you're nursing.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you're on blood thinners (anticoagulants or antiplatelet drugs), blood pressure medications, antibiotics, birth control or hormone therapy, or diabetes drugs — all have documented Moderate interactions with flaxseed.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Flaxseed extract may help with cholesterol, blood pressure, blood sugar, or constipation if the research pans out for your situation, but it's not a substitute for prescription medication. Because it interacts with blood thinners, blood pressure drugs, antibiotics, hormonal contraceptives, and diabetes medications, you'll want to check your exact prescriptions before starting — talk it over with your doctor or pharmacist to make sure it's safe alongside what you're already taking.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Flax, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253622037 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 301587 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Flax by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Flaxseed Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Formula
Linum usitatissimum
Organic Alcohol Based
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
Made in USA, Hawaii
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Flax by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Flax by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Flaxseed Extract, Dry
Interacts with597 drugs
Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and...
Flaxseed Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Flax by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Hawaii Pharm Flax is a single-ingredient liquid extract that does interact with medications.
Through its flaxseed content, it can affect blood pressure drugs, antibiotics, hormone medications, blood thinners, and diabetes drugs — all at Moderate severity. The most serious concern is with blood thinners (anticoagulants and antiplatelet drugs): flaxseed's oil may reduce how easily your blood clots, and combining it with these medications could raise your bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
Flaxseed may also lower your blood pressure, especially if you take it daily for more than 12 weeks, so it can add to the effect of blood pressure medications and increase the risk of excessively low blood pressure (hypotension). It may interfere with how antibiotics are processed in your body and could theoretically reduce how well estrogen-containing medications (like birth control or hormone therapy) work.
And because some research suggests flaxseed can lower blood sugar, pairing it with diabetes drugs might push your levels too low (hypoglycemia).
Altogether, these interactions span 597 individual medications. Before you start this product, run your exact prescriptions through the checker below.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Flax?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Flax interact with 597 drugs. Click any drug to see the details.
1 of the 1 ingredient in Flax interact with drugs. Each result below shows which ingredient is responsible. Flaxseed Extract, Dry
AbciximabReoPro
How Abciximab interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed Extract, Dry + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed Extract, Dry + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed Extract, Dry + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed Extract, Dry + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed Extract, Dry + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flaxseed Extract, Dry + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flaxseed Extract, Dry + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Ambrisentan interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flaxseed Extract, Dry + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Flax — through 1 ingredient. Tap an ingredient for the detail:
Flaxseed Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed Extract, Dry + Ammonium Chloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Flax with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Flaxseed Extract, Dry
Antibiotic Drugs
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.
Anticoagulant/Antiplatelet Drugs
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.
Antidiabetes Drugs
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.
Estrogens
Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.
Brand information
Manufacturer and brand details for Flax, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
Flax by Hawaii Pharm: Common Questions
Does Flax by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will flaxseed help my high cholesterol?
What are the most common side effects?
Is it safe to take while pregnant?
Can I take this if I'm breastfeeding?
Does flaxseed actually lower blood pressure?
What does 'dry extract' mean?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Flax is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Flax’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Flax's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Flaxseed 37 references
- Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
- Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
- Thompson LU, Rickard SE, Cheung F, et al. Variability in anticancer lignan levels in flaxseed. Nutr Cancer 1997;27:26-30. PubMed
- Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
- Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
- Clark WF, Parbtani A, Huff MW, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475-80. PubMed
- Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. PubMed
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
- Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
- Clark WF, Kortas C, Heidenheim P, et al. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr 2001;20:143-8. PubMed
- Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991;60:135-42. PubMed
- Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 2000;161:47-55. PubMed
- Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
- Adlercreutz H, Fotsis T, Bannwart C, et al. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 1986;25:791-7.. PubMed
- Rose DP. Dietary fiber and breast cancer. Nutr Cancer 1990;13:1-8.. PubMed
- Lemay A, Dodin S, Kadri N, et al. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 2002;100:495-504.. DOI
- Brooks JD, Ward WE, Lewis JE, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr 2004;79:318-25.. PubMed
- Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
- Dodin S, Lemay A, Jacques H, et al. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 2005 PubMed
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
- Demark-Wahnefried W, Polascik TJ, George SL, et al. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 2008;17:3577-87. PubMed
- Thompson LU, Chen JM, Li T, et al. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res 2005;11:3828-35. PubMed
- Mani UV, Mani I, Biswas M, Kumar SN. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl 2011;8:257-65.
- Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J 2011;10:44. PubMed
- Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metab 2009;34:89-98. PubMed
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