Gluco-Control Plus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Gluco-Control Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Gluco-Control Plus is a dietary supplement by AN American Nutriceuticals with 3 active ingredients. Its ingredients are commonly taken for blood sugar and diabetes support, athletic performance and muscle building, lowering cholesterol.Based on those ingredients, 241 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vanadyl Sulfate, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Gluco-Control Plus by AN American Nutriceuticals
Ask about any prescription or over-the-counter medication and we check it for interactions with Gluco-Control Plus by AN American Nutriceuticals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Gluco-Control Plus by AN American Nutriceuticals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Gluco-Control Plus contains 3 active ingredients: vanadyl sulfate (a form of vanadium), chromium, and a proprietary Synergistic Gluco Herbal Blend. The product also includes two inactive ingredients — magnesium citrate and vegetable cellulose — that serve as the capsule and binding materials.
Vanadium and chromium are both minerals that play a role in how your body handles blood sugar and may improve how cells respond to insulin. The herbal blend's composition is not detailed in the facts we hold.
Does it work?
Strong evidence
Vanadium appears likely effective for treating vanadium deficiency, but for diabetes specifically, the evidence we hold is insufficient to rate its effectiveness. Chromium shows possibly effective results for managing diabetes, though it did not perform better than placebo for prediabetes.
The evidence for the Synergistic Gluco Herbal Blend is not on file. If you're taking this product hoping to manage blood sugar, talk with your doctor or pharmacist about what the clinical evidence supports for your situation.
How safe is it?
Well-documented data
Vanadium is well tolerated at small dietary amounts, but supplement doses — especially above 1.8 mg daily — can cause stomach upset, diarrhea, nausea, and abdominal discomfort. Long-term use at high doses has rarely caused kidney damage.
Chromium is generally well tolerated at typical supplement levels, though high or prolonged doses may carry risks; reported side effects include headaches, insomnia, mood changes, skin rashes, and in rare cases, kidney or liver damage. Allergic reactions to vanadium have been documented in people exposed to vanadium metal or vanadium-containing devices.
For pregnancy: vanadium safety data advises against supplement doses during pregnancy, though the data show conflicting ratings (likely safe and possibly unsafe); talk with your doctor before taking this product if you are pregnant or planning to become pregnant. For breastfeeding, vanadium safety is unknown and should be avoided unless your doctor advises otherwise.
Chromium is generally considered acceptable in small amounts from food or prenatal vitamins, but extra supplement doses should not be taken unless your doctor recommends it.
Meds to double-check
Moderate interaction found
Before taking Gluco-Control Plus, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, clopidogrel, aspirin) — vanadium may increase bleeding risk. Also confirm your use of diabetes medications, insulin, levothyroxine (Synthroid), NSAIDs, or aspirin, since all interact Moderately or Minor with the product's ingredients and may have their effect changed or reduced.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Gluco-Control Plus is aimed at people managing blood sugar, but the evidence for its main ingredients in diabetes is limited or mixed. The biggest cautions are for anyone taking blood thinners, diabetes medications, insulin, or levothyroxine — all of which can interact with vanadium or chromium in ways that change their effect or safety.
If you take any prescription medication or are pregnant or breastfeeding, talk with your doctor or pharmacist before starting this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Gluco-Control Plus, straight from the product label.
| Brand | AN American Nutriceuticals |
|---|---|
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 25, 2012 |
| DSLD ID | 14250 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Gluco-Control Plus by AN American Nutriceuticals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vanadyl Sulfate | 4 mg | -- |
| Chromium | 51 mcg | 42% |
| Synergistic Gluco Herbal Blend | 540 mg | -- |
Other ingredients: Magnesium Citrate, Vegetable Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Gluco-Control Plus contains a synergistic blend of herbs and minerals traditionally used and researched to help maintain and control healthy blood sugar levels that are in the normal range.
PROFESSIONAL SERIES CLINICAL STRENGTH
Natural Glucose Support
Precautions
Warnings: This product may reduce blood sugar levels. Consult your Health Care Provider if you are hypoglycemic or diabetic.
Keep out of reach if children.
Contact your Health Care Provider if you are taking any medications. Do not use if pregnant or nursing.
Seals/Symbols
(recycle) Please recycle
(no) BPA
AN
General
Item #A1017 LGC1
Suggested/Recommended/Usage/Directions
Suggested Use: 1-2 capsules per day, between meals or as directed by your Health Care Professional.
Formulation
Vegetarian & Vegan.
Gluten, dairy & soy free.
Storage
Store in a cool,dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Gluco-Control Plus by AN American Nutriceuticals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Gluco-Control Plus by AN American Nutriceuticals
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vanadyl Sulfate
Interacts with208 drugs
Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athle...
Vanadyl Sulfate monograph & interactionsChromium
Interacts with178 drugs
Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...
Chromium monograph & interactionsSynergistic Gluco Herbal Blend
Other (inactive) ingredients: Magnesium Citrate, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.
Gluco-Control Plus by AN American Nutriceuticals Drug Interactions
HelloPharmacist Interaction Report
Gluco-Control Plus by American Nutriceuticals carries documented interactions through its vanadyl sulfate and chromium content.
The most serious concern is a Moderate-severity risk of bleeding (hemorrhage) when combined with blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel — vanadium may prolong clotting time and raise bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
Both vanadyl sulfate and chromium can lower blood sugar (hypoglycemia) when taken alongside diabetes medications or insulin, a Moderate-severity interaction. Chromium also reduces how well your body absorbs levothyroxine (Synthroid and generics), a thyroid replacement drug, cutting its levels by up to 17% in clinical testing — another Moderate-severity effect.
Additionally, NSAIDs and aspirin may increase how much chromium your body absorbs and retains, ranked Minor in severity.
We could not check the third ingredient, Synergistic Gluco Herbal Blend, because we hold no monograph data for it. Altogether, these interactions span 241 individual medications.
Use the medication checker on this page to look up your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Gluco-Control Plus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Gluco-Control Plus interact with 241 drugs. Click any drug to see the details.
2 of the 3 ingredients in Gluco-Control Plus interact with drugs. Each result below shows which ingredient is responsible. Vanadyl Sulfate Chromium
AbciximabReoPro
How Abciximab interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Acarbose interactionChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Acetaminophen, Aspirin interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Acetaminophen, Aspirin, Caffeine interactionChromiumAspirin, Nonsteroidal Anti-inflammatory Drugs (nsaids) Minor
Interaction Summary
Theoretically, aspirin might increase chromium absorption.
Read the full Chromium + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Acetaminophen, Ibuprofen interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids) Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Acetohexamide interactionVanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Acetylsalicylic Acid interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Albiglutide interactionVanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Alogliptin interactionChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Alogliptin, Metformin interactionVanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Alogliptin, Pioglitazone interactionChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vanadyl Sulfate + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Gluco-Control Plus — through 1 ingredient. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin, Butalbital interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin, Butalbital, Caffeine interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin, Butalbital, Caffeine, Phenacetin interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Gluco-Control Plus — through 2 ingredients. Tap an ingredient for the detail:
Vanadyl SulfateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Vanadyl Sulfate + Aspirin, Caffeine interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Gluco-Control Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Vanadyl Sulfate
Anticoagulant/Antiplatelet Drugs
Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.
Antidiabetes Drugs
Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.
Chromium
Antidiabetes Drugs
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.
Insulin
Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,
Levothyroxine (Synthroid, Others)
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.
Aspirin
Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.
Brand information
Manufacturer and brand details for Gluco-Control Plus, from the product label.
AN American Nutriceuticals
See all AN American Nutriceuticals products- Name
- American NUTRICEUTICALS(TM)
- Phone Number
- 888-848-2548
- Web Address
- www.888vitality.com
Gluco-Control Plus by AN American Nutriceuticals: Common Questions
Does Gluco-Control Plus by AN American Nutriceuticals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Gluco-Control Plus if I'm on levothyroxine for my thyroid?
Will this lower my blood sugar too much if I'm already on diabetes medication?
Is vanadium safe long-term?
What's in the Synergistic Gluco Herbal Blend, and does it interact with medications?
Can I take this while pregnant or breastfeeding?
Does this product have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Gluco-Control Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Gluco-Control Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vanadium
Interacts with 208 drugsVanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...
Read the full Vanadium monograph → Herb & supplement monographChromium
Interacts with 178 drugsChromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...
Read the full Chromium monograph →Sources & How We Checked
Gluco-Control Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 68 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vanadium 15 references
- Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
- Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
- Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
- Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
- Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
- Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
- Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
- Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
- Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. PubMed
- Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
- Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. PubMed
- Jiang S, Zhou S, Liu H, et al. Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels. Ecotoxicol Environ Saf 2021;213:112028. PubMed
- Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed
Chromium 53 references
- Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
- Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
- Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
- Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
- Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
- Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
- McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
- Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
- Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
- Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
- Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
- Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
- Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
- Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
- Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
- Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
- Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
- John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
- Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
- Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
- Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
- Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
- Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
- Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
- Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
- Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
- Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
- Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
- Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
- Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
- Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
- Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
- Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
- Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
- Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
- Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
- Bunner S and McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299. PubMed
- Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI
- Proctor, D. M., Fredrick, M. M., Scott, P. K., Paustenbach, D. J., and Finley, B. L. The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: a cost-effectiveness case study. Regul.Toxicol Pharmacol 1998;28(1 PubMed
- De Marchi S, Cecchin E, De Marchi SU. Systemic allergic dermatitis resulting from oral administration of chromium with a food supplement. Contact Dermatitis 2014;70(2):123-5. PubMed
- Hedberg YS, Gumulka M, Lind ML, Matura M, Lidén C. Severe occupational chromium allergy despite cement legislation. Contact Dermatitis. 2014;70(5):321-3. PubMed
- Thyssen JP, Jellesen MS, Møller P, Menné T, Johansen JD. Allergic chromium dermatitis from wearing 'chromium-free' footwear. Contact Dermatitis 2014;70(3):185-7. PubMed
- Liu Y, Cotillard A, Vatier C, et al. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One.
- Jamilian M, Asemi Z. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Nutr Metab. 2015;67(1):42-8. PubMed
- Guimarães MM, Carvalho AC, Silva MS. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry. J Trace Elem Med Bi PubMed
- Paiva AN, Lima JG, Medeiros AC, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72. PubMed
- Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015;14:14. PubMed
- Jamilian M, Zadeh Modarres S, Amiri Siavashani M, et al. The influences of chromium supplementation on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome women candidate for in vitro fertilizati
- Alinaghi F, Thyssen JP, Zachariae C, Johansen JD. No immediate effect of regulatory reduction of chromium in leather among adult patients with chromium allergy. Contact Dermatitis 2021;85(5):514-522. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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