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Dietary supplement

Hemp CBD Tincture Classic 25 mg Ingredients & Drug Interactions

by RE: Botanicals

Hemp CBD Tincture Classic 25 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hemp CBD Tincture Classic 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hemp CBD Tincture Classic 25 mg is a dietary supplement by RE: Botanicals with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hemp CBD Tincture Classic 25 mg by RE: Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Hemp CBD Tincture Classic 25 mg by RE: Botanicals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hemp CBD Tincture Classic 25 mg by RE: Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: hemp aerial parts extract, a concentrated extract from the above-ground parts of the hemp plant. The tincture is delivered in a liquid base of medium chain triglyceride oil (a type of fat derived from coconut).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp product and its label doesn't state a use — see Hemp's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for hemp and its effectiveness against constipation, atopic dermatitis (eczema), and familial hypercholesterolemia (a genetic condition affecting cholesterol) is insufficient to rate. That means we don't have enough reliable research to say whether it works for these conditions.

If you're considering it for a specific health issue, ask your pharmacist or doctor about the current research.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods are generally well tolerated in normal amounts, but concentrated extracts like this tincture are less studied. The safety data advises caution with concentrated supplements and extracts.

Serious side effects are rare but have been reported: rare cases of anaphylaxis (severe allergic reaction), and very rare reports of heart rhythm problems. Allergic reactions to hemp seed protein, including hives, facial swelling, breathing trouble, and worsening asthma, have occurred, particularly on first exposure.

There is also a case report of liver inflammation in a young child given very high-dose hemp extract. Because this is a concentrated extract, the safety profile is less established than whole food hemp.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take estrogens (Moderate severity), antihypertensive drugs, ACE inhibitors, anticoagulants or antiplatelet drugs, or medications broken down by your liver's CYP1A2 or CYP3A4 enzymes — all Minor severity. These are broad categories, so use the medication search tool on this page to verify your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take hormone therapy (estrogens), blood pressure medications, blood thinners, or any drug metabolized by your liver, check your medications with our tool before starting this product. The concentrated extract format means fewer safety studies than whole hemp foods.

Talk with your pharmacist about your prescriptions and any allergies to hemp or seeds before you try it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hemp CBD Tincture Classic 25 mg, straight from the product label.

Brand RE: Botanicals
Barcode (UPC) 854265009069
Net contents 3.38 Ounce(s); 100 Milliliter(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 307054
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hemp CBD Tincture Classic 25 mg by RE: Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
100
UPC/BARCODE
854265009069
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat10 Calorie(s)--
Total Fat1 Gram(s)2%
Saturated Fat1 Gram(s)5%
Hemp Aerial Parts Extract25 mg--

Other ingredients: Medium Chain Triglyceride Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

1% for regenerative agriculture

Full spectrum

Certified organic by Pro-Cert

Storage

Storage: Keep in cool, dry place away from light.

Precautions

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition, or are taking any medication.

Keep out of reach of children.

Contains coconut

Seals/Symbols

USDA Organic

Formula

25mg CBD/serving

Organic, U.S.-grown full spectrum hemp

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take drop(s) directly or dilute in small amount of water or juice to drink.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hemp CBD Tincture Classic 25 mg by RE: Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hemp CBD Tincture Classic 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hemp CBD Tincture Classic 25 mg by RE: Botanicals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container100 Amounts shown are per serving.

Hemp Aerial Parts Extract

Interacts with
938 drugs
25 mg per serving Form: Cannabidiol

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hemp CBD Tincture Classic 25 mg by RE: Botanicals Drug Interactions

Want to check YOUR meds against Hemp CBD Tincture Classic 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

Hemp Aerial Parts Extract 938

Individual Drug Interactions

The ingredients in Hemp CBD Tincture Classic 25 mg interact with 938 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hemp CBD Tincture Classic 25 mg interact with drugs. Each result below shows which ingredient is responsible. Hemp Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hemp CBD Tincture Classic 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Aerial Parts Extract6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hemp CBD Tincture Classic 25 mg, from the product label.

RE: Botanicals

See all RE: Botanicals products
Name
RE Botanicals, Inc.
City
Boulder
State
CO
ZipCode
80302
Web Address
www.REBOTANICALS.com
Pharmacist Counseling Corner

Hemp CBD Tincture Classic 25 mg by RE: Botanicals: Common Questions

Does Hemp CBD Tincture Classic 25 mg by RE: Botanicals interact with any medications?
Yes. Based on its ingredients, Hemp CBD Tincture Classic 25 mg has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hemp CBD Tincture Classic 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is hemp CBD safe to use while pregnant or breastfeeding?
The safety data on file for this product does not include information about pregnancy or breastfeeding. Because this is a concentrated extract and less studied than whole hemp food, we'd recommend talking with your doctor or pharmacist before using it during pregnancy or while nursing — they can weigh the risks and benefits for your situation.
Can I take this if I'm allergic to hemp seeds?
Allergic reactions to hemp seeds have been reported, including hives, facial swelling, trouble breathing, and even anaphylaxis in some cases. If you know you have a hemp seed allergy, you should not take this product. If you're unsure, talk to your pharmacist or doctor first.
Does hemp CBD work for eczema or high cholesterol?
The evidence we hold for hemp and atopic dermatitis (eczema) or familial hypercholesterolemia isn't strong enough to say whether it works. For constipation, the same applies — the research is too limited. Your doctor or pharmacist can tell you more about what studies are out there.
What's the difference between this tincture and hemp seed food?
This is a concentrated extract in liquid form, which is less studied for safety than whole hemp seeds or hemp seed oil you'd eat as food. Food amounts of hemp are generally well tolerated, but concentrated supplements like this one carry more caution because we have less safety data on them.
Why does this product interact with so many medications?
Hemp appears to affect how your liver processes certain drugs (through CYP1A2 and CYP3A4 enzymes) and may have additive effects with blood pressure and hormone medications. Because your liver metabolizes hundreds of different drugs through those pathways, the total number of potential interactions is large. That's why checking your specific prescriptions with our tool matters — not every medication you take will actually interact.
Are there any side effects I should know about?
Hemp is generally well tolerated, but serious side effects are rare — they include anaphylaxis and, very rarely, heart rhythm problems. Allergic reactions and liver inflammation have also been reported in isolated cases. Because this is a concentrated extract, side effects are less well understood than with whole hemp food.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hemp CBD Tincture Classic 25 mg label
Go deeper

The Full Monographs Behind Hemp CBD Tincture Classic 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Hemp CBD Tincture Classic 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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