Java Plum 450 mg Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Java Plum 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Java Plum 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, digestive upset and diarrhea, sore throat and mouth health.Based on those ingredients, 186 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Java Plum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Java Plum 450 mg by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Java Plum 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Java Plum 450 mg by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: 450 mg of java plum (jambolan) per capsule. The capsule itself is made from gelatin and water.
Does it work?
Couldn't assess
The evidence we hold on java plum doesn't establish whether it works for diabetes or for venous leg ulcers—the data rated both uses as having insufficient reliable evidence. That doesn't mean it doesn't work; it means the research to prove it isn't there yet.
How safe is it?
Some data gaps
The fruit itself is eaten as food in many parts of the world, but concentrated supplement doses haven't been well studied. The safety data advises against using jambolan supplements during pregnancy and while breastfeeding, so don't take this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check any diabetes or blood sugar medications you take—jambolan can lower blood glucose and may increase the risk of low blood sugar when combined with those drugs. Also check any medications metabolized by the liver enzyme CYP2C9 (which affects a wide range of drugs) before you start, since jambolan may slow that enzyme and raise drug levels.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
Java plum may be worth considering if you're interested in exploring traditional uses for blood sugar, but the evidence isn't established yet. If you take any diabetes medication or other drugs metabolized by your liver, you'll want to check them against the interaction tool on this page and talk with your doctor or pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Java Plum 450 mg, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435205874 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 289218 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Java Plum 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Take 1 capsule, 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Java Plum 450 mg by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Java Plum 450 mg by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Java Plum
Interacts with186 drugs
Jambolan (Syzygium cumini), also called Java plum or black plum, is a tropical fruit tree traditionally used for blood sugar and digestive complaints....
Java Plum monograph & interactionsOther (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Java Plum 450 mg by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
Java Plum 450 mg by TerraVita Premium Collection does interact with medications through its jambolan content.
The most serious concern is with blood sugar–lowering drugs (antidiabetes medications): jambolan can lower blood glucose levels on its own, and adding it to diabetes drugs may increase the risk of low blood sugar (hypoglycemia). You'll want to monitor your blood glucose closely if you're taking any diabetes medication.
Read the full breakdown — every affected drug type, severity by severity
Java plum may also affect how your body breaks down certain other medications. It shows some in vitro evidence of slowing the liver enzyme CYP2C9, which metabolizes a wide range of prescription drugs.
If levels of those drugs build up, they could become less effective or cause side effects. One diabetes drug in particular — sitagliptin (Januvia) — showed reduced blood levels in animal studies, though interestingly, blood glucose control was still improved when the two were used together.
Altogether, these interactions span 186 individual medications. Use the search tool on this page to check your exact medications before you start, and talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Java Plum 450 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Java Plum 450 mg interact with 186 drugs. Click any drug to see the details.
1 of the 1 ingredient in Java Plum 450 mg interact with drugs. Each result below shows which ingredient is responsible. Java Plum
RamelteonRozerem
How Ramelteon interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Ramelteon interactionRepaglinideGlucoNorm, Prandin
How Repaglinide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Repaglinide interactionRosiglitazone MaleateAvandia
How Rosiglitazone Maleate interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates, Antidiabetes Drugs Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Rosiglitazone Maleate interactionSacubitril, ValsartanEntresto
How Sacubitril, Valsartan interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Sacubitril, Valsartan interactionSaxagliptinOnglyza
How Saxagliptin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Saxagliptin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Saxagliptin, Metformin Xr interactionSemaglutideOzempic, Rybelsus, Wegovy
How Semaglutide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Semaglutide interactionSildenafilRevatio
How Sildenafil interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Sildenafil interactionSildenafil CitrateViagra
How Sildenafil Citrate interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Sildenafil Citrate interactionSimvastatin, SitagliptinJuvisync
How Simvastatin, Sitagliptin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs, Sitagliptin (januvia) Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Simvastatin, Sitagliptin interactionSiponimodMayzent
How Siponimod interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Siponimod interactionSitagliptinJanuvia, Zituvio
How Sitagliptin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs, Sitagliptin (januvia) Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Sitagliptin interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs, Sitagliptin (januvia) Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Sitagliptin, Metformin interactionSotagliflozinInpefa
How Sotagliflozin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Sotagliflozin interactionSulfamethoxazoleGantanol
How Sulfamethoxazole interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Sulfamethoxazole interactionSulfamethoxazole, TrimethoprimBactrim, Bactrim DS, Bactrim IV, Cotrim, Cotrim DS, Cotrimix +9 more
How Sulfamethoxazole, Trimethoprim interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Sulfamethoxazole, Trimethoprim interactionTamoxifen CitrateNolvadex, Soltamox
How Tamoxifen Citrate interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Tamoxifen Citrate interactionTapentadolNucynta, Nucynta ER
How Tapentadol interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Tapentadol interactionTirzepatideMounjaro, Zepbound
How Tirzepatide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Tirzepatide interactionTobutamideMobenol
How Tobutamide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Tobutamide interactionTolazamideTolinase
How Tolazamide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Tolazamide interactionTolbutamideOrinase
How Tolbutamide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates, Antidiabetes Drugs Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Tolbutamide interactionTorsemideDemadex, Soaanz
How Torsemide interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Torsemide interactionTrimipramineRhotrimine, Surmontil, Trimip, Trimp, Tripramine
How Trimipramine interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Trimipramine interactionTroglitazoneRezulin
How Troglitazone interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Troglitazone interactionValdecoxibBextra
How Valdecoxib interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Valdecoxib interactionValsartanDiovan, Prexxartan
How Valsartan interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Valsartan interactionVildagliptinGalvus
How Vildagliptin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumAntidiabetes Drugs Moderate
Interaction Summary
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.
Read the full Java Plum + Vildagliptin interactionVoriconazoleVfend
How Voriconazole interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Voriconazole interactionWarfarinWarfarin
How Warfarin interacts with Java Plum 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Java PlumCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
There is some in vitro evidence that jambolan can inhibit CYP2C9.
Read the full Java Plum + Warfarin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Java Plum 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Java Plum
Antidiabetes Drugs
Animal research shows that jambolan seed and bark extracts can lower blood glucose levels. Theoretically, jambolan might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
Cytochrome P450 2C9 (Cyp2C9) Substrates
There is some in vitro evidence that jambolan can inhibit CYP2C9. Theoretically, concomitant use of jambolan with CYP2C9 substrates may increase levels of drugs metabolized by CYP2C9.
Sitagliptin (Januvia)
Animal research shows that jambolan seed extract reduces the sitagliptin maximum plasma concentration and area under the curve by 39% and 22%, respectively. However, blood glucose levels were actually reduced to a greater extent in mice taking jambolan and sitagliptin in combination when compared with either product taken alone. Theoretically, jambolan seed extract might alter the clearance of sitagliptin, although this may not alter the clinical effects of sitagliptin.
Brand information
Manufacturer and brand details for Java Plum 450 mg, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Java Plum 450 mg by TerraVita Premium Collection: Common Questions
Does Java Plum 450 mg by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take java plum if I'm pregnant or breastfeeding?
Does java plum actually work for blood sugar?
What is java plum?
Will this increase my risk of low blood sugar if I take diabetes medication?
Are there any side effects from taking java plum?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Java Plum 450 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Java Plum 450 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Java Plum 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Jambolan 7 references
- Teixeira CC, Weinert LS, Barbosa DC, et al. Syzygium cumini (L.) Skeels in the treatment of type 2 diabetes. Diabetes Care 2004;27:3019-20.
- Sharma SB, Nasir A, Prabhu KM, et al. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003;85:201-6. PubMed
- Sridhar SB, Sheetal UD, Pai MR, Shastri MS. Preclinical evaluation of the antidiabetic effect of Eugenia jambolana seed powder in streptozotocin-diabetic rats. Braz J Med Biol Res 2005;38:463-8. PubMed
- Villasenor IM, Lamadrid MR. Comparative anti-hyperglycemic potentials of medicinal plants. J Ethnopharmacol 2006;104:129-31. PubMed
- Chinni S, Dubala A, Kosaraju J, et al. Effect of crude extract of Eugenia jambolana Lam. on human cytochrome P450 enzymes. Phytother Res 2014;28(11):1731-4. doi: 10.1002/ptr.5137.
- Vora A, Varghese A, Kachwala Y, et al. Eugenia jambolana extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: A pharmacokinetic and a pharmacodynamic herb-drug interaction study. J Tradit Complement Med. 2 PubMed
- Araújo GR, Teles BSBS, Xoteslem GC, Gratieri T, Fortes RC, Novaes MR. Randomized, double-blind clinical trial comparing the healing of stasis ulcers in lower limbs with standard hydrocolloid gel dressings and with dressings with Syzygium cumini extract. P PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC