L-W Ingredients & Drug Interactions
by Pure Herbs
What is this page for?
First and foremost: checking L-W against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-W is a dietary supplement by Pure Herbs with 6 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis and respiratory irritation.Based on those ingredients, 2,044 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow Root Extract, Gentian Root Extract, Mullein Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-W by Pure Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with L-W by Pure Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-W by Pure Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
L-W contains six active ingredients in liquid form: mullein leaf extract, marshmallow root extract, lobelia aerial parts extract, gentian root extract, blessed thistle aerial parts extract, and yerba santa leaf extract. These are traditional botanical extracts blended together; the product lists no inactive ingredients beyond the liquid base itself.
Does it work?
Not established
The evidence for what these ingredients can do is not established in the data we hold. Mullein leaf has been studied for bronchitis, asthma, migraine headache, cough, and diarrhea, but the evidence is insufficient to rate it for any of these uses.
Marshmallow root, gentian root, and yerba santa leaf all show insufficient evidence for their intended uses as well. Lobelia aerial parts are rated possibly ineffective for smoking cessation.
Blessed thistle shows insufficient evidence for dyspepsia. If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist.
How safe is it?
Well-documented data
Mullein leaf and marshmallow root are generally well tolerated for short-term use, but human safety data are limited for both. Lobelia aerial parts carry a strong caution — lobelia can be toxic, especially at higher doses.
Doses as low as 50 mg have caused nausea, vomiting, diarrhea, dizziness, and throat irritation; at 600 mg or higher, lobelia leaf can cause serious toxicity including rapid heart rate, dangerously low blood pressure, and death. Blessed thistle is often well tolerated in small amounts but can cause stomach irritation and vomiting at high doses (more than 5 grams per cup of tea).
Gentian root is generally tolerated in small amounts but may upset the stomach. Blessed thistle can also trigger allergic reactions (dermatitis) in people sensitive to plants in the ragweed family.
Meds to double-check
Moderate interaction found
Before taking L-W, double-check with your doctor or pharmacist if you take lithium (Moderate risk of toxicity from marshmallow root, lobelia, and yerba santa), blood thinners or antiplatelet drugs like warfarin or aspirin (Minor risk from mullein and marshmallow), blood pressure medications (Moderate risk from gentian), or stomach acid drugs including H2-blockers, antacids, or PPIs (Minor risk from blessed thistle). Also, space this product 30–60 minutes away from other oral medications to avoid absorption problems.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
L-W is a multiherbal liquid blend with limited evidence for the conditions it addresses and several ingredients that carry safety cautions or interact with common medications. If you take lithium, blood thinners, blood pressure drugs, or stomach acid medications, check with your doctor or pharmacist before starting this product.
Anyone with lobelia sensitivity concerns or a history of heart or blood pressure issues should discuss it with their healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-W, straight from the product label.
| Brand | Pure Herbs |
|---|---|
| Net contents | 1 Fluid Ounce(s); 30 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2022 |
| DSLD ID | 279947 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-W by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1865 mg | -- |
| Mullein Leaf Extract | 0 NP | -- |
| Marshmallow Root Extract | 0 NP | -- |
| Lobelia Aerial Parts Extract | 0 NP | -- |
| Gentian Root Extract | 0 NP | -- |
| Blessed Thistle Aerial Parts Extract | 0 NP | -- |
| Yerba Santa leaf extract | 0 NP | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.
Shake well before use
Formulation
Helps to maintain a healthy respiratory system. Supports healthy lung function.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.
Discontinue use and consult with your doctor if any adverse reactions occur.
Keep out of reach of children
Brand IP Statement(s)
Pure Herbs, Ltd. Natural Herbal Extracts
FDA Statement of Identity
Dietary Supplement
General Statements
"No expense has been spared to provide the finest nature has to offer."
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-W by Pure Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-W by Pure Herbs
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-W by Pure Herbs Drug Interactions
HelloPharmacist Interaction Report
L-W by Pure Herbs interacts with medications through its mullein leaf, marshmallow root, lobelia aerial parts, gentian root, blessed thistle aerial parts, and yerba santa leaf extracts.
The most serious interaction is a Moderate risk with lithium — three ingredients (marshmallow root, lobelia aerial parts, and yerba santa leaf) may reduce how your kidneys clear lithium, raising levels and risking toxicity. If you take lithium, your doctor may need to adjust your dose.
Read the full breakdown — every affected drug type, severity by severity
Minor interactions occur with blood thinners (anticoagulant/antiplatelet drugs) through mullein leaf and marshmallow root, and with stomach acid drugs through blessed thistle — H2-blockers, antacids, and proton pump inhibitors (PPIs) — because blessed thistle may increase stomach acid and reduce their effectiveness. Marshmallow root can also interfere with how your body absorbs oral medications if taken at the same time; space it 30–60 minutes apart.
GenMarshmallow root also carries a Moderate interaction with antihypertensive drugs (blood pressure medications), since it may theoretically lower blood pressure further and raise the risk of dangerously low readings.
Check your exact medications with the search tool on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-W?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-W interact with 2,044 drugs. Click any drug to see the details.
6 of the 6 ingredients in L-W interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Root Extract Gentian Root Extract Mullein Leaf Extract Blessed Thistle Aerial Parts Extract Lobelia Aerial Parts Extract Yerba Santa leaf extract
AcebutololRhotral, Sectral
How Acebutolol interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Acebutolol interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Acetazolamide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Aliskiren interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Ambrisentan interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amiloride interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amiloride, Hydrochlorothiazide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Benzoate interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Besilate interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Besylate interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Besylate, Benazepril interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine, Celecoxib interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Ammonium Chloride interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Ammonium Chloride interactionAprocitentanTryvio
How Aprocitentan interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Aprocitentan interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Atenolol interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Atenolol, Chlortalidone interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Atenolol, Chlorthalidone interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Atenolol, Chlorthalidone interactionAzilsartanEdarbi
How Azilsartan interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Azilsartan interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Azilsartan, Chlorthalidone interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Benazepril interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Benazepril, Hydrochlorothiazide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bendroflumethiazide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bendroflumethiazide, Nadolol interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Benzthiazide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Betaxolol interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bisoprolol interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bisoprolol, Hydrochlorothiazide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bosentan interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bosentan interactionBumetanideBurinex
How Bumetanide interacts with L-W — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Bumetanide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Bumetanide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-W with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Marshmallow Root Extract
Lithium
Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.
Anticoagulant/Antiplatelet Drugs
Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.
Oral Drugs
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.
Gentian Root Extract
Antihypertensive Drugs
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.
Mullein Leaf Extract
Anticoagulant/Antiplatelet Drugs
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.
Blessed Thistle Aerial Parts Extract
Antacids
Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.
H2-Blockers
Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.
Proton Pump Inhibitors (Ppis)
Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.
Lobelia Aerial Parts Extract
Lithium
Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Yerba Santa leaf extract
Lithium
Yerba santa is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, yerba santa might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for L-W, from the product label.
Pure Herbs
See all Pure Herbs products- Name
- Pure Herbs, Ltd.
- City
- Sterling Heights
- State
- MI
- Phone Number
- (800) 860-4372
- Web Address
- www.pureherbs.com
L-W by Pure Herbs: Common Questions
Does L-W by Pure Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe during pregnancy or while breastfeeding?
What's lobelia in this product, and why does it have such strong warnings?
Does this product actually work for anything?
Can I take this with my other oral medications?
What are the most common side effects?
Who should avoid this product entirely?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-W is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-W’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Mullein
Interacts with 122 drugsMullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...
Read the full Mullein monograph → Herb & supplement monographMarshmallow
Interacts with 2,040 drugsMarshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...
Read the full Marshmallow monograph → Herb & supplement monographLobelia
Interacts with 1 drugLobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...
Read the full Lobelia monograph → Herb & supplement monographGentian
Interacts with 172 drugsGentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...
Read the full Gentian monograph → Herb & supplement monographBlessed Thistle
Interacts with 36 drugsBlessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...
Read the full Blessed Thistle monograph → Herb & supplement monographYerba Santa
Interacts with 1 drugYerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientifi...
Read the full Yerba Santa monograph →Sources & How We Checked
L-W's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Mullein 2 references
- Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
- Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.
Marshmallow 5 references
- Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.
Lobelia 6 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
- Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
- Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed
Gentian 5 references
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
- Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
- Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
- Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.
Blessed Thistle 2 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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