Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Lipo-Complex Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

Lipo-Complex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lipo-Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lipo-Complex is a dietary supplement by Progressive Professional from Progressive Laboratories with 5 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 862 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Green Beet powder, freeze dried Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lipo-Complex by Progressive Professional from Progressive Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Lipo-Complex by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lipo-Complex by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Lipo-Complex has five active ingredients: pepsin (a digestive enzyme), bile salts, freeze-dried liver, pancreatic enzyme concentrate, and green beet powder. Together they're meant to support fat digestion and nutrient absorption.

The product also contains rice flour, gelatin, and vegetable lubricant as inactive ingredients (fillers and capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“digestive aid”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (Beet) (Natural Medicines).
  • On file: Exercise-induced muscle soreness — rated "Possibly Effective" (Beet) (Natural Medicines).

We have effectiveness data for green beet powder only — it's possibly effective for athletic performance and exercise-induced muscle soreness. For chronic obstructive pulmonary disease (COPD), it's possibly ineffective.

For cholesterol and cognitive function, the evidence isn't established in our data. We hold no effectiveness ratings for pepsin, bile salts, liver, or pancreatic enzyme concentrate.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Liver Extract Beet

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated in most adults, though it may cause digestive upset or allergic reactions. Safety has not been established in pregnancy, so it's best avoided unless prescribed; there's little safety data during breastfeeding, so medical advice is needed before use.

Green beet powder is widely eaten as food and generally well tolerated short-term, but concentrated supplements lack safety data — use with caution. Most common side effects are red stools and urine, which are harmless.

Rarely, large amounts may cause low blood calcium (hypocalcemia) or kidney damage.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Liver Extract Beet

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Beet, Liver Extract.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 863 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Lipo-Complex, check your medications against CYP3A4 substrates (a very large group — your pharmacist can tell you if yours are in it), CYP1A2 substrates, and blood pressure medications. These are the drug types with documented interactions with green beet powder in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Lipo-Complex is meant for people looking to support fat digestion with digestive enzymes and beet. If you take any prescription medications, especially ones that interact with CYP3A4 or CYP1A2, or blood pressure drugs, run your exact list through the checker before starting.

Talk to your pharmacist — they can help you decide if the timing or dose works with your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lipo-Complex, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821009889
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261887
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lipo-Complex by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
351821009889
IngredientAmount% DV
Pepsin30 mg--
Bile Salts10 mg--
freeze dried Liver10 mg--
Pancreatic enzyme concentrate160 mg--
Green Beet powder100 mg--

Other ingredients: Rice Flour, Gelatin, Vegetable Lubricant

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a digestive aid for adults, one capsule with each meal, as needed, or more, as directed by a health care professional.

Precautions

Sold only for dispensing by a licensed health professional.

Pregnant and/or lactating women should consult their physician prior to use.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of the reach of children.

Contains: Milk

Formulation

Equivalent in enzymatic activity to 10X USP.

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Lipid digestive support

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Brand IP Statement(s)

Progressive Professional from Progressive Laboratories

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lipo-Complex by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lipo-Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lipo-Complex by Progressive Professional from Progressive Laboratories

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pepsin

No known
interactions
30 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Bile Salts

10 mg per serving

Freeze dried Liver

Interacts with
3 drugs
10 mg per serving

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Freeze dried Liver monograph & interactions

Pancreatic enzyme concentrate

160 mg per serving

Green Beet powder

Interacts with
861 drugs
100 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Green Beet powder monograph & interactions

Other (inactive) ingredients: Rice Flour, Gelatin, Vegetable Lubricant. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lipo-Complex by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against Lipo-Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
862Drugs
643 Moderate 219 Minor

Ingredients driving the most interactions

Green Beet powder 861
freeze dried Liver 3

Individual Drug Interactions

The ingredients in Lipo-Complex interact with 862 drugs. Click any drug to see the details.

2 of the 5 ingredients in Lipo-Complex interact with drugs. Each result below shows which ingredient is responsible. Green Beet powder freeze dried Liver

Each ingredient & the kinds of drugs it affects

For each ingredient in Lipo-Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Green Beet powder3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Green Beet powder full monograph & interactions

freeze dried Liver2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
freeze dried Liver full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lipo-Complex, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

Lipo-Complex by Progressive Professional from Progressive Laboratories: Common Questions

Does Lipo-Complex by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, Lipo-Complex has a known interaction with 862 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lipo-Complex contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Pepsin should be avoided in pregnancy unless your doctor prescribes it. During breastfeeding, there's too little safety data — talk with your doctor or pharmacist first. We don't have safety data on the other ingredients for pregnancy or breastfeeding, so discuss them with your healthcare provider for personalized advice.
What are these digestive enzymes supposed to do?
Pepsin, bile salts, and pancreatic enzymes are meant to help break down fats and other nutrients so your body can absorb them better. Green beet powder is included for possible benefits with exercise performance and muscle soreness.
Will my poop turn red?
Yes, red stools and red urine are the most common side effects from the beet powder in this product, and they're completely harmless. Your stools may also turn black rarely.
Is beet powder in this supplement safe?
Beet as a food is safe and well tolerated, but this product uses a concentrated supplement form, and there's limited safety data on concentrated beet supplements. Use with caution, especially if you're taking large amounts.
Can I take this with my blood pressure medication?
Beet powder may theoretically lower blood pressure slightly, but one clinical study found no significant effect. Still, check with your pharmacist before combining it with blood pressure drugs to be safe.
I'm allergic to enzymes. Is pepsin safe for me?
Pepsin may cause allergic reactions in some people, especially those with sensitivity to proteolytic enzymes. If you have a known allergy, skip this product and talk to your pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lipo-Complex is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lipo-Complex label
Go deeper

The Full Monographs Behind Lipo-Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Liver Extract

Interacts with 3 drugs

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...

Read the full Liver Extract monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph →
Sources

Sources & How We Checked

Lipo-Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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