Natadrol Ingredients & Drug Interactions
by LG Sciences
What is this page for?
First and foremost: checking Natadrol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Natadrol is a dietary supplement by LG Sciences with 6 active ingredients. Its ingredients are commonly taken for immune support, fever, blood sugar support.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androgenic Fraction, Anabolic Factor. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Natadrol by LG Sciences
Ask about any prescription or over-the-counter medication and we check it for interactions with Natadrol by LG Sciences — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Natadrol by LG Sciences
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Natadrol has 6 ingredients listed on the label. The active components include an Androgenic Fraction identified as Tinospora cordifolia, an Anabolic Factor identified as Cissus quadrangularis, and a blend called pSARM CoFactors.
You'll also find Hibiscus Rosa-Sinensis and Curculigo Orchioides, though we hold no interaction data for these. The product also contains several inactive ingredients (microcrystalline cellulose, magnesium stearate, and food colorings) that serve as fillers and binders in the capsule.
Does it work?
Not established
The Tinospora cordifolia in this product is possibly effective for type 2 diabetes—clinical research shows it can lower fasting blood sugar and glycated hemoglobin (a marker of long-term blood sugar control). The Cissus quadrangularis component is also possibly effective for weight loss, with small studies suggesting it may reduce fasting blood sugar in people who are overweight or obese.
For other conditions like hay fever, asthma, athletic performance, cancer, and hepatitis, we don't hold enough reliable evidence to rate these ingredients.
How safe is it?
Well-documented data
When taken by mouth, Tinospora cordifolia is generally well tolerated, though headache and nasal pain have been reported in trials. More seriously, liver injury—including autoimmune hepatitis, acute hepatitis, and in rare cases liver failure—has been documented after taking this ingredient alone or in combination supplements.
Of 49 reported cases, a small number required liver transplant or were fatal. The ingredient should be used carefully and only under guidance.
Cissus quadrangularis is well tolerated in short-term use; headache and insomnia have been reported, but at rates similar to placebo. Its long-term safety hasn't been well studied.
Neither ingredient has adequate safety data in pregnancy or while breastfeeding—both should be avoided in these situations.
Meds to double-check
Moderate interaction found
Before taking Natadrol, double-check with your doctor or pharmacist if you take antidiabetes medications (blood sugar drugs)—both the Tinospora and Cissus in this product can theoretically increase low blood sugar risk. Also alert your healthcare provider if you're on immunosuppressant drugs, as the Tinospora fraction may reduce their effectiveness.
Additionally, if you take medications metabolized by your liver's CYP2D6, CYP2C19, CYP1A2, or CYP2C9 pathways—a broad group that includes many antidepressants, heart medications, and pain relievers—the Tinospora ingredient may raise your drug levels and side effects.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with blood sugar control or weight management based on its Tinospora and Cissus components, but it carries real risks: potential liver injury from Tinospora cordifolia and significant interactions with medications your liver processes and with diabetes drugs. If you take any prescription medications, immunosuppressants, or diabetes medications, check them against this product's ingredients with your own doctor or pharmacist before starting.
Avoid it if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Natadrol, straight from the product label.
| Brand | LG Sciences |
|---|---|
| Barcode (UPC) | 897686002523 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2013 |
| DSLD ID | 19774 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Natadrol by LG Sciences, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0 NP | -- |
| Natadrol Complex | 550 mg | -- |
| Androgenic Fraction | 0 NP | -- |
| Anabolic Factor | 0 NP | -- |
| pSARM CoFactors | 0 NP | -- |
| Hibiscus Rosa-Sinensis | 0 NP | -- |
| Curculigo Orchioides | 0 NP | -- |
Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, FD&C Blue Dye #1, FD&C Red Dye #40, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
This completely natural product is so potent at binding to, and stimulating the androgen receptor, that we suggest a mild Post Cycle Therapy for 1-2 weeks following a 4-8 week cycle using an over-the-counter product like our Formadrol(R), T-911(R), or similar products.
NATADROL(R) Natadrol(R) may be the strongest prohormone replacement on the market today. Natadrol(R) is a natural, non-steroidal androgen that mimics the effects of strong prohormones; however, the ingredients in Natadrol(R) should not cause users to test positive on any drug test.
Storage
Recommendation: As a dietary supplement designed to replace prohormones, take 4-6 capsules per day in divided doses with your meals. Use for 4-8 week cycles. We recommend a mild over-the-counter Post Cycle Therapy with this product after your cycle to kick-start your natural testosterone production.
Precautions
Discontinue two weeks prior to surgery, do not exceed recommended dosage.
Although this is NOT a steroidal product it will have the same risks and benefits of common prohormones. It should not in any way make you fail a drug test for anabolic steroids, but please always check with your governing body should you have a question.
WARNING: KEEP OUT OF REACH OF CHILDREN Product use should be strictly limited to healthy adults above the age of 18.
Do not use this product if you are at risk for heart disease, high blood pressure, heart, kidney, thyroid, psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder or stroke.
Do not take if you are pregnant or nursing.
Discontinue use if there are any side effects.
Always consult your healthcare professional before use especially if: you are taking any prescription drugs, beginning any new diet and exercise program, or you have any health concerns or pre-existing conditions.
*although we know of no possible way that this product would make you test positive, please check with your governing body should you have any questions.
General Statements
1) Phytomedicine. 2009 Jun;16(6-7):679-82. Epub 2008 Dec 20. Androgenic action of Tinospora cordifolia ethanolic extract..., Kapur P, Department of Biotechnology, Indian Institute of Technology Roorkee
NON-STEROIDAL ANDROGEN
Product efficacy depends on proper diet and exercise.
Made in USA
"Starts Working Instantly" "As Androgenic As OH-Test" "Can Be Used By Drug Tested Athletes"*
Formulation
Natadrol(R) does not contain any anabolic steroids but does show in the scientific literature to bind to and activate the androgen receptor.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Natadrol by LG Sciences label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Natadrol by LG Sciences
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Natadrol Complex
Androgenic Fraction
Interacts with612 drugs
Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Ea...
Androgenic Fraction monograph & interactionsAnabolic Factor
Interacts with86 drugs
Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...
Anabolic Factor monograph & interactionsPSARM CoFactors
- › Hibiscus Rosa-Sinensis
- › Curculigo Orchioides
Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, FD&C Blue Dye #1, FD&C Red Dye #40, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
Natadrol by LG Sciences Drug Interactions
HelloPharmacist Interaction Report
Natadrol by LG Sciences contains ingredients with documented interactions affecting multiple medications.
The primary concern comes from its Androgenic Fraction (Tinospora cordifolia) and Anabolic Factor (Cissus quadrangularis), which interact with blood sugar medications—both can theoretically raise the risk of low blood sugar (hypoglycemia) when combined with antidiabetes drugs. The Androgenic Fraction presents the most serious documented interactions: it may increase levels of several types of drugs your liver breaks down (CYP2D6, CYP2C19, CYP1A2, and CYP2C9 substrates), and it may interfere with immunosuppressant medications.
Read the full breakdown — every affected drug type, severity by severity
The Androgenic Fraction's enzyme-inhibiting effects are based on lab and animal research so far—they haven't been confirmed in people yet. However, animal studies of this ingredient at high doses showed it raised blood levels of glyburide, a diabetes medication, suggesting the interaction is plausible.
Additionally, the Androgenic Fraction may reduce how well immune-suppressing drugs work.
We could not check three ingredients in this product: the Proprietary Blend, Natadrol Complex, pSARM CoFactors, Hibiscus Rosa-Sinensis, and Curculigo Orchioides—we hold no interaction data for them.
Altogether, these interactions span 612 individual medications. Before you start Natadrol, run your exact medications through the checker on this page to see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Natadrol?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Natadrol interact with 612 drugs. Click any drug to see the details.
2 of the 6 ingredients in Natadrol interact with drugs. Each result below shows which ingredient is responsible. Androgenic Fraction Anabolic Factor
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionImmunosuppressants Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
Read the full Androgenic Fraction + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2c9 (cyp2c9) Substrates, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
Read the full Androgenic Fraction + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Natadrol — through 2 ingredients. Tap an ingredient for the detail:
Androgenic FractionAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Androgenic Fraction + Acarbose interactionAnabolic FactorAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Anabolic Factor + Acarbose interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Androgenic Fraction + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Androgenic Fraction + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Androgenic Fraction + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Natadrol — through 1 ingredient. Tap an ingredient for the detail:
Androgenic FractionCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
Read the full Androgenic Fraction + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Natadrol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Androgenic Fraction
Antidiabetes Drugs
Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.
Anabolic Factor
Antidiabetes Drugs
Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.
Brand information
Manufacturer and brand details for Natadrol, from the product label.
LG Sciences
See all LG Sciences products- Name
- LG Sciences, LLC
- City
- Las Vegas
- State
- NV
- Phone Number
- (702) 232-8522
Natadrol by LG Sciences: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Natadrol’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Tinospora Cordifolia
Interacts with 612 drugsTinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...
Read the full Tinospora Cordifolia monograph → Herb & supplement monographCissus Quadrangularis
Interacts with 86 drugsCissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...
Read the full Cissus Quadrangularis monograph →Sources & How We Checked
Natadrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tinospora Cordifolia 16 references
- Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
- Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
- Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
- Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
- Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
- Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
- Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
- Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
- Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
- Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
- Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
- Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
- Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
- May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.
See these in context on the Tinospora Cordifolia monograph →
Cissus Quadrangularis 5 references
- Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
- Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
- Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
- Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
- Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed
See these in context on the Cissus Quadrangularis monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC