Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Natadrol Ingredients & Drug Interactions

by LG Sciences

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Natadrol is a dietary supplement by LG Sciences with 6 active ingredients. Its ingredients are commonly taken for immune support, fever, blood sugar support.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androgenic Fraction, Anabolic Factor. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Natadrol by LG Sciences

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “pSARM CoFactors” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Natadrol has 6 ingredients listed on the label. The active components include an Androgenic Fraction identified as Tinospora cordifolia, an Anabolic Factor identified as Cissus quadrangularis, and a blend called pSARM CoFactors.

You'll also find Hibiscus Rosa-Sinensis and Curculigo Orchioides, though we hold no interaction data for these. The product also contains several inactive ingredients (microcrystalline cellulose, magnesium stearate, and food colorings) that serve as fillers and binders in the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: androgen receptor stimulation and prohormone replacement.
  • We looked for evidence on: Athletic performance, Muscle strength, Sexual desire, anabolic effects, testosterone support, lean mass.
  • The closest evidence on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Sexual desire.
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The Tinospora cordifolia in this product is possibly effective for type 2 diabetes—clinical research shows it can lower fasting blood sugar and glycated hemoglobin (a marker of long-term blood sugar control). The Cissus quadrangularis component is also possibly effective for weight loss, with small studies suggesting it may reduce fasting blood sugar in people who are overweight or obese.

For other conditions like hay fever, asthma, athletic performance, cancer, and hepatitis, we don't hold enough reliable evidence to rate these ingredients.

The evidence, ingredient by ingredient Tinospora Cordifolia Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, Tinospora cordifolia is generally well tolerated, though headache and nasal pain have been reported in trials. More seriously, liver injury—including autoimmune hepatitis, acute hepatitis, and in rare cases liver failure—has been documented after taking this ingredient alone or in combination supplements.

Of 49 reported cases, a small number required liver transplant or were fatal. The ingredient should be used carefully and only under guidance.

Cissus quadrangularis is well tolerated in short-term use; headache and insomnia have been reported, but at rates similar to placebo. Its long-term safety hasn't been well studied.

Neither ingredient has adequate safety data in pregnancy or while breastfeeding—both should be avoided in these situations.

Side effects, ingredient by ingredient Tinospora Cordifolia Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Tinospora Cordifolia, Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 612 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Natadrol, double-check with your doctor or pharmacist if you take antidiabetes medications (blood sugar drugs)—both the Tinospora and Cissus in this product can theoretically increase low blood sugar risk. Also alert your healthcare provider if you're on immunosuppressant drugs, as the Tinospora fraction may reduce their effectiveness.

Additionally, if you take medications metabolized by your liver's CYP2D6, CYP2C19, CYP1A2, or CYP2C9 pathways—a broad group that includes many antidepressants, heart medications, and pain relievers—the Tinospora ingredient may raise your drug levels and side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with blood sugar control or weight management based on its Tinospora and Cissus components, but it carries real risks: potential liver injury from Tinospora cordifolia and significant interactions with medications your liver processes and with diabetes drugs. If you take any prescription medications, immunosuppressants, or diabetes medications, check them against this product's ingredients with your own doctor or pharmacist before starting.

Avoid it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natadrol, straight from the product label.

Brand LG Sciences
Barcode (UPC) 897686002523
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19774
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natadrol by LG Sciences, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
897686002523
IngredientAmount% DV
Proprietary Blend0 NP--
Natadrol Complex550 mg--
Androgenic Fraction0 NP--
Anabolic Factor0 NP--
pSARM CoFactors0 NP--
Hibiscus Rosa-Sinensis0 NP--
Curculigo Orchioides0 NP--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, FD&C Blue Dye #1, FD&C Red Dye #40, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

This completely natural product is so potent at binding to, and stimulating the androgen receptor, that we suggest a mild Post Cycle Therapy for 1-2 weeks following a 4-8 week cycle using an over-the-counter product like our Formadrol(R), T-911(R), or similar products.

NATADROL(R) Natadrol(R) may be the strongest prohormone replacement on the market today. Natadrol(R) is a natural, non-steroidal androgen that mimics the effects of strong prohormones; however, the ingredients in Natadrol(R) should not cause users to test positive on any drug test.

Storage

Recommendation: As a dietary supplement designed to replace prohormones, take 4-6 capsules per day in divided doses with your meals. Use for 4-8 week cycles. We recommend a mild over-the-counter Post Cycle Therapy with this product after your cycle to kick-start your natural testosterone production.

Precautions

Discontinue two weeks prior to surgery, do not exceed recommended dosage.

Although this is NOT a steroidal product it will have the same risks and benefits of common prohormones. It should not in any way make you fail a drug test for anabolic steroids, but please always check with your governing body should you have a question.

WARNING: KEEP OUT OF REACH OF CHILDREN Product use should be strictly limited to healthy adults above the age of 18.

Do not use this product if you are at risk for heart disease, high blood pressure, heart, kidney, thyroid, psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder or stroke.

Do not take if you are pregnant or nursing.

Discontinue use if there are any side effects.

Always consult your healthcare professional before use especially if: you are taking any prescription drugs, beginning any new diet and exercise program, or you have any health concerns or pre-existing conditions.

*although we know of no possible way that this product would make you test positive, please check with your governing body should you have any questions.

General Statements

1) Phytomedicine. 2009 Jun;16(6-7):679-82. Epub 2008 Dec 20. Androgenic action of Tinospora cordifolia ethanolic extract..., Kapur P, Department of Biotechnology, Indian Institute of Technology Roorkee

NON-STEROIDAL ANDROGEN

Product efficacy depends on proper diet and exercise.

Made in USA

"Starts Working Instantly" "As Androgenic As OH-Test" "Can Be Used By Drug Tested Athletes"*

Formulation

Natadrol(R) does not contain any anabolic steroids but does show in the scientific literature to bind to and activate the androgen receptor.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

See for yourself

Natadrol by LG Sciences label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Natadrol by LG Sciences

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Natadrol Complex

550 mg per serving

Androgenic Fraction

Interacts with
612 drugs
0 NP per serving Form: Tinospora Cordifolia

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Ea...

Androgenic Fraction monograph & interactions

Anabolic Factor

Interacts with
86 drugs
0 NP per serving Form: Cissus Quadrangularis

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Anabolic Factor monograph & interactions

PSARM CoFactors

0 NP per serving
  • › Hibiscus Rosa-Sinensis
  • › Curculigo Orchioides

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, FD&C Blue Dye #1, FD&C Red Dye #40, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natadrol by LG Sciences Drug Interactions

Want to check YOUR meds against Natadrol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
612Drugs
612 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Natadrol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Androgenic Fraction6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D

Anabolic Factor1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Natadrol, from the product label.

LG Sciences

See all LG Sciences products
Name
LG Sciences, LLC
City
Las Vegas
State
NV
Phone Number
(702) 232-8522
Pharmacist Counseling Corner

Natadrol by LG Sciences: Common Questions

Does Natadrol by LG Sciences interact with any medications?
Yes. Based on its ingredients, Natadrol has a known interaction with 612 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natadrol contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Natadrol actually work for weight loss?
Its Cissus quadrangularis ingredient is possibly effective for obesity based on small clinical studies showing it can reduce fasting blood sugar in people who are overweight or obese. That said, the evidence is limited, and we don't have a strong track record for the product as a whole.
Can I take Natadrol if I have diabetes?
The Tinospora and Cissus in this product may lower your blood sugar, which is actually why one of them is studied for diabetes—but that also means it could cause dangerously low blood sugar if you're already on diabetes medication. Talk to your doctor or pharmacist before starting; they'll need to know your exact medications and may need to adjust your dose.
Is Natadrol safe while I'm pregnant or breastfeeding?
No. The safety data is not there for either situation—Tinospora cordifolia and Cissus quadrangularis should both be avoided during pregnancy and while breastfeeding. Talk to your doctor or pharmacist about alternatives.
What are the most common side effects?
Tinospora cordifolia has caused headache and nasal pain in trials, while Cissus quadrangularis users have reported headache, insomnia, and occasionally stomach upset—but all of these occurred at rates no higher than placebo in studies. The more serious concern is rare liver injury reported with Tinospora cordifolia, which is why this ingredient needs careful use and monitoring.
Is there any liver risk I should know about?
Yes. Tinospora cordifolia, one of the main ingredients, has been linked to liver injury in case reports—including autoimmune hepatitis, acute hepatitis, and in rare cases liver failure. Most cases occurred after 1.5 to 3 months of use. This ingredient should be used under guidance and you should watch for signs like yellowing skin or dark urine.
What's in the 'Proprietary Blend' and 'Natadrol Complex'?
Those are blended ingredient groups, and the manufacturer doesn't break down their exact contents on the label. We don't hold interaction data for them, so you can't check them against your medications through our tools.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natadrol is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natadrol label
Sources

Sources & How We Checked

Natadrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tinospora Cordifolia 16 references
  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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