Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Nitric Oxide Booster Ingredients & Drug Interactions

by SNAP

Nitric Oxide Booster label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nitric Oxide Booster against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nitric Oxide Booster is a dietary supplement by SNAP with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 1,417 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nitric Oxide Booster by SNAP

Ask about any prescription or over-the-counter medication and we check it for interactions with Nitric Oxide Booster by SNAP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nitric Oxide Booster by SNAP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “Amino Acid Support Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Nitric Oxide Complex” is a proprietary blend — the label gives one combined amount (1.50 Gram(s)) without saying how much of each component you get.
  • “NITRIC OXIDE BOOST BLEND” is a proprietary blend — the label doesn't break down how much of each component you get.

SNAP's Nitric Oxide Booster contains 11 ingredients, with several designed to boost nitric oxide production. The core actives are three forms of L-arginine (plain L-arginine, L-arginine hydrochloride, and L-arginine alpha-ketoglutarate)—amino acids that your body uses to make nitric oxide, a molecule that relaxes blood vessels.

L-citrulline is another amino acid that converts to L-arginine in your body. Supporting these are L-taurine (an amino acid with cardiovascular roles), L-norvaline, vanadyl sulfate (a mineral compound), Tribulus terrestris fruit extract, Muira Puama extract, and Asian ginseng.

The formula also includes Vitamin B3 and groups labeled as Amino Acid Support Blend, Nitric Oxide Complex, Nitric Oxide Boost Blend, and Stamina Surge Blend. Inactive ingredients are hypromellose (capsule material), water, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Nitric oxide support and blood flow.
  • We looked for evidence on: Erectile dysfunction (ED), Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Hypertension, Cardiovascular disease (CVD) — and 3 related terms.
  • The strongest evidence on file: Panax Ginseng is rated "Possibly Effective" for Erectile dysfunction (ED) (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.

Evidence for most ingredients is limited. L-citrulline shows possibly effective evidence for athletic performance, but insufficient evidence for cardiovascular disease, heart failure, and diabetes.

L-taurine has possibly effective evidence for hepatitis and congestive heart failure, but is possibly ineffective for obesity. Tribulus terrestris is possibly effective for sexual dysfunction but possibly ineffective for athletic performance, with insufficient evidence for benign prostatic hyperplasia.

Asian ginseng is possibly effective for erectile dysfunction, sexual arousal, influenza, and cognitive function, plus multiple sclerosis-related fatigue. Vanadium is likely effective only for vanadium deficiency; effectiveness for athletic performance, cancer, diabetes, and high cholesterol is insufficient.

Muira Puama and the blended ingredients lack established effectiveness ratings in our data.

The evidence, ingredient by ingredient Niacin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is often well tolerated short-term but can lower blood pressure and may not be safe for everyone; use only under medical supervision. Most common side effects are abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

L-citrulline is generally well tolerated in healthy adults, though long-term safety isn't fully studied; most common effects are gastrointestinal discomfort and heartburn. There isn't enough safety data, so avoid L-citrulline during pregnancy and while breastfeeding.

Vanadium is well tolerated at doses below 1.8 mg daily, but higher doses may cause gastrointestinal upset, and long-term high doses can damage kidneys; avoid during pregnancy and breastfeeding. L-taurine is generally well tolerated short-term in healthy adults, though constipation, diarrhea, and indigestion can occur; it's likely safe in pregnancy.

Tribulus terrestris is often well tolerated short-term, but quality and long-term safety data are limited; avoid during pregnancy and breastfeeding due to potential hormone effects and unknown safety. Muira Puama has limited human safety data; avoid during pregnancy and breastfeeding.

Asian ginseng is generally well tolerated for up to 6 months, with insomnia being the most common side effect; avoid during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Niacin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Tribulus, Vanadium, L-arginine, Niacin, Panax Ginseng, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,418 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take: blood pressure medications (including ACE inhibitors and ARBs), blood thinners or antiplatelet drugs, diabetes medications, potassium-sparing water pills, lithium, heart medications (including isoproterenol or sildenafil), midazolam, MAOIs or selegiline, insulin, furosemide, raltegravir, or warfarin. These are all Moderate severity interactions with one or more ingredients in this formula.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed to support nitric oxide production, but it's not for everyone. If you take blood pressure medication, blood thinners, diabetes drugs, lithium, or any heart or psychiatric medication, you need to check with your pharmacist or doctor before starting—these ingredients have documented interactions.

Even without medications, this product carries real risks of low blood pressure and should be used only under medical guidance. Talk to your pharmacist before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nitric Oxide Booster, straight from the product label.

Brand SNAP
Barcode (UPC) 0643530160617
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296737
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nitric Oxide Booster by SNAP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
0643530160617
IngredientAmount% DV
L-Arginine0 NP--
L-Citrulline0 NP--
L-Norvaline0 NP--
Vanadyl Sulfate0 NP--
L-Taurine0 NP--
Vitamin B310 mg NE63%
L-Arginine Hydrochloride0 NP--
Amino Acid Support Blend0 NP--
Tribulus terrestris Fruit Extract0 NP--
Muira Puama extract0 NP--
Asian Ginseng0 NP--
L-Arginine Alpha-Ketoglutarate0 NP--
Nitric Oxide Complex1.5 Gram(s)--
NITRIC OXIDE BOOST BLEND0 NP--
Stamina Surge Blend0 NP--

Other ingredients: Hypromellose, Water, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Powered by natural botanicals Tribulus terrestris + Muira puama bark extract + Panax ginseng root

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 2 capsules with food up 2 times per day or as directed by your medical provider.

Storage

Store away from humidity, heat, and light. Do not refrigerate.

Precautions

If any reactions occur, discontinue use of dietary supplement and consult your doctor.

Warning: Do not exceed daily dosage.

This product should only be taken by healthy individuals at least 18 years of age or older. Keep out of reach of children.

Consult your healthcare provider if you are pregnant or nursing, or have any other medical concerns.

You should not take this product with alcohol.

Formulation

Manufactured in a FDA registered facility Manufactured in a GMP certified facility

Supports quick recovery Healthy circulation Supports muscle growth

Seals/Symbols

Manufactured in USA

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nitric Oxide Booster by SNAP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nitric Oxide Booster label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nitric Oxide Booster by SNAP

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B3

Interacts with
727 drugs
10 mg NE per serving Form: Niacin

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Vitamin B3 monograph & interactions

Nitric Oxide Complex

1.5 Gram(s) per serving
  • › Amino Acid Support Blend
  • › NITRIC OXIDE BOOST BLEND
  • › Stamina Surge Blend

Other (inactive) ingredients: Hypromellose, Water, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nitric Oxide Booster by SNAP Drug Interactions

Want to check YOUR meds against Nitric Oxide Booster?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,417Drugs
1,417 Moderate

Ingredients driving the most interactions

Vitamin B3 727

Individual Drug Interactions

The ingredients in Nitric Oxide Booster interact with 1,417 drugs. Click any drug to see the details.

1 of the 4 ingredients in Nitric Oxide Booster interact with drugs. Each result below shows which ingredient is responsible. Vitamin B3

Each ingredient & the kinds of drugs it affects

For each ingredient in Nitric Oxide Booster with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B315 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Vitamin B3 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nitric Oxide Booster, from the product label.

SNAP

See all SNAP products
Name
SNAP Supplements
Street Address
11012 NE 39th St., Suite C5
City
Vancouver
State
WA
ZipCode
98682
Phone Number
1-888-491-5043
Web Address
snapsupplements.com
Pharmacist Counseling Corner

Nitric Oxide Booster by SNAP: Common Questions

Does Nitric Oxide Booster by SNAP interact with any medications?
Yes. Based on its ingredients, Nitric Oxide Booster has a known interaction with 1,417 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nitric Oxide Booster contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-arginine do?
L-arginine is an amino acid your body uses to produce nitric oxide, which relaxes and widens blood vessels. This can improve blood flow and lower blood pressure in some people. The product contains three different forms of L-arginine to support nitric oxide production.
Is this safe to take during pregnancy?
No, you should avoid this product during pregnancy. L-citrulline, vanadium, Tribulus terrestris, Muira Puama, and Asian ginseng all lack enough safety information for pregnancy. Talk with your doctor before taking any supplement while pregnant.
Can I take this while breastfeeding?
You should avoid this product while breastfeeding. L-citrulline, vanadium, Tribulus terrestris, Muira Puama, and Asian ginseng all lack reliable safety data for nursing. Although L-taurine occurs naturally in breast milk, the safety of supplement doses is not well studied, so caution is advised.
What are the most common side effects?
The main side effects come from L-arginine and L-citrulline: abdominal pain, bloating, nausea, diarrhea, headache, insomnia, flushing, and gastrointestinal discomfort. At higher doses, vanadium can cause stomach upset. L-taurine may cause constipation or diarrhea. Asian ginseng commonly causes insomnia.
Does this product work for athletic performance?
L-citrulline shows possibly effective evidence for athletic performance. The other ingredients lack established effectiveness for this use in our data, though some have insufficient evidence. Talk with your trainer or doctor about whether this product fits your specific goals.
Can I take this with erectile dysfunction medications like Viagra?
No—do not combine this product with sildenafil (Viagra) or other PDE-5 inhibitors without your doctor's approval. L-arginine, L-citrulline, and Tribulus terrestris all interact with these medications and may cause dangerously low blood pressure. Check with your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nitric Oxide Booster label
Go deeper

The Full Monographs Behind Nitric Oxide Booster’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph →
Sources

Sources & How We Checked

Nitric Oxide Booster's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 254 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
  20. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
  22. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
  23. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
  24. Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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