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Dietary supplement

OptiBeet Ingredients & Drug Interactions

by VitaMonk

OptiBeet label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OptiBeet against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OptiBeet is a dietary supplement by VitaMonk with 2 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 861 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet (Beta vulgaris) root extract, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OptiBeet by VitaMonk

Ask about any prescription or over-the-counter medication and we check it for interactions with OptiBeet by VitaMonk — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of OptiBeet by VitaMonk

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

OptiBeet contains 2 active ingredients: L-citrulline, an amino acid that your body converts to another amino acid called L-arginine to support blood vessel function, and beet root extract, a concentrated form of the beetroot vegetable rich in nitrates and betalains (plant pigments). The powder also includes stevia leaf extract as an inactive ingredient for sweetness.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cardiovascular health and exercise performance.
  • We looked for evidence on: Athletic performance, Cardiovascular disease (CVD), Coronary heart disease (CHD), Exercise-induced muscle damage, Exercise-induced muscle soreness, Heart failure — and 4 related terms.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beet is rated "Possibly Effective" for Exercise-induced muscle soreness.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

L-citrulline is possibly effective for athletic performance, but the evidence for heart disease, heart failure, diabetes, and other conditions is either insufficient or possibly ineffective (as with sarcopenia). Beet root extract is possibly effective for athletic performance and exercise-related muscle soreness but possibly ineffective for COPD; evidence for cognitive function and cholesterol is insufficient.

Neither ingredient's benefit for most conditions studied has solid proof behind it.

The evidence, ingredient by ingredient L-citrulline Beet

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety isn't fully established. The most common side effects are stomach discomfort and heartburn.

Beet root extract is well tolerated short-term; as a food, beet is widely eaten, but concentrated supplements lack robust safety data, so caution is warranted. The most common side effect is red (or sometimes black) stools, which is harmless.

Rare serious effects include low blood calcium and kidney damage with large amounts. During pregnancy, there isn't enough safety data, so avoid this product.

Breastfeeding safety is also unknown, so avoid use while nursing.

Side effects, ingredient by ingredient L-citrulline Beet

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Beet, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 862 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking OptiBeet, double-check with your doctor or pharmacist if you take blood pressure medications (both ingredients may lower pressure further) or erectile dysfunction medications like sildenafil (Moderate interaction with L-citrulline). Also flag any medication metabolized by CYP3A4 liver enzymes — beet root extract may slow their clearance (Moderate).

If you take medications broken down by the CYP1A2 enzyme, beet may speed their clearance (Minor). No interactions are documented for stevia.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

OptiBeet may support athletic performance and muscle recovery if you're an athlete, but the evidence isn't ironclad. If you take blood pressure medications, erectile dysfunction drugs, or medications your liver breaks down (which is very common), you need to discuss this product with your doctor or pharmacist before starting — the interactions could change how those drugs work.

Pregnant women and nursing mothers should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OptiBeet, straight from the product label.

Brand VitaMonk
Barcode (UPC) B01MT1FGMN
Net contents 302 Gram(s); 0.66 lb(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 242161
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OptiBeet by VitaMonk, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
30
UPC/BARCODE
B01MT1FGMN
IngredientAmount% DV
L-Citrulline3000 mg--
Beet (Beta vulgaris) root extract7000 mg--

Other ingredients: Stevia leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions & Recommended Use: As a dietary supplement, mix 1 scoop with 10-12 oz of water. Take 1 scoop daily for cardiovascular health or 30-60 mins before exercise to enhance performance.

Precautions

Warning: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18 and individuals with known medical conditions should consult a physician before using this dietary supplement.

Pregnant or nursing mothers, children under 18 and individuals with known medical conditions should consult a physician before using this dietary supplement.

Discontinue use and consult your physician if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice 100% Premium Quality Satisfaction Guaranteed

Formula

Advanced Beetroot formula with citrulline

Formulation

Promotes healthy nitric oxide levels Helps improve exercise endurance

FDA Statement of Identity

Dietary Supplement

General Statements

To get 15% off your next purchase, visit www.vitamonk.com/thanks

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OptiBeet by VitaMonk label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OptiBeet label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OptiBeet by VitaMonk

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
3000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Beet (Beta vulgaris) root extract

Interacts with
861 drugs
7000 mg per serving Form: Nitrate

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet (Beta vulgaris) root extract monograph & interactions

Other (inactive) ingredients: Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

OptiBeet by VitaMonk Drug Interactions

Want to check YOUR meds against OptiBeet?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
861Drugs
786 Moderate 75 Minor

Ingredients driving the most interactions

Beet (Beta vulgaris) root extract 861
L-Citrulline 178

Individual Drug Interactions

The ingredients in OptiBeet interact with 861 drugs. Click any drug to see the details.

2 of the 2 ingredients in OptiBeet interact with drugs. Each result below shows which ingredient is responsible. Beet (Beta vulgaris) root extract L-Citrulline

Each ingredient & the kinds of drugs it affects

For each ingredient in OptiBeet with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet (Beta vulgaris) root extract3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet (Beta vulgaris) root extract full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OptiBeet, from the product label.

VitaMonk

See all VitaMonk products
Name
VitaMonk
Street Address
2637 E Atlantic Blvd #24351
City
Pompano Beach
State
FL
ZipCode
33062
Web Address
VitaMonk.com
Pharmacist Counseling Corner

OptiBeet by VitaMonk: Common Questions

Does OptiBeet by VitaMonk interact with any medications?
Yes. Based on its ingredients, OptiBeet has a known interaction with 861 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OptiBeet contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will OptiBeet actually help my athletic performance?
L-citrulline and beet root extract are both possibly effective for athletic performance based on the evidence we have, but that doesn't mean the effect is guaranteed or dramatic. The evidence isn't strong enough to call it proven, so results may vary from person to person.
What are the most common side effects?
L-citrulline most often causes stomach discomfort or heartburn. Beet root extract commonly causes red or black stools — this is harmless and just a sign your body is processing the pigments in the beet.
Is it safe to take OptiBeet long-term?
L-citrulline is well tolerated in healthy adults, but long-term safety hasn't been fully studied. Beet root as a food is fine, but concentrated supplements lack robust long-term safety data, so use caution with extended use.
Can I take OptiBeet if I'm pregnant or breastfeeding?
No — L-citrulline lacks enough safety data in pregnancy, so it's best to avoid it. Beet root's safety while breastfeeding is also unknown, so avoid supplemental use. Talk with your doctor or pharmacist about what's safe for you.
Why does the search tool show so many medications interacting with OptiBeet?
Beet root extract can inhibit a major liver enzyme (CYP3A4) that breaks down hundreds of different medications. That's why the total interaction count is high — many drugs depend on that enzyme, even though your actual risk depends on which specific medications you take.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OptiBeet label
Go deeper

The Full Monographs Behind OptiBeet’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph →
Sources

Sources & How We Checked

OptiBeet's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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