Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Organic Guduchi Ingredients & Drug Interactions

by Himalaya

Organic Guduchi label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Guduchi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Guduchi is a dietary supplement by Himalaya with 3 active ingredients. Its ingredients are commonly taken for immune support, fever, blood sugar support.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Indian Tinospora powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Guduchi by Himalaya

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Guduchi by Himalaya — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Guduchi by Himalaya

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Organic Guduchi by Himalaya contains three forms of tinospora cordifolia (Indian guduchi): organic powder, organic extract, and organic supercritical CO₂ extract. All three are the active ingredients and deliver the same plant compound in different concentrations and processing methods.

The product has no inactive fillers or binders listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tinospora Cordifolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tinospora Cordifolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

The evidence supports tinospora for diabetes. Clinical research shows it can lower fasting blood sugar and glycated hemoglobin in adults with type 2 diabetes, making it possibly effective for that use.

For allergic rhinitis (hay fever), asthma, athletic performance, cancer, and hepatitis, the evidence we hold is insufficient to rate whether it works.

The evidence, ingredient by ingredient Tinospora Cordifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, tinospora is generally well tolerated, but liver injury is a serious rare side effect that demands attention. In case series, 49 patients developed autoimmune hepatitis, acute hepatitis, worsening of chronic liver disease, or acute liver failure after taking tinospora in various forms for a median of 42–90 days; some cases were fatal or required transplant.

The most common mild side effects reported are headache and nasal pain. Because of the liver injury risk, use should be careful and guided by a healthcare provider.

Safety in pregnancy has not been established, so it's best avoided during pregnancy. There isn't enough reliable information to recommend it while breastfeeding either.

Talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Tinospora Cordifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tinospora Cordifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 612 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Organic Guduchi, check with your doctor or pharmacist if you take any of these: diabetes medications (risk of low blood sugar), immunosuppressants, or any drug metabolized by your liver's CYP2D6, CYP2C19, CYP1A2, or CYP2C9 enzyme systems. The most urgent concern is liver safety—if you have any liver condition or history of liver disease, do not take this without medical clearance.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Himalaya's Organic Guduchi is possibly effective for type 2 diabetes based on clinical evidence, but it carries real risks: liver injury (rare but serious, with fatalities reported), and moderate interactions with over 600 medications through liver enzyme systems. If you have liver disease, take diabetes or immunosuppressant medications, or use any prescription drug processed by your liver, discuss this supplement with your own doctor or pharmacist before starting.

Pregnant or breastfeeding women should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Guduchi, straight from the product label.

Brand Himalaya
Barcode (UPC) 605069406017
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 282982
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Guduchi by Himalaya, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
Servings per container
60
UPC/BARCODE
605069406017
IngredientAmount% DV
organic Indian Tinospora powder450 mg--
organic Indian Tinospora extract200 mg--
organic Indian Tinospora supercritical Co2 extract50 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No wheat, corn, soy, or dairy. No ingredients of animal origin. Gluten free

No ingredients of animal origin. Vegan friendly

cGMP

Certified Organic by Control Union Certifications, CU 867461

Product of India

Activates immune function Promotes cellular defense

Non GMO Project Verified nongmoproject.org

USDA Organic

General Statements

Neutral Code No.: KR/Drugs/DLA AUS-83 Mfg. Lic. No. AUS-83 Questions? Please call 1-800-869-4640 or visit www.himalayausa.com

1 month supply

Our cartons are made from 100% recycled fibers, including 40% post-consumer material. Our glass bottles contain at least 48% recycled content.

Happiness through wellness Crafting traditional medicines based on Ayurveda, a 5,000 year old science that believes the journey back to wholeness begins with nurturing the capacity for joy. Trusting the gifts of nature and the irreplaceable relationship between the plant and its native soil for consistent healing properties. Contributing to the wellness of the earth by teaching our family of farmers to grow native plants sustainably on their land and reduce the demand on the local environment. Building communities by advocating women in farming, protecting fair prices, providing maternal health, sponsoring clinical services and offering school wellness programs. Believing that if wellness is the path to happiness, we must contribute to the wellness of all things. Wellness of people, wellness of the environment, wellness of our communities. Family owned for over 90 years

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Guduchi was named Amrita in the ancient texts of Ayurveda, meaning divine nectar. Ancient texts said it has special power called samanam, meaning it bestowed balance throughout the entire body.

Guduchi was named Amrita in the ancient texts of Ayurveda, meaning divine nectar. It was thought to produce ojas, or immunity and life-force. Its popularity throughout history and today is most likely because the texts said it had a special power called samanam, meaning it bestowed balance throughout the entire body. Featured herb on front: Guduchi (aerial parts)

Suggested/Recommended/Usage/Directions

Recommended Use: Adults take 1 caplet twice daily before meals.

Precautions

Caution: As with any supplement, consult a healthcare practitioner if you are pregnant, nursing, taking medication, have a medical condition or are planning any medical procedure.

Discontinue use and consult a healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Brand IP Statement(s)

Himalaya Since 1930

Seals/Symbols

Non GMO Project Verified nongmoproject.org USDA Organic

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Guduchi by Himalaya label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Guduchi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Guduchi by Himalaya

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Indian Tinospora powder

Interacts with
612 drugs
450 mg per serving Form: Bitters

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Ea...

Organic Indian Tinospora powder monograph & interactions

Organic Indian Tinospora extract

Interacts with
612 drugs
200 mg per serving Form: Bitters

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Ea...

Organic Indian Tinospora extract monograph & interactions

Organic Indian Tinospora supercritical Co2 extract

Interacts with
612 drugs
50 mg per serving Form: Bitters

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Ea...

Organic Indian Tinospora supercritical Co2 extract monograph & interactions
Interaction report

Organic Guduchi by Himalaya Drug Interactions

Want to check YOUR meds against Organic Guduchi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
612Drugs
612 Moderate

Ingredients driving the most interactions

organic Indian Tinospora powder 612

Individual Drug Interactions

The ingredients in Organic Guduchi interact with 612 drugs. Click any drug to see the details.

1 of the 3 ingredients in Organic Guduchi interact with drugs. Each result below shows which ingredient is responsible. organic Indian Tinospora powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Guduchi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Indian Tinospora powder6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D
organic Indian Tinospora powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Guduchi, from the product label.

Himalaya

See all Himalaya products
Name
Himalaya Wellness USA Ltd.
Street Address
1101 Gillingham Lane
City
Sugar Land
State
Texas
ZipCode
77478
Phone Number
1-800-869-4640
Web Address
www.himalayausa.com
Pharmacist Counseling Corner

Organic Guduchi by Himalaya: Common Questions

Does Organic Guduchi by Himalaya interact with any medications?
Yes. Based on its ingredients, Organic Guduchi has a known interaction with 612 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Guduchi contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is tinospora (guduchi)?
Tinospora cordifolia, called guduchi in Ayurvedic medicine, is a plant traditionally used in India. This product delivers it in three forms: powder, extract, and supercritical CO₂ extract—all from the same plant, just processed differently.
Does it actually help with blood sugar?
Clinical research shows tinospora can reduce fasting blood glucose and glycated hemoglobin in adults with type 2 diabetes, so it's rated possibly effective for that use. The evidence for other conditions listed—hay fever, asthma, athletic performance, cancer, and hepatitis—is insufficient.
I'm pregnant. Can I take this?
No. Safety hasn't been established in pregnancy, so it's best avoided. Talk with your doctor about alternatives.
What are the side effects?
When taken by mouth, tinospora is generally well tolerated. The most common side effects reported are headache and nasal pain. Rarely, liver injury has been reported, including serious cases of hepatitis and liver failure—so careful use under medical guidance is important.
Why are there so many drug interactions?
Tinospora slows down several liver enzyme systems (CYP2D6, CYP2C19, CYP1A2, CYP2C9) that break down hundreds of medications. When those enzymes work slower, drug levels can build up higher in your body, making them stronger or riskier. That's why checking your exact medications is essential.
Is it safe if I don't take any other medications?
Even without other medications, the main safety concern is liver injury. The product should be used carefully and under guidance; if you have liver disease or a history of liver problems, check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Guduchi is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Guduchi label
Go deeper

The Full Monographs Behind Organic Guduchi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tinospora Cordifolia

Interacts with 612 drugs

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...

Read the full Tinospora Cordifolia monograph →
Sources

Sources & How We Checked

Organic Guduchi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tinospora Cordifolia 16 references
  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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