Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

PreBio Ingredients & Drug Interactions

by Wholly Liquid

PreBio label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PreBio against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PreBio is a dietary supplement by Wholly Liquid with 7 active ingredients. Its ingredients are commonly taken for digestive and gut health, source of soluble fiber, constipation or bowel regularity.Based on those ingredients, 2,146 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acacia Gum, Flax seed powder, Dandelion Leaf Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PreBio by Wholly Liquid

Ask about any prescription or over-the-counter medication and we check it for interactions with PreBio by Wholly Liquid — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PreBio by Wholly Liquid

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.

PreBio contains 7 ingredients, including a proprietary blend with acacia gum (a soluble fiber), fructooligosaccharides (prebiotic carbohydrates), flaxseed powder, chicory root powder, green banana flour, Jerusalem artichoke root extract, and dandelion leaf powder. These are formulated as inactive ingredients including microcrystalline cellulose, hypromellose (a thickener), and water.

The active components work as prebiotic fibers and plant extracts intended to support gut health.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: prebiotic fiber for digestive and gut health.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 3 related terms.
  • The strongest evidence on file: Flaxseed is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Banana is rated "Possibly Effective" for Diarrhea.
  • Also on file: Chicory is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia.

The evidence for PreBio's individual ingredients is mixed. Flaxseed is rated possibly effective for high cholesterol, blood sugar control, breast pain, high blood pressure, and constipation.

Green banana flour is possibly effective for diarrhea. For the other active ingredients—acacia gum, fructooligosaccharides, chicory, and dandelion—the data we hold shows insufficient evidence to rate their effectiveness for the conditions they're traditionally used for, including metabolic syndrome, kidney function, weight loss, bone health, blood sugar, cholesterol, and digestive complaints.

The evidence, ingredient by ingredient Gum Arabic Fructo-oligosaccharides (fos) Flaxseed Chicory Banana Dandelion

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acacia gum and fructooligosaccharides are generally well tolerated but commonly cause gas, bloating, and mild digestive upset, especially at higher doses. Flaxseed is usually well tolerated as a food but can cause bloating, diarrhea, and gastrointestinal complaints; rare severe allergic reactions including anaphylaxis have been reported.

Green banana flour is safe in food amounts, though it may cause bloating, cramping, and gas. Dandelion and chicory are generally well tolerated but may trigger allergic reactions in people sensitive to ragweed and related plants; dandelion pollen can cause allergic rhinitis.

Chicory root is listed as possibly unsafe in pregnancy due to traditional concerns about uterine stimulation; flaxseed is also rated possibly unsafe in pregnancy. For breastfeeding, limited safety data exists for supplement doses of acacia gum, flaxseed, chicory, and dandelion—talk with your doctor or pharmacist before use.

Bananas (green banana flour) and dandelion as foods are considered safe while breastfeeding.

Side effects, ingredient by ingredient Gum Arabic Fructo-oligosaccharides (fos) Flaxseed Chicory Banana Dandelion

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Chicory, Gum Arabic, Dandelion, Flaxseed, Banana.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 2,147 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PreBio, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants or antiplatelet drugs), blood pressure medications, diabetes drugs, antibiotics (especially fluoroquinolones like ciprofloxacin or amoxicillin), potassium-sparing diuretics, lithium, or any drugs your liver metabolizes through CYP1A2 or glucuronidation pathways. Dandelion may lower fluoroquinolone levels and increase lithium; flaxseed and acacia gum affect absorption of several antibiotics and oral drugs generally.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PreBio is a prebiotic supplement intended to support digestive health through fiber and plant extracts, but it carries multiple Moderate-severity interactions with common medications including blood thinners, blood pressure drugs, diabetes medications, and certain antibiotics. If you take any prescription medications—especially for heart, kidney, mood, blood sugar, or infection—check your exact drugs with your pharmacist or doctor before starting this product.

Digestive side effects like gas and bloating are common. Pregnant or breastfeeding people should discuss this supplement with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PreBio, straight from the product label.

Brand Wholly Liquid
Barcode (UPC) WLPB1090
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 272114
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PreBio by Wholly Liquid, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
WLPB1090
IngredientAmount% DV
Proprietary Blend400 mg--
Acacia Gum0 NP--
Fructooligosaccharide0 NP--
Flax seed powder0 NP--
Chicory root powder0 NP--
Green Banana Flour0 NP--
Jerusalem Artichoke Root Extract0 NP--
Dandelion Leaf Powder0 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule per day or as directed by your healthcare professional.

Storage

Storage Instructions: Store at room temperature away from direct sunlight. Keep tightly closed. For longer shelf life, refrigerate after opening.

Precautions

Warning: Consult your healthcare professional before use if you are pregnant, nursing, taking medications, have a known medical condition, or for any use by minors.

Warning: Consult your healthcare professional before use if you are pregnant, nursing, taking medications, have a known medical condition, or for any use by minors.

Do not use if safety seal is broken or missing.

Keep out of reach of children.

For nutritional use only.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Made in USA

Promotes growth of beneficial bacteria

Soy free Dairy free Sugar free Gluten free

Vegan

Allergen free Non-GMO No artificial colors or sugars No synthetic fillers or binders

Brand IP Statement(s)

Supplements as good as food

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PreBio by Wholly Liquid label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PreBio label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PreBio by Wholly Liquid

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

400 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

PreBio by Wholly Liquid Drug Interactions

Want to check YOUR meds against PreBio?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,146Drugs
2,146 Moderate

Ingredients driving the most interactions

Acacia Gum 2,022
Flax seed powder 597
Dandelion Leaf Powder 457
Chicory root powder 86
Green Banana Flour 5

Individual Drug Interactions

The ingredients in PreBio interact with 2,146 drugs. Click any drug to see the details.

5 of the 7 ingredients in PreBio interact with drugs. Each result below shows which ingredient is responsible. Acacia Gum Flax seed powder Dandelion Leaf Powder Chicory root powder Green Banana Flour

Each ingredient & the kinds of drugs it affects

For each ingredient in PreBio with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Acacia Gum2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Acacia Gum full monograph & interactions

Flax seed powder5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
Flax seed powder full monograph & interactions

Dandelion Leaf Powder7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion Leaf Powder full monograph & interactions

Chicory root powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory root powder full monograph & interactions

Green Banana Flour1 drug type · 5 drugs

Levodopa

Taking banana may reduce the effectiveness of levodopa.
A case report describes apparent wearing off in a patient with Parkinson disease after eating a banana every day. The wearing off subsided after removing dietary bananas.

Likelihood Possible Evidence D
Green Banana Flour full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PreBio, from the product label.

Wholly Liquid

See all Wholly Liquid products
Name
Wholly Liquid Nutritional Supplements, LLC
City
Hampton
State
NH
ZipCode
03842
Web Address
www.whollyliquid.com
Pharmacist Counseling Corner

PreBio by Wholly Liquid: Common Questions

Does PreBio by Wholly Liquid interact with any medications?
Yes. Based on its ingredients, PreBio has a known interaction with 2,146 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PreBio contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion or constipation?
Flaxseed and green banana flour are rated possibly effective for constipation and diarrhea respectively. For the other fibers in PreBio—acacia gum, fructooligosaccharides, and chicory—we don't have strong evidence yet. That said, all of these ingredients are high in fiber, which can affect your bowel habits.
What side effects should I watch for?
Gas, bloating, and mild diarrhea are very common, especially when you start or take higher doses. These usually improve within a couple of weeks. Rare severe allergic reactions (anaphylaxis) have been reported with flaxseed and dandelion in people with plant allergies, particularly sensitivity to ragweed and related plants.
Is it safe to take while pregnant?
Flaxseed is rated possibly unsafe in pregnancy, and chicory is also listed as possibly unsafe. Green banana flour and acacia gum as foods are considered safe in pregnancy, but supplement doses haven't been well studied. Talk with your doctor or pharmacist for personalized advice before using this product during pregnancy.
Can I take this while breastfeeding?
Green banana flour and dandelion as foods are considered safe while breastfeeding. However, there isn't enough reliable safety data on supplement-strength doses of acacia gum, flaxseed, chicory, or dandelion while breastfeeding. Check with your doctor or pharmacist to decide what's right for you.
Should I take this at a specific time or away from medications?
Yes. If you take amoxicillin, separate it from this product by at least 2 hours, since acacia gum can reduce its absorption. More generally, because several ingredients may affect how your body absorbs or processes medications, space out doses of this supplement and your prescription drugs by at least 2 hours if possible, and discuss timing with your pharmacist.
What are these ingredients supposed to do?
PreBio is formulated as a prebiotic supplement—the fibers and plant compounds are meant to feed beneficial bacteria in your gut and support digestive health. Acacia gum, fructooligosaccharides, chicory root, and Jerusalem artichoke root are all fermented by your gut flora, while flaxseed, green banana flour, and dandelion are included for their traditional digestive support roles.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PreBio label
Go deeper

The Full Monographs Behind PreBio’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gum Arabic

Interacts with 2,022 drugs

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...

Read the full Gum Arabic monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph → Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph → Herb & supplement monograph

Banana

Interacts with 5 drugs

Bananas are a nutritious, widely eaten fruit that provide potassium, fiber, vitamin B6, and quick energy, and they are part of a healthy diet. While some traditional uses (like easing diarrh...

Read the full Banana monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph →
Sources

Sources & How We Checked

PreBio's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 102 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gum Arabic 8 references
  1. Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
  2. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
  3. Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
  4. Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
  5. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
  6. Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
  7. Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
  8. Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed

See these in context on the Gum Arabic monograph →

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Flaxseed 37 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Thompson LU, Rickard SE, Cheung F, et al. Variability in anticancer lignan levels in flaxseed. Nutr Cancer 1997;27:26-30. PubMed
  4. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  5. Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
  6. Clark WF, Parbtani A, Huff MW, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475-80. PubMed
  7. Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. PubMed
  8. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  9. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  10. Clark WF, Kortas C, Heidenheim P, et al. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr 2001;20:143-8. PubMed
  11. Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991;60:135-42. PubMed
  12. Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 2000;161:47-55. PubMed
  13. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
  14. Adlercreutz H, Fotsis T, Bannwart C, et al. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 1986;25:791-7.. PubMed
  15. Rose DP. Dietary fiber and breast cancer. Nutr Cancer 1990;13:1-8.. PubMed
  16. Lemay A, Dodin S, Kadri N, et al. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 2002;100:495-504.. DOI
  17. Brooks JD, Ward WE, Lewis JE, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr 2004;79:318-25.. PubMed
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Banana 11 references
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Dandelion 27 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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