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Dietary supplement

Premier HCL Ingredients & Drug Interactions

by Premier Research Labs

Premier HCL label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premier HCL against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Premier HCL is a dietary supplement by Premier Research Labs with 1 active ingredient. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Premier HCL by Premier Research Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Premier HCL by Premier Research Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Premier HCL by Premier Research Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Premier HCL is a single-ingredient product: betaine hydrochloride, a compound that provides hydrochloric acid to the stomach. The capsule itself is plant-based.

Betaine hydrochloride is marketed to support stomach acid levels, which some believe aids digestion.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Betaine Hydrochloride's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: assist stomach acids in digestion and nutrient absorption.
  • We looked for evidence on: Dyspepsia, hypochlorhydria, indigestion, malabsorption.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence isn't established in our data for any of the conditions this product is used for — indigestion (dyspepsia), low thyroid hormone levels (hypothyroidism), diarrhea, rheumatoid arthritis, food allergies, or hay fever (allergic rhinitis). All carry a rating of insufficient reliable evidence, meaning we don't have enough solid research to say whether it works for these purposes.

The evidence, ingredient by ingredient Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride may irritate your stomach and is not safe if you have ulcers, gastritis, or true acid reflux — it'll only make those worse and could slow ulcer healing or cause heartburn. There isn't enough safety data to recommend it during pregnancy, so it's best avoided then.

Safety during breastfeeding hasn't been studied, so avoid use while nursing as well.

Side effects, ingredient by ingredient Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers, antacids, or proton pump inhibitors (PPIs) for acid reflux or heartburn, double-check with your doctor or pharmacist before using Premier HCL. Betaine hydrochloride increases stomach acid, which could reduce how well these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Premier HCL is a single-ingredient supplement for people interested in boosting stomach acid. It's not suitable if you have ulcers, gastritis, or acid reflux, and you'll want to skip it in pregnancy and while breastfeeding.

If you take any medication that reduces stomach acid — antacids, H2-blockers, or PPIs — check with your doctor or pharmacist before starting, because this product could interfere with how those drugs work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premier HCL, straight from the product label.

Brand Premier Research Labs
Barcode (UPC) 807735021771
Net contents 90 Plant-Source Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269260
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premier HCL by Premier Research Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
807735021771
IngredientAmount% DV
Betaine Hydrochloride500 mg--

Other ingredients: Plant-Source Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule after each meal, 3 times daily, especially cooked meals or as directed by a health professional.

Formula

This product features betaine hydrochloride which assists the body's natural stomach acids in the digestion and absorption of nutrients, especially protein, vitamin B-12, calcium, iron and other minerals.

Betaine Hydrochloride

Kosher certified

OU Kosher we are proud to offer many OU Kosher Certified products.

Precautions

Tamper Seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant/nursing, taking medications or have a medical condition, before taking this or any other product.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Premier digestive support

Non GMO Project Verified nongmoproject.org

PRL's quality guarantee Purity verified No chemical or radiation sterilization Pathogen microbiology performed Heavy metal tested FDA-monitored cGMP facility

Pure vegan

Gluten free No added magnesium stearate

As we age, we typically produce less hydrochloric acid (HCL) which reduces our ability to efficiently absorb nutrients from food. Reduced HCL production affects the amount of protein and calcium we can absorb and can interfere with bone metabolism. Incomplete protein metabolism can imbalance intestinal flora. Taking betaine hydrochloride helps promote absorption of nutrients.

Manufactured in a cGMP compliant facility for superior quality assurance

Seals/Symbols

Non GMO Project Verified nongmoproject.org

OU Kosher we are proud to offer many OU Kosher Certified products.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premier HCL by Premier Research Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premier HCL label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premier HCL by Premier Research Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Betaine Hydrochloride

Interacts with
36 drugs
500 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Other (inactive) ingredients: Plant-Source Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premier HCL by Premier Research Labs Drug Interactions

Want to check YOUR meds against Premier HCL?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Premier HCL interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Premier HCL interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Premier HCL with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premier HCL, from the product label.

Premier Research Labs

See all Premier Research Labs products
Name
Premier Research Labs
Pharmacist Counseling Corner

Premier HCL by Premier Research Labs: Common Questions

Does Premier HCL by Premier Research Labs interact with any medications?
Yes. Based on its ingredients, Premier HCL has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premier HCL contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Who shouldn't take Premier HCL?
Avoid it if you have ulcers, gastritis, or true acid reflux — betaine hydrochloride will increase stomach acid and could make those conditions worse. Also skip it if you're pregnant or breastfeeding, since there isn't enough safety data. If you take any medication that lowers stomach acid, talk to your doctor or pharmacist first.
Does Premier HCL actually help with digestion?
The evidence in our data isn't established for any of the uses it's marketed for — including indigestion, diarrhea, and food sensitivities. There simply aren't enough solid studies to say whether it works.
What are the side effects?
Betaine hydrochloride may irritate your stomach and cause heartburn. Theoretically, it could also worsen or slow healing of stomach or small-intestine ulcers.
Can I take this with antacids or heartburn medication?
Not without checking first. Betaine hydrochloride raises stomach acid while antacids, H2-blockers, and PPIs work to lower it — taking them together could make your heartburn medication less effective. Check with your doctor or pharmacist before combining them.
What exactly is betaine hydrochloride?
It's a compound that provides hydrochloric acid — the acid naturally found in your stomach. This product is designed to increase stomach acid levels.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premier HCL is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premier HCL label
Go deeper

The Full Monographs Behind Premier HCL’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Premier HCL's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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