Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Probiotic Powder Ingredients & Drug Interactions

by Treehouse

Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Probiotic Powder is a dietary supplement by Treehouse with 7 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum, Lactobacillus acidophilus, Bifidobacterium breve. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Probiotic Powder by Treehouse

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Proprietary Synergistic Blend” is a proprietary blend — the label gives one combined amount (3,000,000,000 Unit(s)) without saying how much of each component you get.

This powder contains 7 active ingredients—all live bacterial cultures meant to support your gut health. The main strains are Bifidobacterium bifidum, Lactobacillus acidophilus, Bifidobacterium infantis, Bifidobacterium breve, Lactobacillus rhamnosus, Lactobacillus fermentum, and Lactobacillus casei, grouped in what the label calls a proprietary synergistic blend.

The inactive ingredients are maltodextrin, silica, and ascorbic acid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and immune support for kids.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence varies by strain. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum and Lactobacillus acidophilus are both possibly effective for IBS and respiratory tract infections. For other uses listed on the label—like hay fever, anxiety, and cognitive decline—the evidence we hold is either insufficient to rate or suggests the ingredient may not be effective.

For Lactobacillus rhamnosus, Lactobacillus fermentum, Lactobacillus casei, and Bifidobacterium infantis, effectiveness ratings are not in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy people. That said, those with weakened immune systems should be cautious, and you should check with your doctor before starting, especially if you're critically ill.

Bloating and flatulence are reported with probiotic use in general, though not specifically linked to all strains here. In rare cases, live probiotics have caused serious infections like sepsis in critically ill patients, but these are uncommon.

One case of vomiting and fever was reported in a child taking B. bifidum and L. acidophilus together, though it's unclear if the probiotics caused it.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Breve, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main thing to watch for is antibiotic drugs. If you take any antibiotics, separate them from this probiotic powder—take one, then wait several hours before taking the other—so the antibiotic doesn't kill off the beneficial bacteria.

Your doctor or pharmacist can help you time them properly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Treehouse Probiotic Powder may help with IBS and some digestive issues if you choose a strain supported by evidence, but talk with your doctor first—especially if you have a weakened immune system, are very ill, or take antibiotics regularly. The key thing to know is spacing: if you're on antibiotics, don't take them at the same time as this powder.

Check in with your doctor or pharmacist before starting to make sure it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Powder, straight from the product label.

Brand Treehouse
Barcode (UPC) 068958023854
Net contents 2 oz.; 60 Gram(s)
Market status On market
Date entered into DSLD Oct 27, 2014
DSLD ID 38837
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children (All), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Powder by Treehouse, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 tsp
Maximum serving Sizes:
1 tsp
UPC/BARCODE
068958023854
IngredientAmount% DV
Bifidobacterium bifidum450000000 Unit(s)--
Lactobacillus rhamnosus1050000000 {Unit(s)}--
Lactobacillus fermentum150000000 {Unit(s)}--
Lactobacillus acidophilus300000000 {Unit(s)}--
Bifidobacterium infantis300000000 {Unit(s)}--
Bifidobacterium breve450000000 {Unit(s)}--
Proprietary Synergistic Blend3000000000 {Unit(s)}--
Lactobacillus casei300000000 {Unit(s)}--

Other ingredients: Maltodextrin, Silica, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Concentration Per Gram on Expiration Date: 3 Billion Live Micro-organisms

Recyclable container and label.

Contributes to a natural healthy intestinal flora*

Formula

Specifically formulated for kids, Probiotic powder contains a proprietary blend of only the most potent bacteria strains that work synergistically to guarantee maximum activity.*

Kids Supplements

Contains milk and soy.

Brand IP Statement(s)

Treehouse Kids Supplements are manufactured by Natural Factors(TM) to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Treehouse logo(TM) is a trademark of the Corus(TM) Entertainment group of companies. All rights reserved. Max & Ruby (C) Rosemary Wells Licensed by Nelvana Limited. NELVANA is a registered trademark of Nelvana Limited. CORUS is a trademark of Corus Entertainment Inc. All rights reserved.

Treehouse(TM) Kids Supplements

Max & Ruby

Formulation

Contains no artificial preservatives, color or sweeteners; no gluten or wheat.

Precautions

Sealed for your protection. Do not use if seal is broken.

Contains milk and soy.

Keep out of reach of children.

Storage

For freshness, store in a cool, dry place.

FOR MAXIMUM POTENCY, REFRIGERATE.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Treehouse(TM)

Max & Ruby(TM)

NELVANA(TM) A Corus(TM) Entertainment Inc. Company

FDA Statement of Identity

DIETARY SUPPLEMENT

General

R0

Suggested/Recommended/Usage/Directions

Suggested Usage: Children 0–5 years old: 1/2 teaspoon, 1–3 times per day. Children 6–12 years old: 1/2 –1 teaspoon, 3 times a day. Take on a full stomach or as directed by a health professional. Mix into juices, protein drinks or sprinkle on cereal or fruit.

See for yourself

Probiotic Powder by Treehouse label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Probiotic Powder by Treehouse

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 tsp Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Synergistic Blend

3000000000 {Unit(s)} per serving

Other (inactive) ingredients: Maltodextrin, Silica, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Powder by Treehouse Drug Interactions

Want to check YOUR meds against Probiotic Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Powder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Probiotic Powder, from the product label.

Treehouse

See all Treehouse products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Probiotic Powder by Treehouse: Common Questions

Does Probiotic Powder by Treehouse interact with any medications?
Yes. Based on its ingredients, Probiotic Powder has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Powder contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this probiotic actually work for IBS or diarrhea?
Lactobacillus acidophilus is possibly effective for IBS, antibiotic-associated diarrhea, and a couple of other digestive issues based on the evidence we have. Bifidobacterium bifidum is possibly effective for IBS and respiratory infections. For some other conditions listed, the evidence is too limited to say either way, and for a few uses, the data suggests they may not help. Talk to your doctor about whether this is a good fit for what you're dealing with.
Is it safe to take while I'm pregnant or breastfeeding?
Both Bifidobacterium bifidum and Lactobacillus acidophilus are rated possibly safe in pregnancy. For the other strains in this product—Lactobacillus rhamnosus, Lactobacillus fermentum, Lactobacillus casei, and Bifidobacterium infantis, Bifidobacterium breve—we don't have pregnancy or breastfeeding safety data on file. Reach out to your doctor or midwife before taking this while pregnant or nursing so you can get personalized advice.
What are the side effects?
Bloating and flatulence are reported with probiotics in general. Taking L. acidophilus with other probiotics may cause occasional gastrointestinal discomfort like abdominal pain, diarrhea, or burping, though these are uncommon. One clinical trial with a multi-strain blend reported a couple of rashes and itching in some participants, though it's not clear those were due to the probiotics themselves.
Can I take this if I have a weak immune system?
Those with weakened immune systems should be cautious with live probiotics like these. In rare cases, critically ill patients have developed serious infections from probiotic bacteria. Check with your doctor before starting this product—they know your specific situation and can tell you if it's right for you.
What happens if I take it at the same time as my antibiotic?
The antibiotic may kill a lot of the live probiotic bacteria, so the probiotic won't work as well. Instead, space them out—take one, wait several hours, then take the other. Your pharmacist can help you figure out the best timing for your specific medications.
How many active ingredients are in here?
Seven—a mix of Bifidobacterium and Lactobacillus strains grouped in a proprietary blend. The label groups them together rather than listing exact amounts for each strain separately.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Powder label
Sources

Sources & How We Checked

Probiotic Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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