Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Propolis Liquid Extract Ingredients & Drug Interactions

by CATALO

Propolis Liquid Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Propolis Liquid Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Propolis Liquid Extract is a dietary supplement by CATALO with 1 active ingredient. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 923 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Propolis Extract, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Propolis Liquid Extract by CATALO

Ask about any prescription or over-the-counter medication and we check it for interactions with Propolis Liquid Extract by CATALO — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Propolis Liquid Extract by CATALO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: propolis extract, a resinous mixture that honeybees collect and use in their hives. Propolis is the sole component delivering the supplement's claimed benefits.

The only other ingredient listed is propylene glycol, a common liquid filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: liver and lung health, throat and oral health.
  • We looked for evidence on: Burns, Canker sores, Dental caries, Denture stomatitis, Gingivitis, Herpes labialis (cold sores) — and 4 related terms.
  • The strongest evidence on file: Propolis is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Propolis is rated "Possibly Effective" for Oral mucositis.
  • Also on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Burns, Nonalcoholic fatty liver disease (NAFLD), Dental caries, Gingivitis, and more.

Propolis shows possibly effective evidence for oral mucositis (mouth inflammation or ulceration) and herpes labialis (cold sores). For diabetes, the evidence is also rated possibly effective.

For dengue fever, the data we hold is insufficient to establish a rating. This means the research so far suggests a potential benefit for the first three uses, but more high-quality studies are still needed to confirm it works reliably.

The evidence, ingredient by ingredient Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Propolis is generally well tolerated when taken by mouth or applied to skin over the short term. The most commonly reported side effect in trials is mild headache—around 7% of people taking 250 mg twice daily for 4 months experienced it.

When applied topically, some people develop contact dermatitis (skin irritation) or cheilitis (lip inflammation). Serious allergic reactions are rare overall but possible, especially in people sensitive to bee products.

Propolis is not recommended during pregnancy—there isn't enough safety data to know whether it's safe. While breastfeeding, the data suggests it may be possibly safe, but again, reliable information is limited.

If you're pregnant or breastfeeding, talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propolis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 924 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—propolis may increase bleeding risk or reduce warfarin's effectiveness. Additionally, tell them about any medications processed by your liver, including many heart drugs, antidepressants, and pain relievers, since propolis theoretically could raise their blood levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Propolis may help with cold sores, mouth inflammation, and diabetes management if the research holds up for your situation. The main thing to watch is potential interactions with medications your liver processes, especially blood thinners.

If you take any prescription drugs—particularly warfarin or antiplatelet agents—or if you have a bee allergy, check your full medication list with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Propolis Liquid Extract, straight from the product label.

Brand CATALO
Net contents 25 Milliliter(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303131
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Propolis Liquid Extract by CATALO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
50
IngredientAmount% DV
Propolis Extract, Natural200 mg--

Other ingredients: Propylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Propolis is produced by honeybees and has natural antibiotic properties, which has a long history of traditional use for liver and lung health. This product is made from premium quality Australian bee propolis by an advanced technology and it is free from alcohol and hormones.

Propolis Liquid Extract 40% concentration

Formulation

This product is made from premium quality Australian bee propolis by an advanced technology and it is free from alcohol and hormones.

It can be used for protecting against oral problems, easing allergic symptoms, burns, sore throat, nasal congestion & coughs symptoms.

Suitable for: Sore throat, oral problem, enhance liver function, long working hours, frequent smokes and drinkers, stressful lifestyle, frequent travelers, want to ease allergic symptoms, easily get sick

100% alcohol free

This product may contain black precipitates. This is a normal phenomenon and does not affect product quality.

Made in Australia

Extra Strength

General Statements

Scan and discover more about this product!

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Serving directions For adults, take 10 drops (0.5mL) 1-3 times daily. Take directly or add to water. External use: Suitable for cuts or scratches, insect bites and stings, acne and minor skin infections, swab affected area 1-3 times daily

Storage

Storage Keep in a dry and cool place. Avoid direct sunlight

Precautions

Consult your healthcare practitioner before use for children under 2 years.

Propolis may cause skin irritation or allergic reactions. Test before use. If irritation or swelling of the mouth or throat occurs, discontinue use.

Seals/Symbols

cGMP Current Good Manufacturing Practices

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Propolis Liquid Extract by CATALO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Propolis Liquid Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Propolis Liquid Extract by CATALO

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container50 Amounts shown are per serving.

Propolis Extract, Natural

Interacts with
923 drugs
200 mg per serving

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Propolis Extract, Natural monograph & interactions

Other (inactive) ingredients: Propylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Propolis Liquid Extract by CATALO Drug Interactions

Want to check YOUR meds against Propolis Liquid Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
923Drugs
923 Moderate

Ingredients driving the most interactions

Propolis Extract, Natural 923

Individual Drug Interactions

The ingredients in Propolis Liquid Extract interact with 923 drugs. Click any drug to see the details.

1 of the 1 ingredient in Propolis Liquid Extract interact with drugs. Each result below shows which ingredient is responsible. Propolis Extract, Natural

Each ingredient & the kinds of drugs it affects

For each ingredient in Propolis Liquid Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Propolis Extract, Natural8 drug types · 923 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
Propolis Extract, Natural full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Propolis Liquid Extract, from the product label.

CATALO

See all CATALO products
Name
CATALO Natural Health USA Inc.
City
City of Industry
State
CA
ZipCode
91748
Web Address
CATALO.com
Pharmacist Counseling Corner

Propolis Liquid Extract by CATALO: Common Questions

Does Propolis Liquid Extract by CATALO interact with any medications?
Yes. Based on its ingredients, Propolis Liquid Extract has a known interaction with 923 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Propolis Liquid Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is propolis?
Propolis is a resinous mixture honeybees collect and use to seal their hives. It's made of plant resins, waxes, and other compounds, and it's been used in traditional medicine for centuries. This product is a liquid extract of that raw material.
Will it help my cold sores or mouth sores?
Research suggests propolis is possibly effective for both herpes cold sores and oral mucositis (mouth inflammation or ulceration). That said, 'possibly effective' means the evidence shows promise but isn't yet definitive—results vary by person. Your own doctor or pharmacist can help you weigh whether it's worth trying alongside any other treatments.
What are the most common side effects?
When taken by mouth, mild headache is the most common side effect and occurred in about 7% of people in a trial taking it for 4 months. When applied to skin, some people develop contact dermatitis or lip irritation. Serious allergic reactions are rare but possible, particularly if you're sensitive to bee products.
Is it safe if I'm allergic to bees?
No—people with bee allergies are more likely to have allergic reactions to propolis. If you've had any allergic response to bee stings, honey, or other bee products, avoid this supplement or check with your doctor or pharmacist first.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to know for certain either way. During pregnancy, the evidence suggests it's best avoided. While breastfeeding, it may possibly be safe, but reliable information is limited. Talk with your doctor or pharmacist for personalized guidance if you're in either situation.
Does propolis interact with diabetes medications?
We don't hold specific interaction data for diabetes drugs in our monograph. However, propolis is rated possibly effective for diabetes itself, so combining it with diabetes medication is something to discuss with your doctor or pharmacist before starting—they can help you monitor your blood sugar levels appropriately.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Propolis Liquid Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Propolis Liquid Extract label
Go deeper

The Full Monographs Behind Propolis Liquid Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Propolis

Interacts with 923 drugs

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...

Read the full Propolis monograph →
Sources

Sources & How We Checked

Propolis Liquid Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team