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Dietary supplement

Pure Glutamine Ingredients & Drug Interactions

by IMSOALPHA

Pure Glutamine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Glutamine is a dietary supplement by IMSOALPHA with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Glutamine by IMSOALPHA

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Glutamine by IMSOALPHA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Glutamine by IMSOALPHA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Glutamine is a single-ingredient powder containing L-glutamine, an amino acid your body naturally makes and uses for muscle support, immune function, and intestinal health. There are no inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support muscle recovery and immune function.
  • We looked for evidence on: Exercise-induced muscle damage, Postoperative recovery, Wound healing, Oral mucositis, Chemotherapy-induced diarrhea, Athletic performance — and 2 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Oral mucositis, Wound healing, Exercise-induced muscle damage.

L-glutamine is rated Effective for sickle cell disease. It's rated Possibly Effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

The evidence supporting those uses is still being built, so results may vary.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, L-glutamine is generally well tolerated in healthy adults. The most common side effects are gastrointestinal — belching, bloating, flatulence, constipation, diarrhea, nausea, vomiting, and stomach pain — especially at higher doses (10-30 grams daily).

Headache and musculoskeletal pain have also been reported. A few rare cases of dizziness, mania, and hypomania have been noted, mostly in people with bipolar disorder.

People with kidney or liver disease should take glutamine only under medical supervision. There isn't enough safety data to recommend supplemental doses during breastfeeding without your doctor's input.

Pregnancy appears likely safe based on available data, but talk with your healthcare provider before starting it.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your seizure medications (anticonvulsants) with your doctor or pharmacist before starting this product. The interaction is Moderate severity and based on theory rather than reported cases in people, but it matters enough to clear first.

No other medication types are documented to interact with L-glutamine in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease and certain types of muscle or immune challenges after surgery or serious illness. If you take seizure medications, check with your doctor or pharmacist first — the interaction is theoretical but worth confirming.

Digestive upset is common, especially at higher doses. Chat with your own doctor or pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Glutamine, straight from the product label.

Brand IMSOALPHA
Barcode (UPC) 728028355031
Net contents 500 Gram(s); 17.64 Ounce(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217325
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Glutamine by IMSOALPHA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
100
UPC/BARCODE
728028355031
IngredientAmount% DV
L-Glutamine5000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Support muscle tissue recovery from exercise Supports recovery time Supports normal immune function Laboratory tested for quality & purity Micronized for fast absorption

No filters, sodium or sugar

It has no filters or additives and is micronized for easy mixing.

Lab tested, clinically proven & micronized

Manufactured in a facility which follows current good manufacturing practices

Formula

Our Pure Glutamine is the highest quality glutamine available, giving you ultimate results.

Glutamine is produced in the muscles and is the most abundant amino acid in the body. It is important for many bodily functions including protein synthesis and immune function. The body is likely to go into a catabolic state if more glutamine is used than is produced, thus making it crucial for the supplement regimen of any high intensity sport.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) scoop two to three times daily. Optimal times are upon awakening, pre and post workout. Mix with your choice of beverage.

Precautions

Warning: Consult a physician prior to use if you have any medical conditions.

Do not use if pregnant or lactating.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Like us: Facebook.com/imsoalpha

BPA Free Non-toxic plastic

Be alpha and recycle

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Glutamine by IMSOALPHA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Glutamine by IMSOALPHA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions
Interaction report

Pure Glutamine by IMSOALPHA Drug Interactions

Want to check YOUR meds against Pure Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Pure Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Glutamine, from the product label.

IMSOALPHA

See all IMSOALPHA products
Name
ImSoAlpha
Street Address
117 Elk Drive, Unit E
City
Murrells Inlet
State
SC
ZipCode
29576
Phone Number
1.803.832.2542
Pharmacist Counseling Corner

Pure Glutamine by IMSOALPHA: Common Questions

Does Pure Glutamine by IMSOALPHA interact with any medications?
Yes. Based on its ingredients, Pure Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
L-glutamine is rated likely safe in pregnancy based on the data we hold. During breastfeeding, there isn't enough safety information, so talk with your doctor or pharmacist before taking a supplement dose — they can give you personalized advice.
What's the most common side effect?
Gastrointestinal upset is most common — bloating, gas, constipation, diarrhea, nausea, and stomach pain, especially at higher doses. These effects are usually mild and often settle if you lower the dose.
Can I take this if I have liver or kidney problems?
Only under medical supervision. Talk with your doctor first if either organ isn't working normally — they'll want to monitor you while you're taking it.
What is glutamine used for in the body?
Your body naturally makes and uses glutamine for muscle support, immune function, and intestinal health. This supplement provides extra amounts, especially helpful after surgery, serious illness, or in certain wasting conditions.
Does this product have any fillers or other ingredients?
No — it's pure L-glutamine powder with no inactive ingredients added.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Glutamine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Glutamine label
Go deeper

The Full Monographs Behind Pure Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Pure Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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