Red Sage 450 mg Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Red Sage 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Red Sage 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for heart and circulation support, angina (chest pain), high blood pressure.Based on those ingredients, 1,059 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Red Sage. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Red Sage 450 mg by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Red Sage 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Red Sage 450 mg by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Red Sage 450 mg contains one active ingredient: red sage (danshen), an herb used in traditional medicine. The capsule also contains gelatin and water as inactive ingredients.
Does it work?
Couldn't assess
The evidence for red sage isn't established in the data we hold. The product's labeling references acne, unstable angina, cancer, coronary heart disease, cirrhosis, and heart failure, but the effectiveness ratings for all these conditions show insufficient reliable evidence to rate — meaning we don't have solid clinical data to confirm whether red sage works for them.
How safe is it?
Well-documented data
When taken by mouth, red sage appears generally well tolerated by most people. The most commonly reported side effects in trials were upset stomach, itching, and reduced appetite; some people also reported drowsiness, dizziness, or headache, though it's unclear whether danshen was responsible.
The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe. Short-term use by adults may be considered, though quality varies between products and the herb does affect blood clotting.
Meds to double-check
Major interaction found
Before taking this product, check with your pharmacist if you use blood thinners or antiplatelet drugs (like warfarin or clopidogrel) — there's a Major risk of increased bleeding. Also double-check digoxin or other cardiac glycoside heart medications, blood pressure drugs, and any medications metabolized by your liver's enzyme systems (CYP1A2, CYP2C9, CYP2E1, CYP3A4) or cleared by p-glycoprotein.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Red sage may interest someone looking for traditional herbal support, but its effectiveness isn't established. If you're on any blood thinners, heart medications, blood pressure drugs, or medications your liver processes, talk to your pharmacist before starting — the interaction list is substantial.
Pregnant or breastfeeding folks should skip it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Red Sage 450 mg, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435213350 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 289464 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Red Sage 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Take 1 capsule, 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Red Sage 450 mg by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Red Sage 450 mg by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Red Sage
Interacts with1,059 drugs
Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems. Some early research is promising, but the evidence...
Red Sage monograph & interactionsOther (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Red Sage 450 mg by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
Red Sage 450 mg by TerraVita Premium Collection contains danshen, an herb with documented interactions across multiple medication types.
The most serious concern is with blood thinners and antiplatelet drugs (anticoagulants and antiplatelet agents) — danshen has antithrombotic effects and may increase bleeding risk when combined with these medications, especially clopidogrel. It also carries a Major interaction with digoxin (a heart medication), where danshen's structural similarity to cardiac glycosides may increase adverse effects.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions span several drug categories. Danshen may lower blood pressure beyond intended when taken with blood pressure medications (antihypertensives), and it can affect how your liver metabolizes certain drugs — specifically those processed by CYP1A2, CYP2C9, CYP2E1, and CYP3A4 enzymes.
Additionally, danshen may alter levels of drugs cleared by p-glycoprotein, a cellular transport system; one clinical study showed it raised levels of fexofenadine by about 27%.
Altogether, these interactions span 1,045 individual medications. If you take any prescription medication — especially blood thinners, heart drugs, blood pressure medications, or anything metabolized by your liver — check your exact medications with the search tool on this page before adding danshen.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Red Sage 450 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Red Sage 450 mg interact with 1,059 drugs. Click any drug to see the details.
1 of the 1 ingredient in Red Sage 450 mg interact with drugs. Each result below shows which ingredient is responsible. Red Sage
AbciximabReoPro
How Abciximab interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Read the full Red Sage + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageCytochrome P450 2e1 (cyp2e1) Substrates, Aspirin +3 Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Red Sage + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +4 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageCytochrome P450 2c9 (cyp2c9) Substrates, Glucuronidated Drugs +3 Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Read the full Red Sage + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Aspirin Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageP-glycoprotein Substrates, Anticoagulant/antiplatelet Drugs +1 Major
Interaction Summary
Danshen might alter the levels of drugs cleared by p-glycoprotein.
Read the full Red Sage + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Aspirin Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Red Sage + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Red Sage + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Red Sage 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Red SageAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Red Sage + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Red Sage 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Red Sage
Anticoagulant/Antiplatelet Drugs
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Danshen has been reported to have antithrombotic effects. Animal research also suggests that taking a danshen combination formula with clopidogrel exhibits a synergistic increase in antiplatelet aggregation and prolongation of coagulation time when compared with either taken alone.
Digoxin (Lanoxin)
Theoretically, using danshen with digoxin might increase the risk of adverse effects.
Danshen has structural and pharmacological similarities to cardiac glycosides.
Amlodipine (Norvasc)
Theoretically, taking danshen in combination with amlodipine may decrease the clinical effects of amlodipine.
In animal research, taking danshen orally in combination with amlodipine reduced blood levels of amlodipine by about 52%. This may have been due to induction of cytochrome P450 3A4 (CYP3A4) by danshen, which has been demonstrated in vitro. So far, this interaction has not been reported in humans.
Antihypertensive Drugs
Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that danshen can produce dose-dependent hypotensive effects. Furthermore, concomitant use with captopril appears to potentiate this effect.
Aspirin
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Research in healthy adult males shows that taking a combination of danshen and kudzu with aspirin increases plasma aspirin area under the curve by approximately 3.4-fold. Animal research also shows that taking a combination of danshen and kudzu (danshen-gegen formula) with aspirin increases maximal blood levels of aspirin and salicylic acid by approximately 4-fold and 3.7-fold, respectively, without impacting blood loss. Taking danshen increases the antiplatelet activity of aspirin and might increase the side effects of aspirin.
Clopidogrel (Plavix)
Theoretically, danshen may increase the risk of bleeding if taken with clopidogrel.
Clopidogrel is an antiplatelet prodrug that is metabolized by carboxyl esterase 1 (CES1) to an inactive metabolite. Animal research shows that a danshen combination formula decreases the activity of CES1, decreasing levels of the inactive metabolite in the blood and possibly increasing levels of the active metabolite. Animal research also suggests that taking a danshen combination formula with clopidogrel exhibits a synergistic increase in antiplatelet aggregation and prolongation of coagulation time when compared with either taken alone.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that danshen tincture and various constituents of danshen inhibit the activity of CYP1A2. However, this activity has not been shown in humans when theophylline, a CYP1A2 substrate, was used as a target drug.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro research shows that various constituents of danshen inhibit the activity of CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2E1.
In vitro research shows that various constituents of danshen inhibit the activity of CYP2E1. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Preliminary clinical research in healthy males shows that the administration of danshen for 10-14 days induces intestinal CYP3A4 and increases the clearance of midazolam, a CYP3A4 substrate. The maximum concentration of midazolam was decreased by 31% to 67%, and drug levels were decreased by 27% to 80%. However, a single dose of danshen has the opposite effect, increasing maximum concentrations of midazolam by 87%.
Fexofenadine (Allegra)
Danshen might increase the levels and clinical effects of fexofenadine.
Pharmacokinetic research in healthy volunteers shows that taking danshen extract 1 gram three times daily for 10 days prior to receiving fexofenadine 60 mg increases peak levels of fexofenadine, a p-glycoprotein substrate, by 27.4% and area under the curve (AUC) by 37.2%.
Glucuronidated Drugs
Theoretically, danshen might affect the levels and clinical effects of drugs requiring glucuronidation.
In vitro research shows that danshen induces the expression of glucuronosyltransferases. However, it also inhibits the activity of glucuronosyltransferases, including various members of the 1A and 2B families. The extent of inhibition of a specific glucuronosyltransferase seems to be dependent on whether or not the danshen is processed via 'sweating'. This type of processing may affect the levels of constituents in danshen that alter glucuronosyltransferase activity. So far, this interaction has not been reported in humans.
Midazolam (Versed)
Danshen might alter the levels and clinical effects of midazolam.
Preliminary clinical research in healthy males shows that the administration of danshen for 10-14 days induces intestinal CYP3A4 and increases midazolam clearance. The maximum concentration was decreased by 31% to 67%, and drug levels were decreased by 27% to 80%. However, a single dose of danshen has the opposite effect, increasing maximum concentrations of midazolam by 87%.
P-Glycoprotein Substrates
Danshen might alter the levels of drugs cleared by p-glycoprotein.
Pharmacokinetic research in healthy volunteers suggests that danshen might affect p-glycoprotein activity. Taking danshen extract 1 gram three times daily for 10 days prior to receiving fexofenadine 60 mg increases peak levels of fexofenadine, a p-glycoprotein substrate, by 27.4% and area under the curve (AUC) by 37.2%.
Rosuvastatin (Crestor)
Theoretically, danshen might increase the levels and clinical effects of rosuvastatin.
Animal research shows that a single dose of danshen increases levels of rosuvastatin at least 2-fold, possibly by increasing absorption and/or decreasing elimination. So far, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, danshen may increase the risk of bleeding if used with warfarin.
There have been several case reports of increased international normalized ratio (INR) after concomitant use of danshen and warfarin. Elevations in INR have occurred as early as 3-5 days after start of danshen. However, a clinical trial in adults taking warfarin with stable INR found that the addition of compound danshen dripping pills, containing danshen extract, Panax notoginseng, and borneol, 270 mg three times daily for 4 weeks did not alter INR levels or the average required warfarin dose when compared to baseline. These findings are consistent with animal research, which found no change in warfarin pharmacokinetics with the use of danshen. Other research in healthy adult males also shows that taking a combination of danshen and kudzu with warfarin does not increases plasma warfarin area under the curve, but may reduce plasma soluble thrombomodulin levels. However, other research shows that danshen might increase the rate of absorption and decrease the elimination rate of warfarin. Also, research in healthy adult males shows that taking a combination of danshen and kudzu with warfarin increases plasma area under the curve of danshensu, a constituent of danshen, by approximately 29.5-fold. Danshen should be used cautiously in patients taking warfarin.
Brand information
Manufacturer and brand details for Red Sage 450 mg, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Red Sage 450 mg by TerraVita Premium Collection: Common Questions
Does Red Sage 450 mg by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is red sage and what's it supposed to do?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Does quality matter between brands?
I'm on a blood thinner — is this safe for me?
Can red sage affect how my other medications work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Red Sage 450 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Red Sage 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Danshen 28 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. PubMed
- Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.
- Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. DOI
- Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5.
- Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. PubMed
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. PubMed
- Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed
- Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. PubMed
- Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.
- Chu Y, Zhang L, Wang XY, Guo JH, Guo ZX, Ma XH. The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Ethnopharmacol. 2011 Oct 11;137(3):1457-61. PubMed
- Ma S, Ju W, Dai G, Zhao W, Cheng X, Fang Z, Tan H, Wang X. Synergistic effects of clopidogrel and fufang danshen dripping pills by modulation of the metabolism target and pharmacokinetics. Evid Based Complement Alternat Med. 2014;2014:789142. PubMed
- Qiu F, Jiang J, Ma Y, Wang G, Gao C, Zhang X, Zhang L, Liu S, He M, Zhu L, Ye Y, Li Q, Miao P. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evid Based Complement Alternat Me PubMed
- Qiu F, Zeng J, Liu S, He M, Zhu L, Ye Y, Miao P, Shen S, Jiang J. Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers. Evid Based Complement Alternat Med. 2014;2014:473213. PubMed
- Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine. 2010 Sep;17(11):868-75. PubMed
- Wang X, Yeung JH. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine. 2012 Feb 15;19(3-4):348-54. PubMed
- Wen JH, Xiong YQ. The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):205-11. PubMed
- Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 2014 Jul 3;154(3):672-86. PubMed
- Zhou X, Chan K, Yeung JH. Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes. Drug Metabol Drug Interact. 2012 Mar 2;27(1):9-18.
- Zhou L, Wang S, Zhang Z, Lau BS, Fung KP, Leung PC, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 2012 Sep 28;143(2):648-55. PubMed
- Lv C, Liu C, Yao Z, et al. The clinical pharmacokinetics and pharmacodynamics of warfarin when combined with compound danshen: a case study for combined treatment of coronary heart diseases with atrial fibrillation. Front Pharmacol. 2017 Nov 21;8:826. PubMed
- Yin QS, Chen L, Mi RH, Ai H, Yin JJ, Liu XJ, Wei XD. Efficacy and safety of danshen compound tablets in preventing thalidomide-associated thromboembolism in patients with multiple myeloma: a multicenter retrospective study. Med Sci Monit. 2016 Oct 20;22:3 PubMed
- Zhang H, Han X, Li Y, Li H, Guo X. Effects of danshen tablets on pharmacokinetics of amlodipine in rats. Pharm Biol. 2019;57(1):306-309. PubMed
- Zhang Y, Yang M, Ho NJ, et al. Is it safe to take Radix Salvia Miltiorrhiza - Radix Pueraria Lobate product with warfarin and aspirin? A pilot study in healthy human subjects. J Ethnopharmacol. 2020 Nov 15;262:113151. PubMed
- Ma XJ, Duan WH, Zhang Y, et al. Combination of activating blood circulation and detoxifying Chinese medicines played an anti-inflammatory role in unstable angina patients after percutaneous coronary intervention: A multicenter, open-labeled, randomized co
- Liu J, Shi Y, Wu C, et al. Comparison of sweated and non-sweated ethanol extracts of Salvia miltiorrhiza Bge. (Danshen) effects on human and rat hepatic UDP-glucuronosyltransferase and preclinic herb-drug interaction potential evaluation. Curr Drug Metab
- Zheng D, Zhang W, Hou M, et al. Evaluation of herb-drug interactions between compound Danshen dripping pills and clopidogrel based on the pharmacokinetics and pharmacodynamics in rats. Biomed Chromatogr. 2023;37(9):e5684. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC