Interactions on record — worth a quick check against your medications. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

SerraDefend Ingredients & Drug Interactions

by Balance One

SerraDefend label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SerraDefend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SerraDefend is a dietary supplement by Balance One with 9 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase, Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SerraDefend by Balance One

Ask about any prescription or over-the-counter medication and we check it for interactions with SerraDefend by Balance One — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SerraDefend by Balance One

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.

SerraDefend contains nine active ingredients, all enzymes that break down different compounds in food. Nattokinase (derived from fermented soy) and serrapeptase (a protease from a bacteria) are both fibrinolytic enzymes designed to support circulation.

Protease, amylase, cellulase, glucoamylase, beta-glucanase, hemicellulase, and chitosanase work as digestive aids to help break down proteins, carbohydrates, fats, and fiber. The capsule itself contains maltodextrin and cellulose as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The effectiveness data we hold rates all listed conditions as having insufficient reliable evidence for nattokinase and serrapeptase. These include angina, atherosclerosis, cancer, cardiovascular disease, chronic fatigue syndrome, chronic bronchitis, asthma, back pain, and osteoporosis.

We have no established effectiveness ratings for the other enzyme ingredients in this product.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Nattokinase Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated but may cause digestive upset or allergic reactions in some people. Rarely, occupational exposure to proteolytic enzymes has been linked to allergic rhinitis, conjunctivitis, or asthma.

Nattokinase and serrapeptase are generally tolerated short-term; however, nattokinase's blood-thinning effect means caution for anyone with bleeding risk, and serrapeptase's long-term safety is not well studied. The most common side effects of serrapeptase are epigastric pain, gastrointestinal upset, and nausea, though these appear to occur at the same rate as placebo in trials.

Nattokinase rarely causes hypersensitivity reactions, including anaphylaxis, in individuals sensitive to natto, with symptoms typically occurring within two hours of ingestion.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Nattokinase Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Nattokinase, Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using SerraDefend if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin)—nattokinase and serrapeptase both increase bleeding risk, and there's a documented case of brain hemorrhage. Also check if you take blood pressure medications, since nattokinase may lower blood pressure further.

Altogether, these interactions span 289 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

SerraDefend is an enzyme blend aimed at digestion and circulation support, but the evidence for its intended uses isn't established in the data we hold. The main caution is if you take blood thinners, antiplatelet drugs, or blood pressure medications—the nattokinase and serrapeptase here can significantly interact with these, raising bleeding and low blood pressure risks.

If you're on any of those drugs or have a bleeding disorder, talk with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SerraDefend, straight from the product label.

Brand Balance One
Barcode (UPC) X002WL6VGX
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259514
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SerraDefend by Balance One, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
X002WL6VGX
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Cellulase0 NP--
Glucoamylase0 NP--
Beta-Glucanase0 NP--
Hemicellulase0 NP--
Nattokinase0 NP--
Chitosanase50 mg--
Serrapeptase0 NP--

Other ingredients: Maltodextrin, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two (1) capsule once daily, without food, or as directed by a healthcare professional.

Formulation

Vegan

No Gluten No Preservatives No Dairy No Nuts No Artificial Colors or Flavors No Wheat Non-GMO

Systemic and digestive enzymes

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: If you have a medical condition, are on medication, or are pregnant or nursing, please see the advice of a qualified health care professional before using.

Do not use if seal is broken or missing.

Keep out of reach of children.

Manufactured in a cGMP facility that also processes wheat, milk, egg & soy.

Formula

Enteric coated serrapeptase to safely reach your gut Nattokinase, chitosanase, cellulase, and more

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SerraDefend by Balance One label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SerraDefend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SerraDefend by Balance One

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

0 NP per serving

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Cellulase

0 NP per serving

Glucoamylase

0 NP per serving

Beta-Glucanase

0 NP per serving

Hemicellulase

0 NP per serving

Nattokinase

Interacts with
289 drugs
0 NP per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Chitosanase

50 mg per serving

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Maltodextrin, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

SerraDefend by Balance One Drug Interactions

Want to check YOUR meds against SerraDefend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289
Serrapeptase 122

Individual Drug Interactions

The ingredients in SerraDefend interact with 289 drugs. Click any drug to see the details.

2 of the 9 ingredients in SerraDefend interact with drugs. Each result below shows which ingredient is responsible. Nattokinase Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in SerraDefend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SerraDefend, from the product label.

Balance One

See all Balance One products
Name
Balance One Supplements Inc.
Street Address
3 Germay Dr, Ste 4-4335
City
Wilmington
State
DE
ZipCode
19804
Web Address
BalanceOne.com
Pharmacist Counseling Corner

SerraDefend by Balance One: Common Questions

Does SerraDefend by Balance One interact with any medications?
Yes. Based on its ingredients, SerraDefend has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SerraDefend contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take SerraDefend with aspirin or other blood thinners?
Not without checking first with your doctor or pharmacist. Nattokinase and serrapeptase in this product have blood-thinning effects and may increase your risk of bleeding. There's even a case report of intracranial hemorrhage in someone who added nattokinase to aspirin therapy.
Will SerraDefend help with my heart health or blood vessel problems?
The conditions these enzymes are often marketed for—atherosclerosis, cardiovascular disease, angina—are all rated as having insufficient reliable evidence. We simply don't have established proof they work for these purposes.
What are the most common side effects?
Serrapeptase may cause epigastric pain, gastrointestinal upset, and nausea, though these appear to happen at the same rate as placebo in trials. Protease can occasionally cause digestive upset or allergic reactions.
Is SerraDefend safe during pregnancy?
The three enzymes with safety data on file—protease, nattokinase, and serrapeptase—all lack enough information to know they're safe during pregnancy and should be avoided unless your doctor prescribes it. Talk with your doctor or pharmacist for personalized advice.
What does nattokinase do in this product?
Nattokinase is a fibrinolytic enzyme derived from fermented soy that's designed to support circulation. Some clinical research suggests it may lower blood pressure, which is why it shouldn't be combined with blood pressure medications without medical supervision.
Can I take this if I have high blood pressure?
Check with your doctor or pharmacist first. Nattokinase in SerraDefend may theoretically lower your blood pressure further, which could be risky if you're already on blood pressure medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SerraDefend label
Go deeper

The Full Monographs Behind SerraDefend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph → Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

SerraDefend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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