Interactions on record — worth a quick check against your medications. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Sleep & Relax Ingredients & Drug Interactions

by Gaia Herbs

Sleep & Relax label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep & Relax against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sleep & Relax is a dietary supplement by Gaia Herbs with 9 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation and calming.Based on those ingredients, 1,115 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Valerian, organic Passionflower leaf freeze-dried extract, Sweet Marjoram aerial parts essential oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep & Relax by Gaia Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep & Relax by Gaia Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sleep & Relax by Gaia Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 9 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (290 mg) without saying how much of each component you get.

Sleep & Relax contains 9 ingredients, most of which are herbal extracts and essential oils blended to promote relaxation. The active ingredients are English lavender flower essential oil, passion flower leaf extract, valerian (in two forms—whole herb and freeze-dried root extract), lemon balm (in two forms—whole herb and freeze-dried extract), California poppy (whole herb and freeze-dried extract), and sweet marjoram aerial parts essential oil.

These are combined in a vegan capsule. The product also contains inactive ingredients listed as a vegan capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Sleep support and relaxation.
  • We looked for evidence on: Anxiety, Insomnia, Muscle cramps, Restless legs syndrome (RLS), Stress, Nervousness — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Valerian is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety, Insomnia.

The evidence for this product's effectiveness varies by ingredient. Passion flower and valerian are both rated Possibly Effective for insomnia and possibly effective for pre-procedural anxiety.

Lemon balm is rated Possibly Effective for stress and depression, as well as cold sores. Lavender has limited effectiveness data in our records—it's rated possibly effective for period pain but possibly ineffective for cancer-related pain, with insufficient evidence for anxiety and several other uses.

California poppy and marjoram lack sufficient reliable evidence to rate for the conditions this product targets, so we cannot confirm how well they work based on the data we hold. If you're looking for sleep support, passion flower and valerian have the most established evidence in this formula.

The evidence, ingredient by ingredient Lavender Lemon Balm California Poppy Marjoram Passion Flower Valerian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lavender is generally well tolerated when taken by mouth, though the most common side effects include breath odor, constipation, diarrhea, indigestion, burping, headache, and nausea. The essential oil is toxic if swallowed and can irritate skin in some people.

Passion flower is generally well tolerated short-term and causes drowsiness as its main side effect—though confusion, dizziness, and sensitivity reactions have been reported. Valerian is generally well tolerated for short-term use and commonly causes dizziness, drowsiness, mental slowness, headache, and vivid dreams.

If you stop valerian suddenly after prolonged use, withdrawal symptoms like anxiety, irritability, and insomnia may occur, so taper slowly. Lemon balm is well tolerated for short-term use but long-term safety is not well studied.

California poppy has limited safety data overall. All five of these ingredients should be avoided in pregnancy, and most should be avoided or used cautiously while breastfeeding—talk to your doctor before use if either applies to you.

Side effects, ingredient by ingredient Lavender Lemon Balm California Poppy Marjoram Passion Flower Valerian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — California Poppy, Lemon Balm, Marjoram, Lavender, Valerian, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,116 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sleep & Relax, double-check with your pharmacist if you take any CNS depressants (sleep aids, anxiety medications, pain relievers, antihistamines that cause drowsiness), blood thinners or antiplatelet drugs like aspirin or warfarin, thyroid hormone replacement therapy, anticholinergic drugs (used for overactive bladder or certain neurological conditions), cholinergic drugs (like donepezil for dementia), or alcohol. Several of these carry Moderate severity interactions with the valerian, lemon balm, passion flower, and marjoram in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-herbal sleep and relaxation formula best suited for people seeking natural support for occasional sleeplessness or pre-procedure anxiety who aren't taking sedating medications, blood thinners, thyroid pills, or certain neurological drugs. If you take any prescription medication—especially anything that makes you drowsy—check your exact drugs with the tool on this page before you start.

Talk to your pharmacist about whether the combination is safe for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep & Relax, straight from the product label.

Brand Gaia Herbs
Net contents 50 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273335
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep & Relax by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
25
IngredientAmount% DV
Proprietary Blend290 mg--
English Lavender flower essential oil0 NP--
organic Passionflower leaf freeze-dried extract387 mg--
organic Valerian203 mg--
organic Valerian root freeze-dried extract87 mg--
organic Lemon Balm0 NP--
organic Lemon Balm leaf freeze-dried extract0 NP--
organic California Poppy0 NP--
organic California Poppy aerial parts freeze-dried extract0 NP--
Sweet Marjoram aerial parts essential oil0 NP--

Other ingredients: vegan Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

New Look Same Formula

Gaia Herbs delivers unprecedented traceability by screening every product and sharing the results online. Learn more about your herbs by entering the unique ID # below at meetyourherbs.com.

Purity - Keep it clean All products are screened for pesticides, microbes & heavy metals. Integrity - Keep it real See the proof at meetyourherbs.com, the world's first herb traceability platform. Potency - Keep it strong Concentrated plant extracts are delivered in our patented Phyto-Caps technology. Discover our guiding truths at: Facebook Instagram @gaiaherbs

A partnership of mutual benefits Sleep & Relax is produced in Tuscany, Italy, by Aboca, the herbal supplement leader in Europe since 1978. Gaia Herbs' partnership with Aboca is born from a mutual belief in sustainable product development, dedication to quality, and a deep respect for science and nature working in harmony. Aboca

Seals/Symbols

USDA Organic

EST 1987 USA Integrity Purity Potency

Certified B Corporation

Formulation

Sleep Support Promotes a sense of calm and helps prepare your body for a good night's rest

Certified Organic by Oregon Tilth

Product of Italy

Vegan

Gluten-free Soy-free

Formula

With Lavender, Lemon Balm & Passionflower

FDA Statement of Identity

Herbal supplement

Suggested/Recommended/Usage/Directions

Suggested Use Take 2 capsules 1 hour before bed.

Precautions

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use.

Store away from children.

Use only as directed on label. Safety-sealed for your protection.

Storage

Keep bottle capped at all times and store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Gaia Herbs Connecting Plants & People Since 1987

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep & Relax by Gaia Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep & Relax label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep & Relax by Gaia Herbs

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Passionflower leaf freeze-dried extract

Interacts with
836 drugs
387 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Organic Passionflower leaf freeze-dried extract monograph & interactions

Organic Valerian

Interacts with
902 drugs
203 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Organic Valerian monograph & interactions

Organic Valerian root freeze-dried extract

Interacts with
902 drugs
87 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Organic Valerian root freeze-dried extract monograph & interactions

Other (inactive) ingredients: Vegan Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep & Relax by Gaia Herbs Drug Interactions

Want to check YOUR meds against Sleep & Relax?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,115Drugs
600 Moderate 515 Minor

Ingredients driving the most interactions

organic Valerian 902
organic Passionflower leaf freeze-dried extract 836
Sweet Marjoram aerial parts essential oil 338
organic Lemon Balm 264
English Lavender flower essential oil 248

Individual Drug Interactions

The ingredients in Sleep & Relax interact with 1,115 drugs. Click any drug to see the details.

6 of the 9 ingredients in Sleep & Relax interact with drugs. Each result below shows which ingredient is responsible. organic Valerian organic Passionflower leaf freeze-dried extract Sweet Marjoram aerial parts essential oil organic Lemon Balm English Lavender flower essential oil organic California Poppy

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep & Relax with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Valerian6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
organic Valerian full monograph & interactions

organic Passionflower leaf freeze-dried extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
organic Passionflower leaf freeze-dried extract full monograph & interactions

Sweet Marjoram aerial parts essential oil3 drug types · 338 drugs

Anticholinergic Drugs

In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity. Theoretically, using marjoram in medicinal amounts along with anticholinergic drugs might decrease the effectiveness of marjoram or the anticholinergic agent.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion. Theoretically, marjoram might increase the risk of bleeding when used in medicinal amounts along with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Cholinergic Drugs

In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity. Theoretically, using marjoram in medicinal amounts along with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Sweet Marjoram aerial parts essential oil full monograph & interactions

organic Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
organic Lemon Balm full monograph & interactions

English Lavender flower essential oil1 drug type · 248 drugs

Cns Depressants

Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.

Likelihood Unlikely Evidence D
English Lavender flower essential oil full monograph & interactions

organic California Poppy1 drug type · 248 drugs

Cns Depressants

Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Laboratory research shows that California poppy has sedative effects.

Likelihood Possible Evidence D
organic California Poppy full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep & Relax, from the product label.

Gaia Herbs

See all Gaia Herbs products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Drive
City
Brevard
State
NC
ZipCode
28712
Web Address
www.gaiaherbs.com
Pharmacist Counseling Corner

Sleep & Relax by Gaia Herbs: Common Questions

Does Sleep & Relax by Gaia Herbs interact with any medications?
Yes. Based on its ingredients, Sleep & Relax has a known interaction with 1,115 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep & Relax contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against this product during pregnancy—passion flower and valerian are rated possibly unsafe, and the others lack enough safety information. While breastfeeding, most ingredients should be avoided or used only under your doctor's guidance. Talk to your doctor or pharmacist before using either one.
What are the most common side effects I might experience?
Drowsiness, dizziness, headache, and vivid dreams are the most common. Some people report nausea, indigestion, constipation, or diarrhea. If you stop taking it suddenly after long-term use, you may experience withdrawal symptoms like anxiety or insomnia—taper slowly instead.
Will this help me sleep?
Passion flower and valerian in this formula are rated Possibly Effective for insomnia, so there's some evidence they may help. Lemon balm and lavender have less established evidence for sleep specifically in our data. Results vary from person to person.
Is it safe to drink alcohol while taking this?
No. Valerian can have additive sedative effects with alcohol, which may cause excessive drowsiness and impaired judgment. Avoid alcohol while using this product.
What is each ingredient supposed to do?
Valerian and passion flower are included for their sedative and calming effects on the nervous system. Lavender, lemon balm, and California poppy are added for their relaxation properties. Marjoram rounds out the blend as an essential oil. Together, they're meant to promote calm and sleep.
Can I take this long-term?
Long-term safety for most of these ingredients is not well studied. Valerian in particular should be used cautiously long-term—if you stop abruptly, you may experience withdrawal symptoms. Talk to your pharmacist about how long it's safe for you to use this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep & Relax label
Go deeper

The Full Monographs Behind Sleep & Relax’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lavender

Interacts with 248 drugs

Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...

Read the full Lavender monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

California Poppy

Interacts with 248 drugs

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are...

Read the full California Poppy monograph → Herb & supplement monograph

Marjoram

Interacts with 338 drugs

Marjoram is a Mediterranean kitchen herb related to oregano that is widely used in food and traditional medicine for digestive, sleep, and respiratory complaints. Most of its health claims r...

Read the full Marjoram monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph →
Sources

Sources & How We Checked

Sleep & Relax's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 102 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lavender 20 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:123-7. PubMed
  4. Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
  5. Coulson IH and Khan AS. Facial 'pillow' dermatitis due to lavender oil allergy. Contact Dermatitis 1999;41(2):111. PubMed
  6. Woelk, H. and Schlafke, S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. PubMed
  7. Kasper, S., Gastpar, M., Muller, W. E., Volz, H. P., Moller, H. J., Dienel, A., and Schlafke, S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, plac
  8. Uehleke, B., Schaper, S., Dienel, A., Schlaefke, S., and Stange, R. Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. Phytomedicine. 6-15-2012;19(8-9):665-671. PubMed
  9. Brandao FM. Occupational allergy to lavender oil. Contact Dermatitis 1986;15(4):249-250. PubMed
  10. Rademaker M. Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 1994;31(1):58-59. PubMed
  11. Kasper S, Gastpar M, Müller WE, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
  12. Farshbaf-Khalili A, Kamalifard M, Namadian M. Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complement Ther Clin Pract 2018;31:132-8. PubMed
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  20. Simaei SR, Askari VR, Rostami M, et al. Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial. Fitoterapia 2023;172:105720. PubMed

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Passion Flower 19 references
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  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
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Valerian 37 references
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  24. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
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  31. Wells SR. International intravenous administration of a crude valerian root extract. NACCT 1995;33:542.
  32. Aydinoglu U, Özcan H, Yücel A, Yücel N, Mutlu M. Valerian induced hypomania: a case report. Bull Clin Psychopharma 2012;22(Suppl. 1):S63.
  33. Mirabi P, Mojab F. The effects of valerian root on hot flashes in menopausal women. Iran J Pharm Res 2013;12(1):217-22.
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  37. Hajizadeh I, Jamshidi M, Kazemi M, Kargar H, Sadeghi T. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial. Ther Apher Dial 2023.

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Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

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California Poppy 3 references
  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

See these in context on the California Poppy monograph →

Marjoram 11 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
  3. Farkas, J. Perioral dermatitis from marjoram, bay leaf and cinnamon. Contact Dermatitis 1981;7(2):121. PubMed
  4. Anderson C, Lis-Balchin M, Kirk-Smith M. Evaluation of massage with essential oils on childhood atopic eczema. Phytother Res 2000;14(6):452-6. PubMed
  5. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
  6. Chung, Y. K., Heo, H. J., Kim, E. K., Kim, H. K., Huh, T. L., Lim, Y., Kim, S. K., and Shin, D. H. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol.Cells 4-30-2001;11(2):137-143. DOI
  7. Yazdanparast, R. and Shahriyary, L. Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascul.Pharmacol 2008;48(1):32-37. PubMed
  8. Mohamed MS, Saad HH, and Abd El Khalek MG. Daily consumption of marjoram oil improve the health status of patients with asthma. Pakistan Journal of Nutrition. 2008;7(2):312-316. DOI
  9. Bina F, Rahimi R. Sweet marjoram: a review of ethnopharmacology, phytochemistry, and biological activities. J Evid Based Complementary Altern Med 2017;22(1):175-85.
  10. Haj-Husein I, Tukan S, Alkazaleh F. The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomized controlled pilot study. J Hum Nutr Diet 2016;29(1):105-11.
  11. Chahra C, Anis H, Bissene D, et al. The effect of Origanum majorana tea on motor and non-motor symptoms in patients with idiopathic Parkinson's disease: A randomized controlled pilot study. Parkinsonism Relat Disord. 2021 Oct;91:23-7. PubMed

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