Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Sleep Tonight Ingredients & Drug Interactions

by Nature's Way

Sleep Tonight label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep Tonight against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sleep Tonight is a dietary supplement by Nature's Way with 5 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,534 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Epimedium Aerial Parts Extract, L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep Tonight by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep Tonight by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sleep Tonight by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Stress-Reducing Proprietary Blend” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.
  • “Cortisol-Reducing Proprietary Blend” is a proprietary blend — the label gives one combined amount (225 mg) without saying how much of each component you get.
  • “Magnolia Bark Extract” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Sleep Tonight contains 6 ingredients. The active ones are L-theanine, a compound that may support relaxation; phosphatidylserine, which plays a role in brain cell health; ashwagandha (supplied as Sensoril), an herb used for stress and sleep; and three botanical extracts: honokiol from magnolia bark, epimedium aerial parts, and magnolol.

The product also includes a stress-reducing proprietary blend and a cortisol-reducing proprietary blend, whose exact components aren't detailed on the label. The tablet is made up of standard inactive ingredients like cellulose, magnesium stearate, and silica — common binding and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: reduce stress and promote restful sleep.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Insomnia, Stress, Sleep quality, Sleep onset — and 1 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Insomnia, Stress.

The evidence for Sleep Tonight's ingredients is mixed. Ashwagandha has possibly effective ratings for insomnia, anxiety, stress, and generalized anxiety disorder — the main uses you'd expect from a sleep supplement.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease, though that's not a sleep benefit. L-theanine is possibly effective for cognitive function, but evidence for anxiety, sleep, and other conditions in its monograph is insufficient.

For honokiol, epimedium, and magnolol, we hold no effectiveness data.

The evidence, ingredient by ingredient Theanine Ashwagandha Magnolia Horny Goat Weed Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine and phosphatidylserine are generally well tolerated in the short term, though long-term safety isn't fully studied. Ashwagandha is generally well tolerated in the short term, but the data are limited.

Side effects can include headaches, drowsiness, increased sleep duration, and dream activity (from L-theanine); flatulence, nausea, gastrointestinal upset, and insomnia, especially at higher doses (from phosphatidylserine); and diarrhea, gastrointestinal upset, nausea, and vomiting (from ashwagandha, though these are uncommon at typical doses). Rare serious concerns with ashwagandha include acute liver damage and hepatitis.

Pregnancy and breastfeeding: L-theanine, phosphatidylserine, and ashwagandha all lack sufficient safety data in pregnancy and lactation — the facts advise against use during both.

Side effects, ingredient by ingredient Theanine Ashwagandha Magnolia Horny Goat Weed Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Horny Goat Weed, Ashwagandha, Phosphatidylserine, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,535 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sleep Tonight, check whether you're on blood pressure-lowering drugs (antihypertensives) — both L-theanine and ashwagandha may intensify their effects. If you take sedatives, anti-anxiety drugs, benzodiazepines, or other CNS depressants, ashwagandha and L-theanine may increase drowsiness.

Double-check if you're on diabetes medications, thyroid hormone, immunosuppressants, anticholinergic drugs, or cholinergic drugs — ashwagandha and phosphatidylserine interact with these. Run your medications through the tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sleep Tonight may help you with sleep and stress if you don't take medications that interact with its ingredients. If you're on blood pressure drugs, sedatives, benzodiazepines, diabetes medications, thyroid replacement, or immune suppressants, talk to your pharmacist before starting — ashwagandha's interactions are the main concern.

Pregnant or breastfeeding women should skip this product. Check your exact medications on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep Tonight, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948004584
Net contents 28 Tablet(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328062
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep Tonight by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
28
UPC/BARCODE
763948004584
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
L-Theanine0 NP--
Stress-Reducing Proprietary Blend250 mg--
Cortisol-Reducing Proprietary Blend225 mg--
Honokiol3 mg--
Phosphatidylserine50 mg--
Magnolia Bark Extract0 NP--
Epimedium Aerial Parts Extract0 NP--
Magnolol1.5 mg--
Sensoril0 NP--

Other ingredients: Cellulose, Sodium Croscarmellose, Stearic Acid, Calcium Silicate, Magnesium Stearate, Silica, Hypromellose, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

A good day starts with a good night Helps reduce stress to promote restful sleep

Gluten free. No wheat, dairy, or gelatin.

Vegan Gelatin Free

Vegan Gelatin Free

Bottled and tested in the USA

Melatonin Free

Reduces stress to help promote restful sleep

Supports restful sleep during stressful times Supports adrenal health and balanced cortisol levels

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Warning: Do not use if you are pregnant or nursing. If you are taking any medications, consult a healthcare professional before use.

Individuals with diabetes should monitor blood glucose levels closely while taking this product.

Contains soy.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Sensoril is a registered trademark of Natreon, Inc. and is protected under U.S. Patent No. 7,318,938.

Copyright 2024 Nature's Way Brands, LLC

Seals/Symbols

Vegan Gelatin Free

General Statements

Bottle made from 50% post-consumer recycled plastic

LHBX00458.D01 BLK45D

Explore more products at naturesway.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Sensoril Clinically studied Ashwagandha

With ongoing use, clinically studied Sensoril ashwagandha supports a healthy response to mind and body stress Formulated with a Stress-Reducing Proprietary Blend of Sensoril ashwagandha and L-theanine

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 tablet before bedtime, or as recommended by a healthcare professional. For nightly use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep Tonight by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep Tonight label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep Tonight by Nature's Way

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stress-Reducing Proprietary Blend

250 mg per serving

Cortisol-Reducing Proprietary Blend

225 mg per serving

Phosphatidylserine

Interacts with
219 drugs
50 mg per serving Form: Soybean Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Cellulose, Sodium Croscarmellose, Stearic Acid, Calcium Silicate, Magnesium Stearate, Silica, Hypromellose, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep Tonight by Nature's Way Drug Interactions

Want to check YOUR meds against Sleep Tonight?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,534Drugs
1,485 Moderate 49 Minor

Ingredients driving the most interactions

Sensoril 1,372
Epimedium Aerial Parts Extract 963
L-Theanine 565
Magnolia Bark Extract 351
Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Sleep Tonight interact with 1,534 drugs. Click any drug to see the details.

5 of the 5 ingredients in Sleep Tonight interact with drugs. Each result below shows which ingredient is responsible. Sensoril Epimedium Aerial Parts Extract L-Theanine Magnolia Bark Extract Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep Tonight with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Epimedium Aerial Parts Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Epimedium Aerial Parts Extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Magnolia Bark Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia Bark Extract full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep Tonight, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Sleep Tonight by Nature's Way: Common Questions

Does Sleep Tonight by Nature's Way interact with any medications?
Yes. Based on its ingredients, Sleep Tonight has a known interaction with 1,534 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep Tonight contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me sleep?
Ashwagandha, one of the main ingredients, has possibly effective evidence for insomnia. L-theanine and phosphatidylserine may help with relaxation and cognition, though the sleep evidence is less clear. Your results may vary.
Can I take this if I'm pregnant or breastfeeding?
No. All three ingredients we could check — L-theanine, phosphatidylserine, and ashwagandha — lack enough safety data in pregnancy and breastfeeding, and the facts advise against use during both. Talk with your OB or midwife for options.
What are the most common side effects?
Headaches and drowsiness are possible from L-theanine. Phosphatidylserine may cause flatulence, nausea, or gastrointestinal upset. Ashwagandha can cause nausea, diarrhea, or gastrointestinal upset, though these are uncommon at typical doses.
Is this safe to take long-term?
Long-term safety isn't well studied for any of the main ingredients. The facts note that L-theanine, phosphatidylserine, and ashwagandha are generally well tolerated short-term, but we don't have solid data on years of use. If you want to take it regularly, check with your pharmacist.
What does ashwagandha do in this product?
Ashwagandha is an herb used for stress and sleep. It has possibly effective evidence for insomnia, anxiety, stress, and generalized anxiety — the main reasons it's in a sleep supplement. It may help you relax and wind down.
What's the proprietary blend, and why isn't it listed?
The label mentions a stress-reducing proprietary blend and a cortisol-reducing proprietary blend, but the exact ingredients and amounts aren't disclosed. Manufacturers keep blends proprietary to protect their formulas, but it means you don't know the full breakdown — ask the company directly if you need those details.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep Tonight label
Go deeper

The Full Monographs Behind Sleep Tonight’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Sleep Tonight's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
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Magnolia 9 references
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Horny Goat Weed 11 references
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Ashwagandha 32 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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