Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

SynovX Al Ingredients & Drug Interactions

by XYMOGEN

SynovX Al label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SynovX Al against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SynovX Al is a dietary supplement by XYMOGEN with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 702 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SynovX Al by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with SynovX Al by XYMOGEN — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of SynovX Al by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “SynovX Al Proprietary Blend” is a proprietary blend — the label gives one combined amount (469 mg) without saying how much of each component you get.

SynovX Al contains 3 active ingredients. Hesperidin is a plant compound (flavonoid) that may help with joint and connective tissue support, though the evidence for its use in obesity and high cholesterol is limited.

The product also includes xanthohumol and native collagen type II, both aimed at joint and tissue health. The remaining ingredients are inactive—dicalcium phosphate, microcrystalline cellulose, ascorbyl palmitate, silica, medium-chain triglyceride oil, and the capsule itself.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hesperidin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: joint tissue and immune support.
  • We looked for evidence on: Rheumatoid arthritis (RA), osteoarthritis, joint inflammation, cartilage health.
  • The closest evidence on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA) (Natural Medicines).

The evidence we have on hesperidin is mixed. For obesity and high cholesterol, it's rated possibly ineffective—meaning studies don't show it works well for those goals.

For nonalcoholic fatty liver disease, we don't have enough reliable evidence to rate it one way or the other. We hold no effectiveness data on xanthohumol or native collagen type II in our system.

The evidence, ingredient by ingredient Hesperidin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin is generally well tolerated when used as a supplement in the short term, though high-quality long-term safety data is limited. Safety information for pregnancy and breastfeeding is not enough to know either way—the rating is mixed between likely safe and possibly safe—so you should talk with your doctor or pharmacist about whether it's right for you if you're pregnant or nursing.

One case of allergic skin rash was reported with a topical hesperidin product in someone with no known allergies, but this is rare.

Side effects, ingredient by ingredient Hesperidin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 702 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting SynovX Al, double-check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin or clopidogrel)—hesperidin may increase bleeding risk. Also mention it if you're on blood pressure medications, sedating drugs, calcium channel blockers (verapamil or diltiazem), celiprolol, or any medication cleared by your liver through a specific transport system, because hesperidin can affect how these drugs work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

SynovX Al is marketed for joint and connective tissue support, but the evidence supporting hesperidin for obesity and cholesterol is weak. If you take blood thinners, heart medications, blood pressure drugs, or sedating medications, you'll want to clear this with your doctor or pharmacist first—the hesperidin content could affect how those drugs work.

Pregnancy and breastfeeding safety isn't well established, so check with your healthcare provider in those situations too.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SynovX Al, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149004378
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 218145
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SynovX Al by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
871149004378
IngredientAmount% DV
Hesperidin0 NP--
Xanthohumol0 NP--
SynovX Al Proprietary Blend469 mg--
b-2Cool Native Collagen Type II0 NP--

Other ingredients: Dicalcium Phosphate, Capsule, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica, Medium-Chain Triglyceride Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Professional Use Only Not for resale on third-party websites, including, but not limited to, Amazon and eBay.

Scan to learn more! This package is completely recyclable

Suggested/Recommended/Usage/Directions

Directions: Take two capsules on an empty stomach, or use as directed by your healthcare practitioner. For best results, take the capsules at bedtime.

Precautions

Consult a healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Storage: Keep closed in a cool, dry place out of reach of children.

Formula

SynovX AI provides a proprietary blend of ingredients that specifically targets tissues, immune cells, and cytokines in joints. Type II collagen is the main structural protein in cartilage, and research suggests that low-dose, native-form type II collagen- as found in b-2Cool-positively influences the immune response in joints via a mechanism called oral tolerization (a desensitization process). Xanthohumol, from hops and hesperidin complement the activities of b-2Cool to deliver specialized joint support. Let SynovX AI help you stay active and moving!

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

Does Not Contain: Wheat, gluten, corn, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Joint comfort support

Seals/Symbols

ePV (ePedigree Verification)

Vegetarian caps

GMP complaint Third-party verified

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

b2Cool is a registered trademark licensed by Bioiberica, S.A.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SynovX Al by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SynovX Al label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SynovX Al by XYMOGEN

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SynovX Al Proprietary Blend

469 mg per serving
  • › Hesperidin
  • › Xanthohumol
  • › B-2Cool Native Collagen Type II

Other (inactive) ingredients: Dicalcium Phosphate, Capsule, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica, Medium-Chain Triglyceride Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

SynovX Al by XYMOGEN Drug Interactions

Want to check YOUR meds against SynovX Al?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
702Drugs
702 Moderate

Ingredients driving the most interactions

Hesperidin 702

Individual Drug Interactions

The ingredients in SynovX Al interact with 702 drugs. Click any drug to see the details.

1 of the 3 ingredients in SynovX Al interact with drugs. Each result below shows which ingredient is responsible. Hesperidin

Each ingredient & the kinds of drugs it affects

For each ingredient in SynovX Al with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperidin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SynovX Al, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

SynovX Al by XYMOGEN: Common Questions

Does SynovX Al by XYMOGEN interact with any medications?
Yes. Based on its ingredients, SynovX Al has a known interaction with 702 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SynovX Al contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
The safety data we have on hesperidin isn't clear enough to know either way. Some evidence suggests it might be safe, but there isn't enough information to be sure. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing—they can help you decide what's right for your situation.
Does hesperidin actually help with weight loss or cholesterol?
Based on the evidence we have, hesperidin is rated possibly ineffective for both obesity and high cholesterol. It's not shown to work well for those goals. For fatty liver disease, we don't have enough reliable data to say either way.
What is hesperidin, and why is it in this product?
Hesperidin is a plant compound (flavonoid) believed to support joint and connective tissue health. That's why it's included in SynovX Al, though the evidence for some of its claimed benefits is limited.
Can I take this if I'm on a blood thinner like warfarin?
Hesperidin may increase your bleeding risk if combined with blood thinners or antiplatelet drugs. Don't start this product without checking with your doctor or pharmacist first—they can assess whether it's safe for you.
What are the inactive ingredients, and are there fillers?
The inactive ingredients include dicalcium phosphate, microcrystalline cellulose, ascorbyl palmitate, silica, medium-chain triglyceride oil, and the capsule. These are standard binders, fillers, and stabilizers found in most supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SynovX Al is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SynovX Al label
Go deeper

The Full Monographs Behind SynovX Al’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph →
Sources

Sources & How We Checked

SynovX Al's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team