Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Test-Up Ingredients & Drug Interactions

by MDLogic

Test-Up label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Test-Up against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Test-Up is a dietary supplement by MDLogic with 6 active ingredients. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 1,079 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Horny Goat Weed extract, ForsLean Coleus forskohlii root extract, Testofen Fenugreek extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Test-Up by MDLogic

Ask about any prescription or over-the-counter medication and we check it for interactions with Test-Up by MDLogic — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Test-Up by MDLogic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Testofen Fenugreek extract” is listed as a grouped ingredient — the label gives one combined amount (600 mg) without saying how much of each component you get.
  • “Horny Goat Weed extract” is listed as a grouped ingredient — the label gives one combined amount (225 mg) without saying how much of each component you get.
  • “ForsLean Coleus forskohlii root extract” is listed as a grouped ingredient — the label gives one combined amount (225 mg) without saying how much of each component you get.

Test-Up contains 6 active ingredients. The main ones are Testofen Fenugreek extract, Forskolin (from Coleus), Oatstraw extract, Tribulus terrestris powder, plus proprietary botanical blends including Horny Goat Weed extract and Fenuside.

These are herbal ingredients traditionally used to support testosterone and sexual function. The product also contains inactive ingredients — Hypromellose, Monolaurin, and Microcrystalline Cellulose — which are common capsule fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Oats) (Natural Medicines).
  • On file: Dyslipidemia — rated "Likely Effective" (Oats) (Natural Medicines).
  • On file: Sexual dysfunction — rated "Possibly Effective" (Tribulus) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Oats) (Natural Medicines).
  • On file: Gastric cancer — rated "Possibly Effective" (Oats) (Natural Medicines).

The evidence on Test-Up's ingredients is mixed. Oatstraw extract is rated Likely Effective for managing cholesterol (dyslipidemia) and heart disease.

Tribulus terrestris is rated Possibly Effective for sexual dysfunction. However, Forskolin has insufficient reliable evidence for the conditions it's studied in — angina, asthma, heart failure, eczema, and dry eye.

We don't hold effectiveness ratings for the other ingredients in the product.

The evidence, ingredient by ingredient Fenugreek Oats Horny Goat Weed Coleus Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Forskolin is generally well tolerated when taken by mouth, though some trial participants reported constipation, diarrhea, nausea, or vomiting. The data notes it may lower blood pressure and is not well studied long-term, so careful use and professional guidance are advised.

The safety data advises against Forskolin use during pregnancy and breastfeeding. Oatstraw extract is generally well tolerated and considered likely safe in pregnancy and breastfeeding when eaten as food; concentrated supplements are less studied.

You may experience bloating, flatulence, or mild gastrointestinal distention if you increase fiber intake too quickly — these usually fade with continued use. Tribulus terrestris is often well tolerated short-term but has limited long-term safety data.

Rare serious effects like liver and kidney injury or seizures have been reported. The safety data advises against Tribulus during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Fenugreek Oats Horny Goat Weed Coleus Tribulus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Tribulus, Oats, Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 986 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Stop and check with your pharmacist before taking Test-Up if you use any of these: nitrates or calcium channel blockers for your heart (Major severity), blood pressure medications, blood sugar medications or insulin, blood thinners or antiplatelet drugs, lithium, or any drug metabolized by your liver's CYP2C9 or CYP3A4 enzymes. These are Moderate-severity interactions that can reduce how well your medication works or increase side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Test-Up is designed to support testosterone and sexual function using herbal ingredients. It's not for you if you take nitrates, calcium channel blockers, blood pressure medications, blood sugar medications, insulin, lithium, or blood thinners — the interactions are serious enough to warrant a conversation first.

Even if you're on other medications, check them with your pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Test-Up, straight from the product label.

Brand MDLogic
Barcode (UPC) 897395002600
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 320650
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Seniors/Mature (>50 Years) - Men ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Test-Up by MDLogic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
897395002600
IngredientAmount% DV
Testofen Fenugreek extract600 mg--
Saponins189 mg--
Forskolin22.5 mg--
Oatstraw extract300 mg--
Fenuside300 mg--
Horny Goat Weed extract225 mg--
Flavonoids22.5 mg--
ForsLean Coleus forskohlii root extract225 mg--
Tribulus terrestris L. Extract472.5 mg--
Tribulus terrestris, Powder465 mg--

Other ingredients: Hypromellose, Monolaurin, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended use: As a dietary supplement, take 3 capsules daily (in divided dose) along with a healthy diet and exercise regimen, or as directed by a qualified health care professional. Intense training or men 50 years of age and over: Take 3 capsules twice daily.

Precautions

Warning: Consult with a health care professional before use and/or if you are pregnant, lactating, or undergoing treatment for a medical condition.

Do not exceed recommended dosage. Discontinue use if any adverse reactions occur and contact a health care professional. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA, This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in the USA from global ingredients Manufactured by a GMP Certified Company

Formulation

Gluten Free BPA Free

Testosterone Booster Increase libido Help build muscle Revitalize mind and body

Contains no milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, or shrimp), tree nuts, wheat, peanuts, soybean, or sesame. No artificial colors or flavors. No toxic fillers, including stearates and palmitates. Product contains no phthalates.

Lab tested for contaminants, including heavy metals and mold.

Brand IP Statement(s)

Supplementing Life MD Logic Est. 2005

Testofen is a registered trademark of Gencor Pacific Inc. Forslean is a registered trademark of Sabinsa Corporation and is the only Coleus forskohlii preparation supported by US Patent # 5,804,596

FDA Statement of Identity

Dietary Supplement

General Statements

Scan me!

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Test-Up by MDLogic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Test-Up label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Test-Up by MDLogic

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Testofen Fenugreek extract

Interacts with
389 drugs
600 mg per serving

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...

Testofen Fenugreek extract monograph & interactions
  • › Fenuside

Oatstraw extract

Interacts with
86 drugs
300 mg per serving

Oats are a well-studied whole grain whose soluble fiber (beta-glucan) can help lower cholesterol and support heart health when eaten regularly. As a f...

Oatstraw extract monograph & interactions

Horny Goat Weed extract

Interacts with
963 drugs
225 mg per serving

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed extract monograph & interactions
  • › Flavonoids

ForsLean Coleus forskohlii root extract

Interacts with
915 drugs
225 mg per serving

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

ForsLean Coleus forskohlii root extract monograph & interactions

Tribulus terrestris L. Extract

Interacts with
259 drugs
472.5 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris L. Extract monograph & interactions
  • › Saponins

Tribulus terrestris, Powder

Interacts with
259 drugs
465 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris, Powder monograph & interactions

Other (inactive) ingredients: Hypromellose, Monolaurin, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Test-Up by MDLogic Drug Interactions

Want to check YOUR meds against Test-Up?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,079Drugs
29 Major 1,050 Moderate

Ingredients driving the most interactions

Horny Goat Weed extract 963
ForsLean Coleus forskohlii root extract 915
Testofen Fenugreek extract 389
Tribulus terrestris L. Extract 259
Oatstraw extract 86

Individual Drug Interactions

The ingredients in Test-Up interact with 1,079 drugs. Click any drug to see the details.

5 of the 6 ingredients in Test-Up interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed extract ForsLean Coleus forskohlii root extract Testofen Fenugreek extract Tribulus terrestris L. Extract Oatstraw extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Test-Up with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed extract full monograph & interactions

ForsLean Coleus forskohlii root extract7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
ForsLean Coleus forskohlii root extract full monograph & interactions

Testofen Fenugreek extract9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Testofen Fenugreek extract full monograph & interactions

Tribulus terrestris L. Extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris L. Extract full monograph & interactions

Oatstraw extract2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.
Consuming oats can decrease blood glucose in patients with diabetes. In those who require insulin, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence D
Insulin

Concomitant use of oats and insulin might increase the risk of hypoglycemia.
In patients with insulin-dependent type 2 diabetes, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence B
Oatstraw extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Test-Up, from the product label.

MDLogic

See all MDLogic products
Name
MD Logic Health
State
Florida
Phone Number
1-877-629-8711
Web Address
www.mdlogichealth.com
Pharmacist Counseling Corner

Test-Up by MDLogic: Common Questions

Does Test-Up by MDLogic interact with any medications?
Yes. Based on its ingredients, Test-Up has a known interaction with 1,079 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Test-Up contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Test-Up if I'm on blood pressure medication?
Not without checking first. Both Forskolin and Tribulus in this product can lower blood pressure, and combining them with your medication raises the risk of blood pressure dropping too low. Talk to your pharmacist about your specific blood pressure drug before starting.
Can I take Test-Up if I have diabetes or take insulin?
Not without checking first. Oatstraw and Tribulus in this product can lower blood sugar. If you're on insulin or diabetes medications, combining them with Test-Up increases your risk of low blood sugar (hypoglycemia). Check with your pharmacist or doctor first.
Is Test-Up safe to use while pregnant or breastfeeding?
No. The safety data advises against Forskolin and Tribulus during pregnancy and breastfeeding — there isn't enough data to know they're safe. Talk with your doctor or pharmacist about whether this product is right for you in these situations.
What side effects might I get from Test-Up?
Gastrointestinal side effects are most common — constipation, diarrhea, nausea, or vomiting from the Forskolin, or bloating and flatulence from the Oatstraw (especially if you increase fiber intake quickly). Rare serious effects like liver or kidney injury have been reported with Tribulus, though they're uncommon.
Does Test-Up actually work for sexual dysfunction?
Tribulus terrestris in this product is rated Possibly Effective for sexual dysfunction, meaning some evidence supports it, but it's not definitive. The other ingredients don't have solid effectiveness ratings in our data. Results vary by person.
What ingredients in Test-Up couldn't be checked for drug interactions?
We hold no interaction data for Saponins, Fenuside, or Flavonoids, so we can't tell you how they might affect your medications. That doesn't mean they don't interact — just that we don't have the information. Your pharmacist can help research these if you need it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Test-Up is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Test-Up label
Go deeper

The Full Monographs Behind Test-Up’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Oats

Interacts with 86 drugs

Oats are a well-studied whole grain whose soluble fiber (beta-glucan) can help lower cholesterol and support heart health when eaten regularly. As a food, oats are safe for most people, and...

Read the full Oats monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Test-Up's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fenugreek 30 references
  1. Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
  2. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
  3. Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
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Coleus 16 references
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Oats 13 references
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Horny Goat Weed 11 references
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Tribulus 10 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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