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Dietary supplement

Turkey Tail Ingredients & Drug Interactions

by Tonic Tinctures

Turkey Tail label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Turkey Tail against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Turkey Tail is a dietary supplement by Tonic Tinctures with 1 active ingredient. Its ingredients are commonly taken for immune support, used alongside cancer care, gut and digestive health.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Turkey Tail Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Turkey Tail by Tonic Tinctures

Ask about any prescription or over-the-counter medication and we check it for interactions with Turkey Tail by Tonic Tinctures — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Turkey Tail by Tonic Tinctures

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Turkey Tail Mushroom, a fungus with a long history in traditional medicine. The liquid form is suspended in distilled water and alcohol (the carrier that extracts and preserves the mushroom's active compounds).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Turkey Tail Mushroom's overall clinical evidence instead.

Moderate

Some clinical evidence supports Turkey Tail Mushroom for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cancer — rated "Possibly Effective" (Natural Medicines).

Turkey Tail Mushroom is considered possibly effective for cancer based on the evidence we have on file. For chronic fatigue syndrome, tinea corporis (ringworm), upper respiratory tract infections, and genital herpes, there isn't enough reliable evidence yet to say whether it works.

The evidence, ingredient by ingredient Turkey Tail Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Turkey Tail is generally well tolerated in healthy adults, though quality and strength of supplements vary—so it's wise to check with your doctor or pharmacist before you start. The safety data during pregnancy and breastfeeding isn't established, so the safety information we have advises against use in both situations.

When PSK (a turkey tail component) has been studied alongside chemotherapy, some people reported nausea, vomiting, appetite loss, stomach upset, diarrhea, constipation, or ulcers, but it's unclear whether these came from the mushroom, the chemotherapy, or both.

Side effects, ingredient by ingredient Turkey Tail Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Turkey Tail Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Turkey Tail, double-check with your doctor or pharmacist if you're on cyclophosphamide (a chemotherapy drug), antidiabetes medications, tamoxifen, or any drugs processed through the CYP2C9 enzyme pathway. These are the medication types with documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Turkey Tail may be worth considering if you're interested in immune support and have discussed it with your doctor—especially if you're dealing with cancer or want to explore options for upper respiratory health. Steer clear if you take cyclophosphamide, tamoxifen, antidiabetes drugs, or medications metabolized by CYP2C9 without first checking in with your own doctor or pharmacist.

Avoid during pregnancy and breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Turkey Tail, straight from the product label.

Brand Tonic Tinctures
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259512
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Turkey Tail by Tonic Tinctures, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Dropper(s)
Maximum serving Sizes:
3 Dropper(s)
Servings per container
60
IngredientAmount% DV
Turkey Tail Mushroom0 NP--

Other ingredients: distilled Water, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Artisan liquid extract 1 dropper is approximately equal to 1250 mgs

Gluten free, no hidden additives

Suggested/Recommended/Usage/Directions

Shake gently before use

Directions: Use as directed, 1-3 droppers 1-3 times a day. Use within 45 days of opening

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

FDA Disclaimer Statement

Caution: These products are not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Turkey Tail by Tonic Tinctures label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Turkey Tail label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Turkey Tail by Tonic Tinctures

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Dropper(s) Dosage formLiquid Servings per container60 Amounts shown are per serving.

Turkey Tail Mushroom

Interacts with
187 drugs
0 NP per serving Form: Coriolus versicolor, Coriolus versicolor, Coriolus versicolor

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified...

Turkey Tail Mushroom monograph & interactions

Other (inactive) ingredients: Distilled Water, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Turkey Tail by Tonic Tinctures Drug Interactions

Want to check YOUR meds against Turkey Tail?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
88 Moderate 99 Minor

Ingredients driving the most interactions

Turkey Tail Mushroom 187

Individual Drug Interactions

The ingredients in Turkey Tail interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Turkey Tail interact with drugs. Each result below shows which ingredient is responsible. Turkey Tail Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Turkey Tail with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Turkey Tail Mushroom4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Turkey Tail Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Turkey Tail, from the product label.

Tonic Tinctures

See all Tonic Tinctures products
Name
Tonic Apothecary
Web Address
www.tonictinctures.com
Pharmacist Counseling Corner

Turkey Tail by Tonic Tinctures: Common Questions

Does Turkey Tail by Tonic Tinctures interact with any medications?
Yes. Based on its ingredients, Turkey Tail has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Turkey Tail contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Turkey Tail safe if I'm pregnant or breastfeeding?
Not enough safety data exists for pregnancy or breastfeeding, so the information we have advises against use in both. Talk with your doctor or pharmacist about whether this product is right for you in these situations.
What does Turkey Tail actually do?
Turkey Tail is considered possibly effective for cancer. For other conditions—chronic fatigue, ringworm, respiratory infections, and genital herpes—there isn't yet enough reliable evidence to say whether it works.
Can I take Turkey Tail if I'm on chemotherapy?
Not without talking to your oncologist first. Turkey Tail may alter how cyclophosphamide and possibly other chemotherapy drugs work in your body, which could be risky.
What are the side effects?
Turkey Tail is generally well tolerated. When its active component (PSK) was studied alongside chemotherapy, some people reported nausea, vomiting, loss of appetite, stomach upset, diarrhea, constipation, or ulcers—but it's unclear whether the mushroom, the chemotherapy, or both caused these.
Can I take this with my blood sugar medication?
Turkey Tail may lower blood sugar, so combining it with antidiabetes drugs could increase the risk of low blood sugar (hypoglycemia). Check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Turkey Tail label
Go deeper

The Full Monographs Behind Turkey Tail’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph →
Sources

Sources & How We Checked

Turkey Tail's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Turkey Tail Mushroom 15 references
  1. Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
  2. Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
  3. Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
  4. Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
  5. Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
  6. Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
  7. Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
  8. Yeung JH and Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 2011;18(13):1170-5. PubMed
  9. Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov 2012;6(1):78-87. PubMed
  10. Chan SL, Yeung JH. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem Toxicol 2006;44:689-94. PubMed
  11. Serrano L, López AC, González SP, et al. Efficacy of a Coriolus versicolor-based vaginal gel in women with human papillomavirus-dependent cervical lesions: The PALOMA study. J Low Genit Tract Dis 2021;25(2):130-136. PubMed
  12. Meng F, Lin Y, Hu L, Feng W, Su P, Wu L. The therapeutic effect of Coriolus versicolor fruiting body on STZ-induced ICR diabetic mice. J Healthc Eng 2022;2022:7282453. PubMed
  13. Razmovski-Naumovski V, Kimble B, Laurenti D, Nammi S, Norimoto H, Chan K. Polysaccharide peptide extract from Coriolus versicolor increased T(max) of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in t
  14. Cortés Bordoy J, de Santiago García J, Agenjo González M, et al. Effect of a multi-ingredient Coriolus-versicolor-based vaginal gel in women with HPV-dependent cervical lesions: The papilobs real-life prospective study. Cancers (Basel) 2023;15(15):3863. PubMed
  15. Nikolic M, Lazarevic N, Novakovic J, et al. Characterization, in vitro biological activity and in vivo cardioprotective properties of Trametes versicolor (L.:Fr.) quél. heteropolysaccharides in a rat model of metabolic syndrome. Pharmaceuticals (Basel) 20 PubMed

See these in context on the Turkey Tail Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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