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Dietary supplement

Uva Ursi Ingredients & Drug Interactions

by Puritan's Pride

Uva Ursi label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva Ursi by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva Ursi by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Uva Ursi by Puritan's Pride contains one active ingredient: uva ursi leaf extract, a plant traditionally used for urinary tract support. The capsule itself is made from gelatin as an inactive ingredient.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract health.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, kidney health, diuretic support.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for uva ursi's effectiveness is mixed and limited. For urinary tract infections (UTIs), it's rated possibly ineffective based on available data.

For bronchitis and benign prostatic hyperplasia (enlarged prostate), the evidence is insufficient—we simply don't have enough reliable studies to know either way. If you're considering this for a specific condition, it's worth discussing with your doctor what the current evidence shows and whether it's the right choice for you.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated at low doses when used short-term. The most common side effects are mild—diarrhea, nausea, stomach upset, and vomiting.

At very high doses (20 grams or more of the dried herb), serious effects like convulsions, delirium, shortness of breath, and tingling in the ears have been reported, and doses of 30 grams or more may be fatal. Pregnancy: the safety data advises against it—uva ursi may stimulate the uterus and lacks safety information.

Breastfeeding: there isn't enough safety information available, so talk with your doctor or pharmacist for personalized advice before taking it while nursing.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you use any drugs metabolized by CYP2C19 or CYP3A4 liver enzymes (this includes many blood pressure, cholesterol, and immunosuppressant medications), drugs cleared by glucuronidation, lithium, urinary acidifying agents, or P-glycoprotein substrates. Because uva ursi may slow how your body clears these drugs, your doses may need adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi may be worth considering if you're looking for short-term urinary tract support, but be aware that evidence for UTIs is weak and evidence for other uses is too limited to draw firm conclusions. The main caution is drug interactions—it may slow how your liver and kidneys clear several hundred common medications.

If you take any prescription drugs, especially for blood pressure, cholesterol, mood, or immune function, or if you take lithium, check your medications with your pharmacist before starting. Pregnancy and breastfeeding require a conversation with your doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 074312109317
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 2951
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
33
UPC/BARCODE
074312109317
IngredientAmount% DV
Uva Ursi1500 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

To reorder call 1-800-645-1030 or order on the web www.puritan.com

Puritan's Pride Guarantee: We only use the finest quality herbs and spices. Each is screened and finely milled for quick release.

Puritan's Pride preservative free gelatin capsules contain 100% pure milled herb powder.

Uva Ursi, also known as bearberry, is an herb entrenched with folk tradition. Today, Uva Ursi is particularly popular among women, but widely used by both men and women.

Brand IP Statement(s)

Inspired by Nature

Puritan's Pride, Inc., 1999

FDA Statement of Identity

Herbal Supplement

Precautions

Pregnant or lactating women should consult a doctor before using any product.

Not intended for use by persons under the age of 18

Consult doctor before use if you have or had: kidney/urologic disease or gastrointestinal disorders.

Discontinue use and consult a doctor if adverse reactions occur. This product is not recommended for long term daily usage.

Keep out of reach of children

Tamper Resistant: Do not use if imprinted seal under cap is broken

Formulation

Guaranteed Free Of: Yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium (less than 5mg per serving).

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) to three (3) capsules three times daily, or as desired at mealtimes with a full glass of water.

Storage

Store in a cool, dry place

General

Prod. No. 931 B931 01B

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.

Uva Ursi

Interacts with
803 drugs
1500 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi by Puritan's Pride Drug Interactions

Want to check YOUR meds against Uva Ursi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Uva Ursi 803

Individual Drug Interactions

The ingredients in Uva Ursi interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva Ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Oakdale
State
NY
ZipCode
11769
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Uva Ursi by Puritan's Pride: Common Questions

Does Uva Ursi by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Uva Ursi has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take uva ursi while pregnant or breastfeeding?
During pregnancy, the safety data advises against it—uva ursi may stimulate the uterus and lacks safety information. While breastfeeding, there isn't enough data to know either way, so talk with your doctor or pharmacist before taking it.
What are the most common side effects?
At normal doses, uva ursi is generally well tolerated. The most common side effects are mild: diarrhea, nausea, stomach upset, and vomiting. These usually happen because it can irritate your digestive tract.
Does uva ursi actually work for urinary tract infections?
The evidence suggests it's possibly ineffective for UTIs based on available data. For other uses like bronchitis or enlarged prostate, we don't have enough reliable research to know whether it works.
How long can I safely take uva ursi?
Uva ursi is meant to be used short-term only. At high doses or with prolonged use, it can become toxic. Stick to the dosing instructions on the label and don't use it long-term without talking to your pharmacist.
Why do I need to check my medications before taking this?
Uva ursi may slow how your liver and kidneys clear certain drugs, potentially raising their levels in your blood and increasing side effects or risks. This is especially important for blood pressure medications, cholesterol drugs, lithium, and immunosuppressants.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi label
Go deeper

The Full Monographs Behind Uva Ursi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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