Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Vein Complex Ingredients & Drug Interactions

by Integrative Therapeutics

Vein Complex label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vein Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vein Complex is a dietary supplement by Integrative Therapeutics with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 893 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Gotu Kola (Centella asiatica) leaf Phytosome, Calcium, Butcher's Broom (Ruscus aculeatus) root and rhizome extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vein Complex by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Vein Complex by Integrative Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vein Complex by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Vein Complex contains four active ingredients, each chosen for circulatory or venous support. Calcium is included for bone and metabolic health.

Butcher's broom root extract and horse chestnut seed extract are traditional botanicals used for chronic venous insufficiency — the condition of weak or damaged veins, usually in the legs. Gotu kola leaf is included in a concentrated phytosome form, which is a plant extract bound to phospholipids to improve absorption.

The tablet also contains inactive ingredients (cellulose, modified cellulose gum, magnesium stearate, and carnauba wax) that serve as binders, fillers, and coating.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support leg vein health.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Hemorrhoids, Venous insufficiency, leg swelling, circulation.
  • The strongest evidence on file: Butcher's Broom is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Gotu Kola is rated "Possibly Effective" for Venous insufficiency.
  • Also on file: Horse Chestnut is rated "Possibly Effective" for Chronic venous insufficiency (CVI).

Calcium is effective for several conditions: it's been shown to help with kidney failure, indigestion, low blood calcium (hypocalcemia), high potassium levels (hyperkalemia), and is likely effective for osteoporosis. Butcher's broom and horse chestnut are both rated possibly effective for chronic venous insufficiency, though the evidence is limited.

Gotu kola is rated possibly effective for venous insufficiency and burns, but possibly ineffective for radiation dermatitis and cognitive function. For other uses listed in the ingredient data — such as hemorrhoids, lymphedema, and other conditions — the evidence is either insufficient or not established in our data.

The evidence, ingredient by ingredient Calcium Butcher's Broom Horse Chestnut Gotu Kola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated when taken at recommended doses, though high amounts can cause problems. Common side effects from oral calcium include belching, constipation, diarrhea, bloating, and stomach upset.

Rare serious concerns include kidney stones and a skin condition called calciphylaxis. Some research suggests very high calcium intake — over 1,500–2,000 mg daily — may be linked to increased prostate cancer risk and possibly heart disease, though the evidence is mixed and debated.

Butcher's broom is generally well tolerated short-term but long-term safety data are limited; common side effects include diarrhea, indigestion, heartburn, nausea, and vomiting. Horse chestnut seed extract (when processed to remove toxic parts) is generally tolerated; side effects may include dizziness, stomach upset, headache, and itching.

Gotu kola is generally well tolerated but case reports have raised concerns about liver toxicity, though a clinical trial at 120 mg daily for 6 months showed no liver damage. Gotu kola may cause stomach irritation, nausea, or skin reactions.

Side effects, ingredient by ingredient Calcium Butcher's Broom Horse Chestnut Gotu Kola

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Butcher's Broom, Gotu Kola, Calcium, Horse Chestnut.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 894 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your exact medications against these drug types, in order of seriousness: HIV integrase inhibitors (dolutegravir, elvitegravir), the antibiotic ceftriaxone if given intravenously, blood thinners and antiplatelet drugs, thyroid hormone (levothyroxine), heart medications (diltiazem, sotalol, raltegravir), medications that work on alpha-adrenergic receptors, central nervous system depressants (sleep aids, anxiety meds, opioids), and drugs that can damage the liver. Use the checker below to look up your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Vein Complex may be worth considering if you're looking for support with chronic venous insufficiency, but calcium and the three botanical ingredients carry several medication interactions you need to check first — especially if you take any HIV drugs, thyroid medication, blood thinners, or heart medications. If you take any prescription drugs at all, run them through the tool on this page before you start.

Talk to your pharmacist if you're pregnant, breastfeeding, or have liver or kidney concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vein Complex, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791002203
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 78156
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vein Complex by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
45
UPC/BARCODE
871791002203
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Calcium140 mg14%
Butcher's Broom (Ruscus aculeatus) root and rhizome extract300 mg--
Horse Chestnut (Aesculus hippocastanum) seed extract250 mg--
Gotu Kola (Centella asiatica) leaf Phytosome30 mg--

Other ingredients: Cellulose, modified Cellulose Gum, Modified Cellulose, Magnesium Stearate, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vein Complex contains herbs traditionally used to support the health of leg veins.* The proprietary Phytosome technology, which combines one part standardized gotu kola extract with two parts phosphatidylcholine, improves bioavailability.*

Suggested/Recommended/Usage/Directions

Recommendations: Take 2 tablets twice daily, or as recommended by your healthcare professional.

Precautions

If pregnant, nursing, or taking prescription drugs, consult your healthcare professional prior to use.

Formulation

Contains no sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, preservatives, or ingredients of animal origin.

Brand IP Statement(s)

2014 Integrative Therapeutics, LLC

General

LZ78849.B01

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Vein support

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vein Complex by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vein Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vein Complex by Integrative Therapeutics

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
140 mg per serving Form: Calcium Carbonate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Butcher's Broom (Ruscus aculeatus) root and rhizome extract

Interacts with
158 drugs
300 mg per serving Form: Saponins

Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence sug...

Butcher's Broom (Ruscus aculeatus) root and rhizome extract monograph & interactions

Horse Chestnut (Aesculus hippocastanum) seed extract

Interacts with
122 drugs
250 mg per serving Form: Triterpene Glycosides

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horse Chestnut (Aesculus hippocastanum) seed extract monograph & interactions

Gotu Kola (Centella asiatica) leaf Phytosome

Interacts with
579 drugs
30 mg per serving Form: Gotu Kola extract

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Gotu Kola (Centella asiatica) leaf Phytosome monograph & interactions

Other (inactive) ingredients: Cellulose, Modified Cellulose Gum, Modified Cellulose, Magnesium Stearate, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vein Complex by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Vein Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
893Drugs
7 Major 869 Moderate 17 Minor

Ingredients driving the most interactions

Gotu Kola (Centella asiatica) leaf Phytosome 579
Calcium 168
Butcher's Broom (Ruscus aculeatus) root and rhizome extract 158
Horse Chestnut (Aesculus hippocastanum) seed extract 122

Individual Drug Interactions

The ingredients in Vein Complex interact with 893 drugs. Click any drug to see the details.

4 of the 4 ingredients in Vein Complex interact with drugs. Each result below shows which ingredient is responsible. Gotu Kola (Centella asiatica) leaf Phytosome Calcium Butcher's Broom (Ruscus aculeatus) root and rhizome extract Horse Chestnut (Aesculus hippocastanum) seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Vein Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gotu Kola (Centella asiatica) leaf Phytosome2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Gotu Kola (Centella asiatica) leaf Phytosome full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Butcher's Broom (Ruscus aculeatus) root and rhizome extract2 drug types · 158 drugs

Alpha-Adrenergic Agonists

Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.

Likelihood Possible Evidence D
Alpha-Adrenergic Antagonists

Theoretically, butcher's broom might reduce the effects of alpha-adrenergic antagonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.

Likelihood Possible Evidence D
Butcher's Broom (Ruscus aculeatus) root and rhizome extract full monograph & interactions

Horse Chestnut (Aesculus hippocastanum) seed extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut (Aesculus hippocastanum) seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vein Complex, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800.931.1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Vein Complex by Integrative Therapeutics: Common Questions

Does Vein Complex by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Vein Complex has a known interaction with 893 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vein Complex contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on levothyroxine for my thyroid?
Calcium in this product reduces how well your body absorbs levothyroxine, which could weaken its effect. If you take levothyroxine, separate it from this supplement by at least 4 hours — don't take them together. Run levothyroxine through the interaction tool to confirm the timing with your dose.
What is gotu kola leaf phytosome, and is it different from regular gotu kola?
Gotu kola leaf phytosome is the gotu kola extract bound to phospholipids — a form designed to improve how your body absorbs it. The ingredient and its interactions remain the same, just in a more absorbable format.
Is this product safe for long-term use?
Calcium is generally safe long-term at recommended doses, but butcher's broom and gotu kola have limited long-term safety data. Gotu kola in particular has some case reports of liver problems, though a clinical trial showed no liver damage at 120 mg daily. Talk with your pharmacist about how long you plan to take it.
What does butcher's broom do in this product?
Butcher's broom extract is used for chronic venous insufficiency — a condition of weak or damaged veins, usually in the legs. The evidence suggests it's possibly effective, though more research is needed.
Will this cause constipation?
Calcium commonly causes constipation and bloating in some people, along with diarrhea and stomach upset in others. If constipation is a concern, talk with your pharmacist about whether this product is right for you or if you need added fiber or hydration support.
Can I take this while pregnant?
Calcium alone is likely safe in pregnancy if you stay within recommended amounts. However, horse chestnut is unsafe in pregnancy and should be avoided, and butcher's broom and gotu kola don't have enough safety data — avoid them. Talk with your doctor before taking this product while pregnant.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vein Complex label
Go deeper

The Full Monographs Behind Vein Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Butcher's Broom

Interacts with 158 drugs

Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence suggests it may help reduce swelling and di...

Read the full Butcher's Broom monograph → Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph → Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph →
Sources

Sources & How We Checked

Vein Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
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Gotu Kola 18 references
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