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Dietary supplement

Vitamin D3 5,000 IU Ingredients & Drug Interactions

by Genesis Today

Vitamin D3 5,000 IU label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin D3 5,000 IU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitamin D3 5,000 IU is a dietary supplement by Genesis Today with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 1,080 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BioPerine Black Pepper (Piper nigrum) extract, Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vitamin D3 5,000 IU by Genesis Today

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin D3 5,000 IU by Genesis Today — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Vitamin D3 5,000 IU by Genesis Today

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Vitamin D3 is the main component at 5,000 IU per softgel — it's the active form of vitamin D your body uses to regulate calcium, support bone health, and maintain immune function.

The second ingredient is BioPerine Black Pepper extract, a concentrated form of black pepper that contains piperine, often added to supplements to enhance absorption of other ingredients. The softgel also contains inactive ingredients: organic flax seed oil, D-alpha-tocopherol (a form of vitamin E), and the vegetarian soft gel capsule itself.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports calcium absorption and bone health.
  • We looked for evidence on: Corticosteroid-induced osteoporosis, Fall prevention, Fractures, Hyperparathyroidism-related bone loss, Kidney transplant-related bone loss, Osteomalacia — and 3 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Osteomalacia (Natural Medicines).
  • Also on file: Vitamin D is rated "Effective" for Vitamin D deficiency.
  • Also on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis.

Vitamin D3 is effective for treating specific medical conditions: familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease from kidney failure), rickets, and hypoparathyroidism. If you're taking this for one of those diagnosed conditions under your doctor's care, the evidence supports its use.

For black pepper extract, the evidence isn't established. Our data shows insufficient reliable evidence to rate it for allergic rhinitis, asthma, athletic performance, headache, depression, or diarrhea.

It's included here mainly as a bioavailability enhancer for the vitamin D, not as a standalone active ingredient for those purposes.

The evidence, ingredient by ingredient Vitamin D Black Pepper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 at recommended doses is generally well tolerated. Very high doses over time can cause toxicity with symptoms of high blood calcium (hypercalcemia), including excessive thirst, nausea, kidney problems, and in rare cases, eye inflammation or decreased growth in children.

This product is 5,000 IU daily — above the recommended dietary allowance but within ranges often used under medical supervision; stay alert to any signs of toxicity if you take it long-term. Black pepper extract at food-level amounts is safe, but concentrated supplements warrant more caution.

The most common side effects are burning aftertaste, indigestion, and reduced taste perception. Allergic reactions are rare but possible.

During pregnancy and breastfeeding, normal food amounts of black pepper are fine, but the safety of supplement-strength piperine hasn't been well studied — talk to your doctor. Vitamin D is often used in pregnancy at recommended doses, but only under your doctor's guidance.

Side effects, ingredient by ingredient Vitamin D Black Pepper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Pepper, Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,081 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use heart rhythm medications (digoxin, verapamil, diltiazem), thiazide diuretics (water pills), atorvastatin (cholesterol), propranolol (heart/blood pressure), phenytoin (seizures), theophylline (breathing), rifampin (infection), nevirapine (HIV), cyclosporine (immunosuppressant), or pentobarbital (sedative). These represent the Moderate-severity interactions with vitamin D3 and the black pepper extract.

The black pepper component can meaningfully raise blood levels of several of these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people with diagnosed vitamin D deficiency or specific bone and calcium disorders where vitamin D is medically appropriate. If you take medications for heart rhythm, blood pressure, cholesterol, seizures, HIV, tuberculosis, or immunosuppression, you need to check your exact drugs with the tool on this page before starting.

Talk to your pharmacist — the black pepper extract can significantly change blood levels of several common medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin D3 5,000 IU, straight from the product label.

Brand Genesis Today
Barcode (UPC) 812711013084
Net contents 60 Vegetarian Softgel(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34084
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin D3 5,000 IU by Genesis Today, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel Capsule(s)
Maximum serving Sizes:
2 Softgel Capsule(s)
Servings per container
30
UPC/BARCODE
812711013084
IngredientAmount% DV
Vitamin D35000 IU1250%
BioPerine Black Pepper (Piper nigrum) extract10 mg--

Other ingredients: organic Flax Seed Oil, D-Alpha-Tocopherol, Vegetarian Soft Gel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two (2) capsules once a day or as recommended by your healthcare provider.

General Statements

Enjoy and live long!

Supports Calcium Absorption

Plant-Derived

Supports: HEALTHY BONES

Precautions

Caution: Excessive supplementation can lead to toxicity. More than one dose a day can cause side effects or toxicity. Do not use if seal around cap is broken.

Keep out of reach of children.

Storage

Store at room temperature and avoid excessive heat. Do not freeze or refrigerate.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

LBGT144

Formulation

Vegetarian Vitamin D3 Support

The Vitamin D3 (cholecalciferol) used in this product is Vitashine, a proprietary standardized source of vegetarian Vitamin D3 from ESB Developments.

Brand IP Statement(s)

BioPerine(R) is a registered trademark of Sabinsa.

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

V CONTAINS VITASHINE D3

BioPerine(R)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin D3 5,000 IU by Genesis Today label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin D3 5,000 IU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin D3 5,000 IU by Genesis Today

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
5000 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

BioPerine Black Pepper (Piper nigrum) extract

Interacts with
1,019 drugs
10 mg per serving Form: Piperine

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

BioPerine Black Pepper (Piper nigrum) extract monograph & interactions

Other (inactive) ingredients: Organic Flax Seed Oil, D-Alpha-Tocopherol, Vegetarian Soft Gel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin D3 5,000 IU by Genesis Today Drug Interactions

Want to check YOUR meds against Vitamin D3 5,000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,080Drugs
1,037 Moderate 43 Minor

Ingredients driving the most interactions

BioPerine Black Pepper (Piper nigrum) extract 1,019
Vitamin D3 715

Individual Drug Interactions

The ingredients in Vitamin D3 5,000 IU interact with 1,080 drugs. Click any drug to see the details.

2 of the 2 ingredients in Vitamin D3 5,000 IU interact with drugs. Each result below shows which ingredient is responsible. BioPerine Black Pepper (Piper nigrum) extract Vitamin D3

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin D3 5,000 IU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

BioPerine Black Pepper (Piper nigrum) extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
BioPerine Black Pepper (Piper nigrum) extract full monograph & interactions

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin D3 5,000 IU, from the product label.

Genesis Today

See all Genesis Today products
Name
Genesis Today, Inc.
Street Address
14101 W. Highway 290, Bldg. #1900
City
Austin
State
TX
ZipCode
78737
Phone Number
(800) 916-6642
Web Address
www.genesistoday.com
Pharmacist Counseling Corner

Vitamin D3 5,000 IU by Genesis Today: Common Questions

Does Vitamin D3 5,000 IU by Genesis Today interact with any medications?
Yes. Based on its ingredients, Vitamin D3 5,000 IU has a known interaction with 1,080 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin D3 5,000 IU contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 5,000 IU of vitamin D3 a safe daily dose?
At 5,000 IU daily, you're above the standard recommended dietary allowance but within ranges used under medical supervision. Vitamin D is well tolerated at recommended doses, but very high doses over time can cause toxicity. If you're taking this long-term, mention it to your doctor so they can monitor you.
What does the black pepper extract do in this supplement?
BioPerine black pepper extract is included to help your body absorb the vitamin D3 better. Piperine, the active compound in black pepper, enhances bioavailability — but it also interacts with several medications, so it's important to check your drug list before taking this product.
Can I take this if I'm pregnant or breastfeeding?
Vitamin D is often used during pregnancy at recommended amounts, but only under your doctor's guidance — they'll personalize the dose for you. Black pepper at normal food levels is fine, but the safety of supplement-strength piperine during pregnancy and breastfeeding hasn't been well studied, so check with your doctor first.
What are the signs that I'm taking too much vitamin D?
Vitamin D toxicity causes high blood calcium symptoms: excessive thirst, nausea, vomiting, constipation, loss of appetite, and weakness. In rare cases, you may also notice eye inflammation or blurred vision. If you experience these, stop taking it and call your doctor right away.
Will this interact with my cholesterol medication?
Yes — if you take atorvastatin (Lipitor), both the vitamin D and the black pepper extract in this product can affect it. Vitamin D might reduce its absorption, and black pepper might increase blood levels. You need to check with your pharmacist about your specific medication and dosing.
What side effects might I experience from the black pepper extract?
Most people tolerate it well, but a burning aftertaste, indigestion, and reduced taste perception are the most common side effects. Allergic reactions are rare. If you're sensitive to peppers or have had reactions before, mention that to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin D3 5,000 IU label
Go deeper

The Full Monographs Behind Vitamin D3 5,000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph →
Sources

Sources & How We Checked

Vitamin D3 5,000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 55 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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