Whole Hemp Plant Extract Full Spectrum Ingredients & Drug Interactions
by HempWorx
What is this page for?
First and foremost: checking Whole Hemp Plant Extract Full Spectrum against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Whole Hemp Plant Extract Full Spectrum is a dietary supplement by HempWorx with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Whole Plant Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Whole Hemp Plant Extract Full Spectrum by HempWorx
Ask about any prescription or over-the-counter medication and we check it for interactions with Whole Hemp Plant Extract Full Spectrum by HempWorx — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Whole Hemp Plant Extract Full Spectrum by HempWorx
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: hemp whole plant extract, which is a concentrate of the entire hemp plant. It's presented as a liquid, so you're getting the full spectrum of compounds the plant contains—not just isolated parts.
There are no other inactive ingredients listed.
Does it work?
Couldn't assess
The evidence on hemp extract for the uses we have data for—constipation, eczema (atopic dermatitis), and high cholesterol (familial hypercholesterolemia)—is insufficient to rate. That means the studies so far aren't solid enough to say whether it works for these conditions.
We simply don't hold established effectiveness data for this product.
How safe is it?
Well-documented data
Hemp seed foods in normal amounts are generally well tolerated, but this is a concentrated extract, and concentrated hemp supplements are much less studied. The safety notes in our data advise caution with concentrated forms like this one.
In rare cases, people have reported allergic reactions including anaphylaxis (a severe, whole-body reaction), hives, facial swelling, and breathing trouble. There's also a rare case report of liver inflammation in a young child given high doses of hemp extract.
Most people tolerate hemp seed oil without problems, but because this is an extract rather than food, you're in less-charted territory.
Meds to double-check
Moderate interaction found
Before you take this product, double-check with your pharmacist if you're on any of these: hormone therapy or birth control (estrogens); blood pressure medications, including ACE inhibitors; blood thinners like warfarin or clopidogrel; or any drugs your liver processes through CYP1A2 or CYP3A4 enzymes—a category that includes a wide range of common medications. Hemp may interfere with how these work.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product might be worth considering if you're interested in hemp's potential, but go in with realistic expectations—the evidence for what it does isn't established yet. If you take any medications, especially for blood pressure, hormones, or blood clotting, check with your pharmacist or doctor before starting.
Concentrated extracts like this one aren't as well studied as food amounts of hemp seed, so caution is the smart move.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Whole Hemp Plant Extract Full Spectrum, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Whole Hemp Plant Extract Full Spectrum by HempWorx, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hemp Whole Plant Extract | 100 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Proprietary extraction process
Full spectrum dropper Water compatible
Precautions
Warning: If pregnant or nursing, consult your physician before using this product. Consuming this product during pregnancy exposes your child to delta-9-THC, which can affect your child's behavior and learning ability. For more information go to www.P65Warnings.ca.gov/cannabis.
For more information go to www.P65Warnings.ca.gov/cannabis.
Keep out of reach of children
General Statements
Approximately 100 drops 100 drops = 50 doses
Formula
Contains less than 0.3% of THC
FDA Disclaimer Statement
This product has not been evaluated by the Food and Drug Administration. These statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
GMP Good Manufacturing Practice
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Place two drops on the tongue and swallow, or add to your favorite beverage. Shake well before use
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Whole Hemp Plant Extract Full Spectrum by HempWorx label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Whole Hemp Plant Extract Full Spectrum by HempWorx
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.1 mL Dosage formLiquid Servings per container50 Amounts shown are per serving.
Hemp Whole Plant Extract
Interacts with938 drugs
Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...
Hemp Whole Plant Extract monograph & interactionsWhole Hemp Plant Extract Full Spectrum by HempWorx Drug Interactions
HelloPharmacist Interaction Report
HempWorx Whole Hemp Plant Extract Full Spectrum contains a single active ingredient—hemp whole plant extract—that interacts with several medication types.
The most serious concern is with hormone therapies like estrogens (birth control, hormone replacement). Hemp may interfere with how your body processes these hormones, though the exact mechanism isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
Hemp also interacts with blood pressure medications (antihypertensives and ACE inhibitors), blood thinners (anticoagulants and antiplatelet drugs), and certain other drugs your liver processes. These are all Minor to Moderate interactions—hemp might make blood pressure medications work harder or slightly increase bleeding risk, but human data is limited.
Your liver also breaks down many common medications through two enzyme systems (CYP1A2 and CYP3A4), and hemp may speed up that process, potentially reducing how well those drugs work.
Although the science here is mostly from animal studies or lab work rather than people taking this extract, these interactions are real enough that you should check your exact medications before starting. Altogether, these interactions span 927 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Whole Hemp Plant Extract Full Spectrum?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Whole Hemp Plant Extract Full Spectrum interact with 938 drugs. Click any drug to see the details.
1 of the 1 ingredient in Whole Hemp Plant Extract Full Spectrum interact with drugs. Each result below shows which ingredient is responsible. Hemp Whole Plant Extract
Bazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Conjugated Estrogens, Methyltestosterone interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Desogestrel, Ethinyl Estradiol interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Whole Plant Extract + Drospirenone, Ethinyl Estradiol interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Whole Plant Extract + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with Whole Hemp Plant Extract Full Spectrum — through 1 ingredient. Tap an ingredient for the detail:
Hemp Whole Plant ExtractEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Whole Plant Extract + Ethinyl Estradiol, Levonogestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Whole Hemp Plant Extract Full Spectrum with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Hemp Whole Plant Extract
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for Whole Hemp Plant Extract Full Spectrum, from the product label.
HempWorx
See all HempWorx products- Name
- MyDailyChoice, Inc.
- Street Address
- 6713 South Eastern Ave
- City
- Las Vegas
- State
- NV
- ZipCode
- 89119
Whole Hemp Plant Extract Full Spectrum by HempWorx: Common Questions
Does Whole Hemp Plant Extract Full Spectrum by HempWorx interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is hemp extract safe to take while pregnant or breastfeeding?
Can I be allergic to hemp extract?
Does this product actually work for anything?
Why is a concentrated extract riskier than hemp seed food?
What should I do if I'm on birth control or hormone therapy?
Is this hemp extract the same as CBD or THC?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Whole Hemp Plant Extract Full Spectrum is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Whole Hemp Plant Extract Full Spectrum’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Whole Hemp Plant Extract Full Spectrum's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hemp 12 references
- Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
- Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
- Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
- Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
- Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
- Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
- Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
- Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
- Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
- Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
- Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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