Lorazepam

31 interactions 2 explained in plain English
Also sold as: Ativan Loreev
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Orlistat Aripiprazole Injection Levodopa Oral Inhalation Nalbuphine Injection Hydroxychloroquine
24 Major 7 Moderate
All (31) Major (24) Moderate (7)

Major

Lorazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Lorazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Lorazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Lorazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Lorazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Lorazepam Calcifediol Rayaldee Altered serum levels of calcifediol Details Lorazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Lorazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Lorazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Lorazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Lorazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Lorazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Lorazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Lorazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Lorazepam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Lorazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Lorazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Lorazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Lorazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Lorazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Lorazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Lorazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Lorazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Lorazepam Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Lorazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Lorazepam Estradiol Delestrogen Decreased lorazepam effectiveness Details Lorazepam Estradiol Topical Divigel Decreased lorazepam effectiveness Details Lorazepam Estradiol Transdermal Patch Alora® Decreased lorazepam effectiveness Details Lorazepam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Lorazepam Levonorgestrel After banger Decreased lorazepam effectiveness Details Lorazepam Levonorgestrel Intrauterine System Kyleena Decreased lorazepam effectiveness Details

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