Oxazepam

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Buprenorphine Midazolam Nasal Spray Nalbuphine Injection Diazepam Nasal Spray Midazolam Injection
21 Major 1 Moderate
All (22) Major (21) Moderate (1)

Major

Oxazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Oxazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Oxazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Oxazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Oxazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Oxazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Oxazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Oxazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Oxazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Oxazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Oxazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Oxazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Oxazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Oxazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Oxazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Oxazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Oxazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Oxazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Oxazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Oxazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Oxazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Oxazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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