Phenoxybenzamine

16 interactions 1 explained in plain English
Also sold as: Dibenzyline Dibenzyline®
About Phenoxybenzamine

Phenoxybenzamine is used to treat episodes of high blood pressure and sweating related to pheochromocytoma. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Phenoxybenzamine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Alfuzosin Melphalan Melphalan Injection
3 Major 13 Moderate
All (16) Major (3) Moderate (13)

Major

Phenoxybenzamine Alfuzosin UroXatral Increased effects of alpha adrenergic blockade Details Phenoxybenzamine Melphalan Alkeran An increased risk of severe hypotension Details Phenoxybenzamine Melphalan Injection Alkeran An increased risk of severe hypotension Details

Moderate

Phenoxybenzamine Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Phenoxybenzamine Atenolol Tenormin Explained An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Acebutolol Sectral® An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Avanafil Stendra Increased risk of hypotension Details Phenoxybenzamine Betaxolol Betoptic S An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Betaxolol Ophthalmic Betoptic® An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Bisoprolol Zebeta® An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Esmolol Brevibloc An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Labetalol Normodyne® An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Levobunolol Ophthalmic AKBeta® An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Nadolol Corgard An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Nebivolol Bystolic An exaggerated hypotensive response to the first dose of the alpha blocker Details Phenoxybenzamine Penbutolol Levatol® An exaggerated hypotensive response to the first dose of the alpha blocker Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.