Rasagiline

50 interactions 6 explained in plain English

Also sold as: Azilect

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Morphine Injection Maprotiline Methylphenidate Methyldopa Deutetrabenazine

10 Contraindicated 31 Major 9 Moderate

All (50) Contraindicated (10) Major (31) Moderate (9)

Major

Rasagiline Amitriptyline Elavil Explained Severe CNS toxicity Details Rasagiline Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Rasagiline Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity Details Rasagiline Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Rasagiline Besifloxacin Ophthalmic Besivance Increased rasagiline exposure Details Rasagiline Butorphanol Injection Butorphic Increased risk of serotonin syndrome or opioid toxicity Details Rasagiline Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome or opioid toxicity Details Rasagiline Dolasetron Anzemet Increased risk of serotonin syndrome Details Rasagiline Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Rasagiline Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects and an increased risk of serotonin syndrome Details Rasagiline Gatifloxacin Ophthalmic Zymar® Increased rasagiline exposure Details Rasagiline Gemifloxacin Factive Increased rasagiline exposure Details Rasagiline Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Rasagiline Granisetron Injection Granisol Increased risk of serotonin syndrome Details Rasagiline Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome or opioid toxicity Details Rasagiline Hydromorphone Rectal available generically Increased risk of serotonin syndrome or opioid toxicity Details Rasagiline Levodopa Oral Inhalation Inbrija Increased risk of levodopa adverse effects, including severe orthostatic hypotension Details Rasagiline Levofloxacin Levaquin Increased rasagiline exposure Details Rasagiline Levofloxacin Injection Levaquin Increased rasagiline exposure Details Rasagiline Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Rasagiline Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Rasagiline Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details Rasagiline Moxifloxacin Avelox Increased rasagiline exposure Details Rasagiline Moxifloxacin Injection Avelox Increased rasagiline exposure Details Rasagiline Moxifloxacin Ophthalmic Moxeza® Increased rasagiline exposure Details Rasagiline Nalbuphine Injection Nubain® Increased risk of serotonin syndrome or opioid toxicity Details Rasagiline Ofloxacin Floxin® Increased rasagiline exposure Details Rasagiline Ofloxacin Ophthalmic Ocuflox Increased rasagiline exposure Details Rasagiline Ofloxacin Otic Floxin® Otic Increased rasagiline exposure Details Rasagiline Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Rasagiline Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.