Thiotepa

Name: Thiotepa Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 1 explained in plain English

Also sold as: Tepadina Tepylute

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Ketoconazole Topical Letermovir Injection

3 Major 5 Moderate

All (8) Major (3) Moderate (5)

Major

Thiotepa Abametapir Explained Increased exposure of CYP3A4 substrate Details Thiotepa Ketoconazole Topical Extina® Foam Increased thiotepa exposure and an increased risk of thiotepa-related adverse effects and toxicity Details Thiotepa Letermovir Injection Prevymis Increased CYP3A substrate exposure Details

Moderate

Thiotepa Cyclophosphamide Cytoxan® Reduced cyclophosphamide conversion to the active metabolite 4-hydroxycyclophosphamide and reduced efficacy of cyclophosphamide Details Thiotepa Cyclophosphamide Injection Cytoxan® Injection Reduced cyclophosphamide conversion to the active metabolite 4-hydroxycyclophosphamide and reduced efficacy of cyclophosphamide Details Thiotepa Esketamine Nasal Spray Spravato Increased CYP2B6 substrates exposure Details Thiotepa Ifosfamide Injection Ifex Increased CYP2B6 substrates exposure Details Thiotepa Nevirapine Viramune Increased CYP2B6 substrates exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.