Drug & supplement interaction

1,3-dmaa + Emapalumab-Lzsg

Emapalumab-Lzsg brand name: Gamifant.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 1,3-dmaa and Emapalumab-Lzsg in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

1,3-dmaa and Emapalumab-Lzsg

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Emapalumab-Lzsg and 1,3-dmaa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1,3-dmaa safety at a glance

1,3-dmaa overall Avoid DMAA is banned in supplements in many countries and tied to serious cardiovascular harm.
Pregnancy Avoid It is an unsafe stimulant with no safety data; do not use during pregnancy.
Breastfeeding Avoid No safety data and known stimulant risks; do not use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Emapalumab-Lzsg and 1,3-dmaa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Emapalumab-Lzsg

Interactions in our licensed database are recorded against drug classes, not just single drug names. Emapalumab-Lzsg is filed under a single classification — immunosuppressants. 1,3-dmaa has documented interactions with 2 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate) and stimulant drugs (moderate) — and none of Emapalumab-Lzsg’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1,3-dmaa Does Interact With Other Medications

1,3-dmaa has 321 moderate known drug interactions in our database — Emapalumab-Lzsg isn’t one of them. If you take anything else, check it against the full list below.

Moderate 321 No known interaction 2,509 (incl. Emapalumab-Lzsg)
Taking anything else?

Check Another of Your Medications Against 1,3-dmaa

Covers the 2,830 medications we’ve checked against 1,3-dmaa. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests 1,3-dmaa and Emapalumab-Lzsg May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    1,3-dmaa

    “Orally, taking 1,3-DMAA combination products (OxyELITE Pro, AmphetaLean, or Jack3d, USPlabs) has been reported to cause cardiac arrest, atrial fibrillation, chest pressure, angina, tachycardia, palpitations, hypertension, hypotension, myocardial infarction, and acute coronary syndrome. Increased heart rate and blood pressure have also been reported.”

    1,3-dmaa · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 17660. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
    2. 91680. Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2. PubMed
    3. 94361. Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. PubMed
    4. 94362. Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4. PubMed
    5. 94365. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
    6. 94369. Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med. 2012 Dec;177(12):1455-9. PubMed

    “Due to the stimulant effects of 1,3-DMAA, there is concern that it might increase the risk of adverse cardiovascular events similar to synephrine from bitter orange or ephedrine from ephedra. Cardiovascular outcomes have rarely been assessed in patients taking 1,3-DMAA alone. Most adverse effects are linked to 1,3-DMAA-containing combination products.”

    1,3-dmaa · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 17660. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
    2. 91680. Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2. PubMed
    3. 94365. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
    4. 94371. Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed
    5. 94362. Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4. PubMed
    6. 94377. Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81. PubMed

    Emapalumab-Lzsg

    Listed in the ADVERSE REACTIONS section of the FDA label for Emapalumab-Lzsg. Read the label on DailyMed ›

  • Mood changes or irritability Additional detail

    1,3-dmaa

    “Orally, taking 1,3-DMAA-containing combination products has been reported to cause feelings of anxiety, suicidal behavior, agitation or irritability, paranoia, depression, panic, and aggression or combativeness.”

    1,3-dmaa · Natural Medicines adverse-effect record, reported in anxiety.

    5 sources cited
    1. 17907. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
    2. 94365. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
    3. 94371. Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed
    4. 94377. Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81. PubMed
    5. 17660. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.

    Emapalumab-Lzsg

    Listed in the ADVERSE REACTIONS section of the FDA label for Emapalumab-Lzsg. Read the label on DailyMed ›

  • Sweating / Tiredness / Headache Additional detail

    1,3-dmaa

    “Orally, taking specific 1,3-DMAA-containing combination products (OxyELITE Pro or Jack3d, USPlabs) has been reported to cause feelings of jitters, sleeplessness, shakiness, chills, sweating, fatigue, tingling, and lack of focus in clinical trials.”

    1,3-dmaa · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 17907. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
    2. 17660. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
    3. 17908. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
    4. 94365. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
    5. 94368. Dunn M. Have prohibition policies made the wrong decision? A critical review of studies investigating the effects of DMAA. Int J Drug Policy. 2017 Feb;40:26-34. PubMed
    6. 94371. Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed

    Emapalumab-Lzsg

    Listed in the ADVERSE REACTIONS section of the FDA label for Emapalumab-Lzsg. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    1,3-dmaa

    Recorded for 1,3-dmaa in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

    Emapalumab-Lzsg

    Listed in the ADVERSE REACTIONS section of the FDA label for Emapalumab-Lzsg. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting Additional detail

    1,3-dmaa

    “Orally, taking 1,3-DMAA-containing combination products has been reported to cause nausea, vomiting, diarrhea, vomiting blood, and abdominal pain.”

    1,3-dmaa · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 17907. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
    2. 17908. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
    3. 94365. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
    4. 94371. Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed
    5. 94377. Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81. PubMed
    6. 17663. Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.

    Emapalumab-Lzsg

    Listed in the ADVERSE REACTIONS section of the FDA label for Emapalumab-Lzsg. Read the label on DailyMed ›

Reported for 1,3-dmaa but not commonly for Emapalumab-Lzsg: a heart attack, an irregular heartbeat, blurred vision and a stroke or mini-stroke.

Effects for Emapalumab-Lzsg come from the ADVERSE REACTIONS section of its FDA label; effects for 1,3-dmaa come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Emapalumab-Lzsg

This page covers 1,3-dmaa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Emapalumab-Lzsg page lists 53 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate), Andrographis (moderate) and Ashwagandha (moderate).

By severity: 52 moderate · 1 minor.

From our pharmacist’s overview on the Emapalumab-Lzsg page

“Emapalumab-lzsg (Gamifant) quiets an immune system that has turned dangerously overactive in a rare condition called hemophagocytic lymphohistiocytosis. All 53 supplement interactions on file share a single theme, a possible boost to immune activity that could work against the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Emapalumab-Lzsg interaction page

One more smart check

Taking 1,3-dmaa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 94 real supplement products containing 1,3-dmaa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1,3-dmaa. Even though 1,3-dmaa itself has no known interaction with Emapalumab-Lzsg, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 1,3-dmaa and Emapalumab-Lzsg Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1,3-dmaa
Top half

#424 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Emapalumab-Lzsg
Steady interest

#2,125 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,3-dmaa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1,3-dmaa and Emapalumab-Lzsg records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1,3-dmaa

What is 1,3-dmaa?

1,3-dmaa
  • Energy and stimulation
  • Pre-workout performance
  • Weight loss
  • Appetite suppression
  • Focus and concentration

DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, including high blood pressure, heart problems, strokes, and deaths. The U.S. FDA and regulators in many countries have declared it illegal and unsafe in dietary supplements, so it should be avoided.

Synthetic compound (not a true plant part); sometimes claimed to come from geranium · Capsules, tablets, pre-workout powders (often as a hidden ingredient)

An interaction check asks whether these two react with each other — it does not ask whether 1,3-dmaa is a good idea for someone in your situation. Here is what our 1,3-dmaa record says about it on its own.

1,3-dmaa: dosing

There is no safe or established dose of DMAA. It is not approved as a dietary supplement ingredient, and we do not recommend taking it in any amount.Because DMAA may be hidden in some products, the safest approach is to avoid pre-workout or weight-loss supplements that list ingredients like dimethylamylamine, methylhexanamine, or Geranamine.

From our 1,3-dmaa monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1,3-dmaa monograph & all interactions
Medication

About Emapalumab-lzsg Injection

What Is Emapalumab-lzsg Injection Used For?

Brand name: Gamifant

Gamifant is used to treat primary hemophagocytic lymphohistiocytosis (HLH) — a rare, life-threatening condition where the immune system becomes dangerously overactivated — in adults and children whose disease has not responded to, has come back during, or has progressed on standard HLH therapy, or who cannot tolerate it.

Gamifant is also used for HLH/macrophage activation syndrome (MAS) in adults and children with known or suspected Still's disease, including systemic Juvenile Idiopathic Arthritis (sJIA), when glucocorticoids (steroid medicines) have not worked well enough, cannot be tolerated, or when MAS keeps coming back.

See full Emapalumab-lzsg Injection drug information
Keep checking

Other Drugs & 1,3-dmaa

Browse every other medication we’ve checked against 1,3-dmaa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
321Moderate
0Minor
2,508No known interaction
321 Moderate 2,508 No interaction
Moderate

321 interactions

Showing 60 of 321 moderate interactions — see all 321 on the 1,3-dmaa page.

No interaction 2,508 drugs checked — show the list

We also checked 1,3-dmaa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,508 medications checked with no known interaction — see the full 1,3-dmaa list.

See the full 1,3-dmaa interactions page
See every supplement checked against Emapalumab-Lzsg, ranked by severity
Evidence & sources

1,3-dmaa References

The 21 references that drive our 1,3-dmaa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
  2. Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
  3. Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).
  4. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
  5. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
  6. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
  7. Young C, Oladipo O, Frasier S, et al. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Mil Med 2012;177(12):1450-4. PubMed
  8. Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2. PubMed
  9. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  10. Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. PubMed
  11. Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4. PubMed
  12. Bloomer RJ, Farney TM, Harvey IC, Alleman RJ. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Hum Exp Toxicol. 2013 Nov;32(11):1126-36. PubMed
  13. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
  14. Dolan SB, Gatch MB. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015 Jan 1;146:97-102. PubMed
  15. Dunn M. Have prohibition policies made the wrong decision? A critical review of studies investigating the effects of DMAA. Int J Drug Policy. 2017 Feb;40:26-34. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1,3-dmaa and Emapalumab-Lzsg Together: Common Questions

Is it safe to take 1,3-dmaa with Emapalumab-Lzsg?
We do not list a known interaction between 1,3-dmaa and Emapalumab-Lzsg. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do 1,3-dmaa and Emapalumab-Lzsg have any of the same side effects?
Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the 1,3-dmaa and Emapalumab-Lzsg combination checked?
Interactions in our licensed database are recorded against drug classes. Emapalumab-Lzsg is filed under 1 classification, and 1,3-dmaa has documented interactions with 2 drug classes — none of Emapalumab-Lzsg's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1,3-dmaa interact with any other medications?
Yes. 1,3-dmaa has 321 documented drug interactions in our database — Emapalumab-Lzsg is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Emapalumab-Lzsg interact with any supplements?
Yes. Emapalumab-Lzsg has documented interactions with 53 supplements in our database — 1,3-dmaa is not one of them. The Emapalumab-Lzsg interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1,3-dmaa monograph Uses, safety profile, and every drug interaction in one place Emapalumab-lzsg Injection drug information The full plain-English guide to this medication Emapalumab-Lzsg supplement interactions Every supplement checked against Emapalumab-Lzsg, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Emapalumab-Lzsg and 1,3-dmaa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.