1,3-dmaa + Losartan Potassium
Losartan Potassium brand name: Cozaar.
We found no known interaction between 1,3-dmaa and Losartan Potassium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
1,3-dmaa and Losartan Potassium
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Losartan Potassium and 1,3-dmaa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
1,3-dmaa safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Losartan Potassium
Interactions in our licensed database are recorded against drug classes, not just single drug names. Losartan Potassium is filed under 7 classifications — including angiotensin receptor blockers (arbs), cytochrome p450 2c9 (cyp2c9) substrates, antihypertensive drugs. 1,3-dmaa has documented interactions with 2 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate) and stimulant drugs (moderate) — and none of Losartan Potassium’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
1,3-dmaa Does Interact With Other Medications
1,3-dmaa has 321 moderate known drug interactions in our database — Losartan Potassium isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 1,3-dmaa
We haven’t checked that one against 1,3-dmaa yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 1,3-dmaa. Pick one to open its full report.
Questions About 1,3-dmaa or Losartan Potassium
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 1,3-dmaa or Losartan Potassium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can I Drink Essiac Tea With My Blood Pressure and Thyroid Meds? ›
- Is Rhodiola Safe To Take With Thyroid Medications? ›
- Saw Palmetto With Junel Interaction ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Losartan Potassium
This page covers 1,3-dmaa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Losartan Potassium page lists 253 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and St. John's Wort (major).
By severity: 6 major · 205 moderate · 42 minor.
From our pharmacist’s overview on the Losartan Potassium page
“Losartan potassium (Cozaar) treats high blood pressure, and this is a list to respect, because six of its 253 supplement interactions carry a major rating. Most entries do one of two things.”
Reviewed by 2 · Jul 18, 2026
Taking 1,3-dmaa as Part of a Dietary Supplement Product? Check It for Interactions
We hold 94 real supplement products containing 1,3-dmaa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1,3-dmaa. Even though 1,3-dmaa itself has no known interaction with Losartan Potassium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where 1,3-dmaa and Losartan Potassium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#413 of 1,452 supplements looked up here in the last 7 days
#6 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,3-dmaa reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1,3-dmaa and Losartan Potassium records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 1,3-dmaa
What is 1,3-dmaa?
- Energy and stimulation
- Pre-workout performance
- Weight loss
- Appetite suppression
- Focus and concentration
DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, including high blood pressure, heart problems, strokes, and deaths. The U.S. FDA and regulators in many countries have declared it illegal and unsafe in dietary supplements, so it should be avoided.
Synthetic compound (not a true plant part); sometimes claimed to come from geranium · Capsules, tablets, pre-workout powders (often as a hidden ingredient)
An interaction check asks whether these two react with each other — it does not ask whether 1,3-dmaa is a good idea for someone in your situation. Here is what our 1,3-dmaa record says about it on its own.
1,3-dmaa: dosing
There is no safe or established dose of DMAA. It is not approved as a dietary supplement ingredient, and we do not recommend taking it in any amount.Because DMAA may be hidden in some products, the safest approach is to avoid pre-workout or weight-loss supplements that list ingredients like dimethylamylamine, methylhexanamine, or Geranamine.
From our 1,3-dmaa monograph — the full record covers uses, side effects and every documented interaction.
About Losartan
What Is Losartan Used For?
Brand name: Cozaar
Losartan tablets — available as branded Cozaar and several generic products — are used to treat high blood pressure (hypertension) in adults and children 6 years and older. Lowering blood pressure reduces the risk of strokes and heart attacks. Losartan tablets are also used to reduce the risk of stroke in people with high blood pressure who also have left ventricular hypertrophy (an enlarged left side of the heart). Note: evidence suggests this stroke-risk benefit may not apply to Black patients.
Losartan tablets are additionally approved to protect the kidneys in people with type 2 diabetes, high blood pressure, and signs of kidney damage (diabetic nephropathy). Arbli, the oral suspension form, shares these same approved uses.
Most-Reported Side Effects for Losartan Potassium
From FAERS, the FDA’s public side-effect reporting system (89,498 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & 1,3-dmaa
Browse every other medication we’ve checked against 1,3-dmaa — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
321 interactions
- Phentermine ›
- Methylphenidate ›
- Propranolol ›
- Lidocaine ›
- Phenylpropanolamine ›
- Fentanyl ›
- Nicotine ›
- Oxycodone ›
- Dextromethorphan ›
- Formoterol ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Diethylpropion ›
- Lofepramine ›
- Nortriptyline ›
- Propoxyphene ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Fluphenazine ›
- Modafinil ›
- Oxymetazoline Hydrochloride ›
- Paroxetine ›
- Timolol ›
- Tramadol ›
- Vortioxetine ›
- Amphetamine Sulfate ›
- Aripiprazole Lauroxil ›
- Caffeine (prescription Drug) ›
- Carvedilol ›
- Chlorpromazine ›
- Chlorpropamide ›
- Clomipramine ›
- Clozapine ›
- Cocaine Hydrochloride (prescription Drug) ›
- Desvenlafaxine ›
- Ephedrine Sulfate ›
- Fluoxetine ›
- Galantamine ›
- Hydrocodone ›
- Hydrocodone Bitartrate ›
- Imipramine ›
- Meperidine ›
- Methylphenidate Hydrochloride ›
- Metoprolol ›
- Nebivolol ›
- Oxycodone Hydrochloride ›
- Pemoline ›
- Pindolol ›
- Propafenone ›
- Pseudoephedrine Sulfate ›
- Quetiapine ›
- Risperidone ›
- Tamoxifen Citrate ›
- Tolterodine ›
Showing 60 of 321 moderate interactions — see all 321 on the 1,3-dmaa page.
No interaction 2,508 drugs checked — show the list
We also checked 1,3-dmaa against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Atorvastatin Calcium ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Finasteride ›
Showing the 60 most looked-up of 2,508 medications checked with no known interaction — see the full 1,3-dmaa list.
1,3-dmaa References
The 21 references that drive our 1,3-dmaa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
- Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
- Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).
- McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
- McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
- Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
- Young C, Oladipo O, Frasier S, et al. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Mil Med 2012;177(12):1450-4. PubMed
- Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2. PubMed
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
- Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. PubMed
- Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4. PubMed
- Bloomer RJ, Farney TM, Harvey IC, Alleman RJ. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Hum Exp Toxicol. 2013 Nov;32(11):1126-36. PubMed
- Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
- Dolan SB, Gatch MB. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015 Jan 1;146:97-102. PubMed
- Dunn M. Have prohibition policies made the wrong decision? A critical review of studies investigating the effects of DMAA. Int J Drug Policy. 2017 Feb;40:26-34. PubMed
- Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med. 2012 Dec;177(12):1455-9. PubMed
- Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed
- Palmer PG Jr. Deadly dimethylamylamine: "health" supplements are killing consumers while current regulations impede FDA action. J Leg Med. 2014;35(2):311-36. PubMed
- Schilling BK, Hammond KG, Bloomer RJ, Presley CS, Yates CR. Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men. BMC Pharmacol Toxicol. 2013 Oct 4;14:52. PubMed
- Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81. PubMed
- Whitehead PN, Schilling BK, Farney TM, Bloomer RJ. Impact of a dietary supplement containing 1,3-dimethylamylamine on blood pressure and bloodborne markers of health: a 10-week intervention study. Nutr Metab Insights. 2012 Feb 2;5:33-9. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Losartan Potassium Is Linked to Lower Levels of One Nutrient
Natural Medicines records Losartan Potassium as a medicine that can lower these. This is not an interaction with 1,3-dmaa — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Losartan Potassium nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking 1,3-dmaa and Losartan Potassium Together: Common Questions
Is it safe to take 1,3-dmaa with Losartan Potassium?
Do 1,3-dmaa and Losartan Potassium have any of the same side effects?
How was the 1,3-dmaa and Losartan Potassium combination checked?
Does 1,3-dmaa interact with any other medications?
Does Losartan Potassium interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Losartan Potassium and 1,3-dmaa?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.