Apple Cider Vinegar - Botox (Botulinum Toxin Type A) Interaction
Herbal: Apple Cider Vinegar
Also Known As: ACV, Cider Vinegar, Vinagre de Manzana, Vinagre de Sidra de Manzana, Vinaigre de Cidre
Drug: Botulinum Toxin Type A
Brand names:
Botox

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
There were no interactions found between Botulinum Toxin Type A and Apple Cider Vinegar. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
The use of apple cider vinegar or the amounts of ACV in supplements is unlikely to cause clinically significant drug interactions at recommended dosages.
However, it is important to be aware of potential interactions, especially with medications that lower blood glucose levels, as these interactions have been theoretically proposed, but as I've written in my analysis on individual interaction detail pages, even this interaction is unlikely to be clinically significant for most.
In terms of side effects, it is uncommon for individuals to experience any adverse effects from taking ACV, but some mild side effects, such as nausea and indigestion, have been reported. It is important to consider that these side effects could be additive if taken with other medications that cause similar symptoms.
As always, it is important to consult with a healthcare provider before starting any new supplement, including ACV, to ensure its safe and appropriate use for your specific medical situation.
Apple Cider Vinegar Overview

Botulinum Toxin Type A Overview
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OnabotulinumtoxinA injection (Botox, Botox Cosmetic) is used to treat a number of conditions.
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OnabotulinumtoxinA injection (Botox) is used to:
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relieve the symptoms of cervical dystonia (spasmodic torticollis; uncontrollable tightening of the neck muscles that may cause neck pain and abnormal head positions) in people 16 years of age and older;
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relieve the symptoms of strabismus (an eye muscle problem that causes the eye to turn inward or outward) and blepharospasm (uncontrollable tightening of the eyelid muscles that may cause blinking, squinting, and abnormal eyelid movements) in adults and adolescents 12 years of age and older;
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prevent headaches in people older than 18 years of age with chronic migraine (severe, throbbing headaches that are sometimes accompanied by nausea and sensitivity to sound or light) who have 15 or more days each month with headaches lasting 4 hours a day or longer;
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treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in people 18 years of age and older when other medications do not work well enough or cannot be taken;
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treat neurogenic detrusor overactivity (NDO; a bladder control condition caused by brain, spinal cord or nerve problem) in children 5 years of age and older when other medications did not help or could not be tolerated;
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treat incontinence (leakage of urine) in people 18 years of age and older with overactive bladder (condition in which the bladder muscles have uncontrollable spasms) caused by nerve problems such as spinal cord injury or multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control), who cannot be treated with oral medication;
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treat spasticity (muscle stiffness and tightness) of muscles in the arms and legs in adults and children 2 years of age and older;
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treat severe underarm sweating in people 18 years of age and older who cannot be treated with products applied on the skin;
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and
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OnabotulinumtoxinA injection (Botox Cosmetic) is used to
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temporarily smooth frown lines (wrinkles between the eyebrows) in adults 18 years of age and older,
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temporarily smooth crow's feet lines (wrinkles near the outer corner of the eye) in adults 18 years of age and older,
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and to temporarily smooth forehead lines in adults 18 years of age and older.
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OnabotulinumtoxinA injection is in a class of medications called neurotoxins. When onabotulinumtoxinA is injected into a muscle, it blocks the nerve signals that cause uncontrollable tightening and movements of the muscle. When onabotulinumtoxinA is injected into a sweat gland, it decreases the activity of the gland to reduce sweating. When onabotulinumtoxinA is injected into the bladder, it decreases bladder contractions and blocks signals that tell the nervous system that the bladder is full.
Apple Cider Vinegar - More Interactions
Apple Cider Vinegar interacts with 160 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.