Cannabidiol (cbd) + Aspirin, Carisoprodol, Codeine Phosphate
Aspirin, Carisoprodol, Codeine Phosphate brand name: Soma Compound w/ Codeine.
Aspirin, Carisoprodol, Codeine Phosphate falls into 3 drug categories that Cannabidiol (cbd) can interact with; the most serious is rated moderate. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.
Read the full interaction reportCannabidiol (cbd) and Aspirin, Carisoprodol, Codeine Phosphate
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Cannabidiol (cbd) interacts with whole categories of medication. Aspirin, Carisoprodol, Codeine Phosphate falls into 3 of those categories, so it can interact with Cannabidiol (cbd) in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 3Why this applies to Aspirin, Carisoprodol, Codeine Phosphate
Aspirin, Carisoprodol, Codeine Phosphate falls under CNS DEPRESSANTS — the group Cannabidiol (cbd) interacts with.
Preliminary clinical research, case reports, and animal studies suggest that high dose cannabidiol has sedative and hypnotic effects. Theoretically, concomitant use of cannabidiol with drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination pill packs two ingredients that already make you drowsy: carisoprodol (a muscle relaxer) and codeine (an opioid pain reliever). CBD can add to that sleepiness. Higher doses of CBD seem to have their own calming, sedative effect, so stacking it on top of these medicines could leave you feeling extra groggy, dizzy, or slow to react.
The bigger picture: more sedation can mean slower breathing, trouble staying alert, and a higher fall risk, especially in older adults. Keep in mind this is a theoretical concern based on how these drugs work, not proven head-to-head studies, so don't panic. Just be honest with your pharmacist or doctor about any CBD you use, and avoid driving until you know how the mix affects you.
- Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol 1981;21(8-9 Suppl):417S-27S. PubMed
- Monti JM. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology (Berl) 1977;55(3):263-5. PubMed
- Pickens JT. Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content. Br J Pharmacol 1981;72(4):649-56.
- Perez-Vilar S, Karami S, Long K, Leishear K. Cannabidiol exposures in the United States, National Poison Data System, July 2014-June 2021. Clin Toxicol (Phila) 2022. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 3Aspirin, Carisoprodol, Codeine Phosphate also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research shows that cannabidiol inhibits CYP2D6. Theoretically, concomitant use of cannabidiol with CYP2D6 substrates might increase the risk for adverse effects from these substrates. However, a clinical crossover trial in healthy adults shows that cannabidiol does not inhibit dextromethorphan, a substrate of CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination pill contains codeine, which is the part that matters most here. Codeine is actually a prodrug, meaning your body has to convert it (using an enzyme called CYP2D6) into morphine before you feel real pain relief. In lab studies, CBD can slow down that same CYP2D6 enzyme.
So in theory, CBD could leave less codeine getting turned into active morphine, meaning you might get weaker pain relief than expected. The good news is this is only a theoretical concern based on test-tube data, and a human study with a similar CYP2D6 drug showed no real effect. I wouldn't lose sleep over it, but if your pain isn't well controlled, mention the CBD to your pharmacist or doctor before changing anything.
- Yamaori S, Okamoto Y, Yamamoto I, Watanabe K. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos 2011;39(11):2049-56. PubMed
- Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
- Bansal S, Zamarripa CA, Spindle TR, et al. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clin Pharmacol Ther 2023.
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
3 of 3Aspirin, Carisoprodol, Codeine Phosphate also falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES.
Research shows that cannabidiol inhibits CYP2C19. In clinical studies and case reports, cannabidiol use resulted in significant increases in the serum levels of topiramate, methadone, citalopram, omeprazole, and N-desmethylclobazam, the primary active metabolite of clobazam. These chemicals are metabolized by CYP2C19. Concomitant use of cannabidiol with CYP2C19 substrates may increase the risk for adverse effects from these substrates.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
This combination pill packs three ingredients, and the one that matters most here is carisoprodol (Soma). Your body uses an enzyme called CYP2C19 to turn carisoprodol into meprobamate, a sedating compound. CBD can slow that same enzyme down, which may let carisoprodol and its byproducts hang around longer than usual.
In plain terms, you could feel more drowsy, dizzy, or foggy than expected, especially since codeine is also a sedating, breath-slowing opioid. That added sleepiness is the real concern when you stack these together. The evidence that CBD blocks CYP2C19 is solid, so don't brush it off. Please check with your pharmacist or doctor before pairing CBD with this medicine, rather than adjusting anything on your own.
- Harvey DJ. Absorption, distribution, and biotransformation of the cannabinoids. Marijuana and Medicine. 1999;91-103. DOI
- Bornheim LM, Everhart ET, Li J, Correia MA. Characterization of cannabidiol-mediated cytochrome P450 inactivation. Biochem Pharmacol 1993;45(6):1323-31. PubMed
- Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP; UAB CBD Program. Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017 Sep;58(9):1586-92. PubMed
- Devinsky O, Marsh E, Friedman D, et la. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 2016 Mar;15(3):270-8.
- Geffrey AL, Pollack SF, Bruno PL, Thiele EA. Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy. Epilepsia. 2015 Aug;56(8):1246-51. PubMed
- Madden K, Tanco K, Bruera E. Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol. Pediatrics. 2020;e20193256. PubMed
- Anderson LL, Doohan PT, Oldfield L, et al. Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People. J Clin Psychopharmacol. 2021. PubMed
- Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
- Bansal S, Zamarripa CA, Spindle TR, et al. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clin Pharmacol Ther 2023.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Cannabidiol (cbd) Also Interacts With Other Medications
Cannabidiol (cbd) has 1,050 moderate known drug interactions in our database — the Aspirin, Carisoprodol, Codeine Phosphate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cannabidiol (cbd)
We haven’t checked that one against Cannabidiol (cbd) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cannabidiol (cbd). Pick one to open its full report.
See Every Supplement That Interacts With Aspirin, Carisoprodol, Codeine Phosphate
This page covers Cannabidiol (cbd) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Carisoprodol, Codeine Phosphate page lists 339 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 11 major · 292 moderate · 36 minor.
From our pharmacist’s overview on the Aspirin, Carisoprodol, Codeine Phosphate page
“Soma Compound with Codeine packs aspirin, carisoprodol, and codeine into one tablet, and I read its list of 339 interacting supplement ingredients as a genuine warning, not fine print. Most, 202 of them, can add to aspirin's blood-thinning effect and raise bleeding risk.”
Reviewed by 2 · Jul 18, 2026
Open the Aspirin, Carisoprodol, Codeine Phosphate interaction page
Where Cannabidiol (cbd) and Aspirin, Carisoprodol, Codeine Phosphate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#484 of 1,452 supplements looked up here in the last 7 days
#667 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Cannabidiol (cbd)
What is Cannabidiol (cbd)?
- Anxiety and stress
- Sleep problems
- Chronic pain
- Certain seizure disorders
- Inflammation
CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorders (as a prescription drug), while most other popular uses are still backed by limited or early research. Product quality varies a lot, so talk with your pharmacist or doctor before using it, especially if you take other medicines.
Other Drugs & Cannabidiol (cbd)
Browse every other medication we’ve checked against Cannabidiol (cbd) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,050 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Diphenhydramine ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Orphenadrine ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Griseofulvin ›
- Ivabradine ›
Showing 60 of 1,050 moderate interactions — see all 1,050 on the Cannabidiol (cbd) page.
No interaction 1,779 drugs checked — show the list
We also checked Cannabidiol (cbd) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Aspirin ›
- Rosuvastatin ›
- Docusate ›
- Tirzepatide ›
- Hydroxyurea ›
- Valacyclovir ›
- Semaglutide ›
- Sumatriptan ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Azithromycin ›
- Methylene Blue ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Cyclopentolate ›
- Cephalexin ›
- Amoxicillin, Clavulanate Potassium ›
- Mannitol ›
- Ezetimibe ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Pegunigalsidase Alfa-iwxj ›
- Spironolactone ›
- Thyroid Hormone ›
- Daptomycin ›
- Carbidopa, Levodopa ›
- Mitomycin ›
- Acetylsalicylic Acid ›
- Hexobarbitone ›
- Levodopa ›
- Factor 7a ›
- Cefaclor ›
- Minoxidil ›
- Bentoquatam ›
- Hethylphenidate Hcl ›
- Azelaic Acid ›
- Lenvatinib ›
- Pizotifen ›
- Phenylephrine ›
- Hydroxychloroquine ›
- Rocuronium ›
- Salbutamol Sulfate ›
- Insulin Degludec, Liraglutide ›
- Ribavirin Aerosol ›
- Alglucosidase Alpha ›
- Flutemetamol F-18 ›
- Procainamide ›
- Insulin Human, Sodium Chloride ›
- Vancomycin ›
- Canagliflozin, Metformin ›
- Hydrochlorothiazide, Lisinopril ›
- Triptorelin ›
- Magnesium Hydroxide (otc Drug) ›
Showing the 60 most looked-up of 1,779 medications checked with no known interaction — see the full Cannabidiol (cbd) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Carisoprodol, Codeine Phosphate Is Linked to Lower Levels of 3 Nutrients
Natural Medicines records Aspirin, Carisoprodol, Codeine Phosphate as a medicine that can lower these. This is not an interaction with Cannabidiol (cbd) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Carisoprodol, Codeine Phosphate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cannabidiol (cbd) and Aspirin, Carisoprodol, Codeine Phosphate Together: Common Questions
Can you take Cannabidiol (cbd) with Aspirin, Carisoprodol, Codeine Phosphate?
Why are there 3 interactions listed for Cannabidiol (cbd) and Aspirin, Carisoprodol, Codeine Phosphate?
How serious is the Cannabidiol (cbd) and Aspirin, Carisoprodol, Codeine Phosphate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.