Drug & supplement interaction

Cannabigerol (cbg) + Aprocitentan

Aprocitentan brand name: Tryvio.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cannabigerol (cbg) has a moderate interaction with Aprocitentan. Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Cannabigerol (cbg) and Aprocitentan

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Aprocitentan

Aprocitentan falls under ANTIHYPERTENSIVE DRUGS — the group Cannabigerol (cbg) interacts with.

Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that an intraperitoneal injection of cannabigerol lowers blood pressure. The mechanism of action may be related to alpha-2-adrenoreceptor activity. The effect of oral intake of cannabigerol is unclear and this has not been shown in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: Aprocitentan (Tryvio) is a medicine that lowers blood pressure, usually added on when other pills aren't quite doing the job. CBG, at least in animal studies, seems to nudge blood pressure down too. So the concern is simple stacking. If both are pushing in the same direction, you could end up a little too low.

What might that feel like? Think lightheadedness, dizziness when you stand up, tiredness, or even a faint feeling. I want to be honest, though: this is theoretical, based on an injection in animals, not on people swallowing CBG. We really don't know how oral CBG behaves in humans. It's worth a quick chat with your pharmacist or doctor, especially if you already run on the low side or feel woozy.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Vernail VL, Bingaman SS, Silberman Y, Raup-Konsavage WM, Vrana KE, Arnold AC. Acute cannabigerol administration lowers blood pressure in mice. Front Physiol 2022;13:871962. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cannabigerol (cbg) Also Interacts With Other Medications

Cannabigerol (cbg) has 171 moderate known drug interactions in our database — the Aprocitentan one above is one of them. If you take anything else, check it against the full list below.

Moderate 171 No known interaction 2,659 (incl. Aprocitentan)
Taking anything else?

Check Another of Your Medications Against Cannabigerol (cbg)

Covers the 2,830 medications we’ve checked against Cannabigerol (cbg). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aprocitentan

This page covers Cannabigerol (cbg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aprocitentan page lists 189 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Siberian Cocklebur (major).

By severity: 7 major · 161 moderate · 21 minor.

From our pharmacist’s overview on the Aprocitentan page

“Aprocitentan (Tryvio) is prescribed when blood pressure stays high despite other medicines, so anything that pushes your pressure around cuts straight to why you take it. Most of the 189 ingredients here do exactly that: some add to the drop and can leave you dizzy or faint, while others, tyramine among them, push pressure back up and…”

Reviewed by 2 · Jul 18, 2026

Open the Aprocitentan interaction page

How much people look this up

Where Cannabigerol (cbg) and Aprocitentan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabigerol (cbg)
Steady interest

#1,081 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aprocitentan
Steady interest

#2,082 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cannabigerol (cbg)

What is Cannabigerol (cbg)?

  • Anxiety and stress
  • Pain and inflammation
  • Sleep support
  • Focus and mood
  • Digestive discomfort

Cannabigerol (CBG) is a minor cannabinoid from the cannabis (hemp) plant that is marketed for anxiety, pain, and inflammation, but human research is very limited and most claims rest on laboratory and animal studies. It appears to be generally well tolerated in early reports, but its long-term safety, quality, and dosing are not well established. Talk to your pharmacist or doctor before trying it, especially if you take other medicines or are pregnant or breastfeeding.

Read the full Cannabigerol (cbg) monograph & all interactions
Medication

About Aprocitentan

What Is Aprocitentan Used For?

Brand name: Tryvio

Tryvio (aprocitentan) is used to treat hypertension (high blood pressure) in adults. It is always used together with other blood pressure medicines — not as a stand-alone treatment — and is specifically for people whose blood pressure remains too high despite being on other drugs.

Lowering blood pressure reduces the risk of serious cardiovascular events such as strokes and heart attacks. Tryvio is not a first-choice blood pressure medicine; it is intended for patients with hard-to-control high blood pressure who need an additional option.

See full Aprocitentan drug information
Keep checking

Other Drugs & Cannabigerol (cbg)

Browse every other medication we’ve checked against Cannabigerol (cbg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
171Moderate
0Minor
2,658No known interaction
171 Moderate 2,658 No interaction
Moderate

171 interactions

Showing 60 of 171 moderate interactions — see all 171 on the Cannabigerol (cbg) page.

No interaction 2,658 drugs checked — show the list

We also checked Cannabigerol (cbg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,658 medications checked with no known interaction — see the full Cannabigerol (cbg) list.

See the full Cannabigerol (cbg) interactions page
See every supplement checked against Aprocitentan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cannabigerol (cbg) monograph › Uses, safety, and every drug interaction in one place Aprocitentan supplement interactions › Every supplement checked against Aprocitentan, ranked by severity Aprocitentan drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cannabigerol (cbg) and Aprocitentan Together: Common Questions

Can you take Cannabigerol (cbg) with Aprocitentan?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cannabigerol (cbg) and Aprocitentan interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aprocitentan and Cannabigerol (cbg)?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.