Drug & supplement interaction

Cannabigerol (cbg) + Naldemedine Tosylate

Naldemedine Tosylate brand name: Symproic.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Cannabigerol (cbg) and Naldemedine Tosylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cannabigerol (cbg) and Naldemedine Tosylate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naldemedine Tosylate and Cannabigerol (cbg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabigerol (cbg) safety at a glance

Cannabigerol (cbg) overall Use caution Early reports suggest it is usually well tolerated, but high-quality human safety data are lacking.
Pregnancy Avoid Cannabis-derived products are not considered safe in pregnancy; avoid use.
Breastfeeding Avoid Cannabinoids can pass into breast milk, so avoid CBG while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naldemedine Tosylate and Cannabigerol (cbg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Naldemedine Tosylate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Naldemedine Tosylate is filed under 3 classifications — p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Cannabigerol (cbg) has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Naldemedine Tosylate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cannabigerol (cbg) Does Interact With Other Medications

Cannabigerol (cbg) has 172 moderate known drug interactions in our database — Naldemedine Tosylate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Naldemedine Tosylate)
Taking anything else?

Check Another of Your Medications Against Cannabigerol (cbg)

Covers the 2,830 medications we’ve checked against Cannabigerol (cbg). Pick one to open its full report.

What to actually watch for

What Naldemedine Tosylate’s Own FDA Label Lists

This is not an interaction — none of it involves Cannabigerol (cbg). These are the most notable effects listed in the ADVERSE REACTIONS section of Naldemedine Tosylate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on
  • An allergic reaction Worth acting on
  • Chills
  • Tremor or shakiness
  • Flushing
  • Sweating
  • A fast or pounding heartbeat
  • Anxiety or restlessness
  • Stomach upset
  • Fever

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Naldemedine Tosylate. Read the label on DailyMed › Cannabigerol (cbg)’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cannabigerol (cbg) side to compare — that is a limit of the record, not a statement that Cannabigerol (cbg) has no side effects.

Everything else you take

See Every Supplement That Interacts With Naldemedine Tosylate

This page covers Cannabigerol (cbg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naldemedine Tosylate page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 103 moderate · 38 minor.

From our pharmacist’s overview on the Naldemedine Tosylate page

“Naldemedine (Symproic) relieves constipation caused by opioid painkillers, and this list of 144 supplements deserves real attention, starting with the three rated major: grapefruit, St. John's wort, and activated charcoal.”

Reviewed by 2 · Jul 18, 2026

Open the Naldemedine Tosylate interaction page

How much people look this up

Where Cannabigerol (cbg) and Naldemedine Tosylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabigerol (cbg)
Top half

#709 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naldemedine Tosylate
Top 10%

#197 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabigerol (cbg) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Cannabigerol (cbg) and Naldemedine Tosylate records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabigerol (cbg)

What is Cannabigerol (cbg)?

  • Anxiety and stress
  • Pain and inflammation
  • Sleep support
  • Focus and mood
  • Digestive discomfort

Cannabigerol (CBG) is a minor cannabinoid from the cannabis (hemp) plant that is marketed for anxiety, pain, and inflammation, but human research is very limited and most claims rest on laboratory and animal studies. It appears to be generally well tolerated in early reports, but its long-term safety, quality, and dosing are not well established. Talk to your pharmacist or doctor before trying it, especially if you take other medicines or are pregnant or breastfeeding.

Cannabis sativa · Cannabaceae · Flowers and aerial parts (extracted cannabinoid) · Oils and tinctures, capsules, gummies, vapes, topicals

An interaction check asks whether these two react with each other — it does not ask whether Cannabigerol (cbg) is a good idea for someone in your situation. Here is what our Cannabigerol (cbg) record says about it on its own.

Cannabigerol (cbg): dosing

There is no established, standardized dose for CBG. Because human research is so limited, experts have not defined how much to take, how often, or for how long.If you and your healthcare provider decide to try it, follow the directions on the product label and consider starting with the lowest suggested amount. Do not assume that more is better.

From our Cannabigerol (cbg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabigerol (cbg) monograph & all interactions
Medication

About Naldemedine

What Is Naldemedine Used For?

Brand name: Symproic

Naldemedine (sold as Symproic tablets) treats opioid-induced constipation (OIC). That is constipation caused by taking opioid pain medicine.

It is for adults with chronic non-cancer pain. This includes people with long-term pain related to prior cancer or its treatment who do not need frequent (for example, weekly) increases in their opioid dose.

See full Naldemedine drug information
Keep checking

Other Drugs & Cannabigerol (cbg)

Browse every other medication we’ve checked against Cannabigerol (cbg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Cannabigerol (cbg) page.

No interaction 2,657 drugs checked — show the list

We also checked Cannabigerol (cbg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Cannabigerol (cbg) list.

See the full Cannabigerol (cbg) interactions page
See every supplement checked against Naldemedine Tosylate, ranked by severity
Evidence & sources

Cannabigerol (cbg) References

The 1 references that drive our Cannabigerol (cbg) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Vernail VL, Bingaman SS, Silberman Y, Raup-Konsavage WM, Vrana KE, Arnold AC. Acute cannabigerol administration lowers blood pressure in mice. Front Physiol 2022;13:871962. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabigerol (cbg) and Naldemedine Tosylate Together: Common Questions

Is it safe to take Cannabigerol (cbg) with Naldemedine Tosylate?
We do not list a known interaction between Cannabigerol (cbg) and Naldemedine Tosylate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Cannabigerol (cbg) and Naldemedine Tosylate combination checked?
Interactions in our licensed database are recorded against drug classes. Naldemedine Tosylate is filed under 3 classifications, and Cannabigerol (cbg) has documented interactions with 1 drug class — none of Naldemedine Tosylate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cannabigerol (cbg) interact with any other medications?
Yes. Cannabigerol (cbg) has 172 documented drug interactions in our database — Naldemedine Tosylate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Naldemedine Tosylate interact with any supplements?
Yes. Naldemedine Tosylate has documented interactions with 144 supplements in our database — Cannabigerol (cbg) is not one of them. The Naldemedine Tosylate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cannabigerol (cbg) monograph Uses, safety profile, and every drug interaction in one place Naldemedine drug information The full plain-English guide to this medication Naldemedine Tosylate supplement interactions Every supplement checked against Naldemedine Tosylate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naldemedine Tosylate and Cannabigerol (cbg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.