Drug & supplement interaction

Casein Peptides + Ingenol Mebutate

Ingenol Mebutate brand name: Picato.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Casein Peptides and Ingenol Mebutate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Casein Peptides and Ingenol Mebutate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ingenol Mebutate and Casein Peptides in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Casein Peptides safety at a glance

Casein Peptides overall Use caution Generally well tolerated in healthy adults, but people with milk allergy should avoid them.

Pregnancy Use caution Not enough reliable safety data, so it is best to avoid concentrated supplements unless advised by your doctor.

Breastfeeding Use caution Safety of supplement doses is not well studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ingenol Mebutate and Casein Peptides? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Ingenol Mebutate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ingenol Mebutate is filed under a single classification — topical drugs. Casein Peptides has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Ingenol Mebutate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Casein Peptides Does Interact With Other Medications

Casein Peptides has 172 moderate known drug interactions in our database — Ingenol Mebutate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Ingenol Mebutate)

Taking anything else?

Check Another of Your Medications Against Casein Peptides

Covers the 2,830 medications we’ve checked against Casein Peptides. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ingenol Mebutate

This page covers Casein Peptides only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ingenol Mebutate page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Ingenol Mebutate page

“Ingenol mebutate (Picato) is a gel applied to the skin for actinic keratosis, the rough precancerous patches caused by sun damage, and it is deliberately harsh, producing redness, flaking, and stinging as part of how it works. The few supplement interactions on record are all skin-level ones.”

Reviewed by 2 · Jul 18, 2026

Open the Ingenol Mebutate interaction page

One more smart check

Taking Casein Peptides as Part of a Dietary Supplement Product? Check It for Interactions

We hold 82 real supplement products containing Casein Peptides, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Casein Peptides. Even though Casein Peptides itself has no known interaction with Ingenol Mebutate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Casein Peptides and Ingenol Mebutate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Casein Peptides

Steady interest

#1,003 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Ingenol Mebutate

Steady interest

#1,608 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Casein Peptides reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Casein Peptides and Ingenol Mebutate records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Casein Peptides

What is Casein Peptides?

High blood pressure
Stress and relaxation
Sleep support
General wellness/protein supplement

Casein peptides are small protein fragments made from milk casein, often studied for mild blood pressure support and relaxation. The evidence is limited and mostly modest, so they should not replace proven treatments. People with milk allergy should avoid them, and anyone with a health condition should check with a pharmacist or doctor first.

Casein protein from milk (cow's milk) · Capsules, tablets, powders, functional foods and drinks

An interaction check asks whether these two react with each other — it does not ask whether Casein Peptides is a good idea for someone in your situation. Here is what our Casein Peptides record says about it on its own.

Casein Peptides: dosing

There is no official or standardized dose of casein peptides. The amounts used in studies have varied widely depending on the specific peptide and product, and there is no single agreed-upon effective dose.If you choose to use a casein peptide product, follow the directions on the label and do not exceed the recommended amount. They can help you decide whether the product is appropriate and which form makes sense for you.

From our Casein Peptides monograph — the full record covers uses, side effects and every documented interaction.

Read the full Casein Peptides monograph & all interactions

Medication

About Ingenol Mebutate Topical

What Is Ingenol Mebutate Topical Used For?

Brand name: Picato

Ingenol mebutate gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.

See full Ingenol Mebutate Topical drug information

Keep checking

Other Drugs & Casein Peptides

Browse every other medication we’ve checked against Casein Peptides — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

172Moderate

0Minor

2,657No known interaction

172 Moderate 2,657 No interaction

Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Casein Peptides page.

No interaction 2,657 drugs checked — show the list

We also checked Casein Peptides against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Casein Peptides list.

See the full Casein Peptides interactions page

See every supplement checked against Ingenol Mebutate, ranked by severity

Evidence & sources

Casein Peptides References

The 4 references that drive our Casein Peptides monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Cicero AFG, Aubin F, Azais-Braesco V, Borghi C. Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials. Am J Hypertens. 2013;26(3): PubMed
Fekete AA, Givens DA, Lovegrove JA. Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials. Nutrients. 2015;7(1):659-81. PubMed
Qin LQ, Xu JY, Dong JY, Zhao Y, van Bladeren P, Zhang W. Lactotripeptides intake and blood pressure management: a meta-analysis of randomised controlled clinical trials. Nutr Metab Cardiovasc Dis. 2013;23(5):395-402. PubMed
Turpeinen AM, Järvenpää S, Kautiainen H, Korpela R, Vapaatalo H. Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis. Ann Med. 2013;45(1):51-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Casein Peptides and Ingenol Mebutate Together: Common Questions

Is it safe to take Casein Peptides with Ingenol Mebutate?

We do not list a known interaction between Casein Peptides and Ingenol Mebutate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Casein Peptides and Ingenol Mebutate combination checked?

Interactions in our licensed database are recorded against drug classes. Ingenol Mebutate is filed under 1 classification, and Casein Peptides has documented interactions with 1 drug class — none of Ingenol Mebutate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Casein Peptides interact with any other medications?

Yes. Casein Peptides has 172 documented drug interactions in our database — Ingenol Mebutate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Ingenol Mebutate interact with any supplements?

Yes. Ingenol Mebutate has documented interactions with 3 supplements in our database — Casein Peptides is not one of them. The Ingenol Mebutate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Casein Peptides monograph Uses, safety profile, and every drug interaction in one place Ingenol Mebutate Topical drug information The full plain-English guide to this medication Ingenol Mebutate supplement interactions Every supplement checked against Ingenol Mebutate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ingenol Mebutate and Casein Peptides?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.