Drug & supplement interaction

Corn Silk + Methylergonovine Maleate

Methylergonovine Maleate brand name: Methergine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Corn Silk and Methylergonovine Maleate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Corn Silk and Methylergonovine Maleate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methylergonovine Maleate and Corn Silk in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corn Silk safety at a glance

Corn Silk overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Possibly Safe When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methylergonovine Maleate and Corn Silk? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methylergonovine Maleate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methylergonovine Maleate is filed under 2 classifications — ergot derivatives, oral drugs. Corn Silk has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and corticosteroids (moderate) — and none of Methylergonovine Maleate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corn Silk Does Interact With Other Medications

Corn Silk has 290 moderate known drug interactions in our database — Methylergonovine Maleate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 290 No known interaction 2,540 (incl. Methylergonovine Maleate)
Taking anything else?

Check Another of Your Medications Against Corn Silk

Covers the 2,830 medications we’ve checked against Corn Silk. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Corn Silk and Methylergonovine Maleate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Corn Silk

    “Topically, corn silk can cause dermatitis and urticaria (4).”

    Corn Silk · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Methylergonovine Maleate

    Listed in the ADVERSE REACTIONS section of the FDA label for Methylergonovine Maleate. Read the label on DailyMed ›

Reported for Corn Silk but not commonly for Methylergonovine Maleate: low sodium, low potassium and hives.

Effects for Methylergonovine Maleate come from the ADVERSE REACTIONS section of its FDA label; effects for Corn Silk come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Corn Silk in Pregnancy & Breastfeeding

Lactation Possibly Safe

When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Methylergonovine Maleate

This page covers Corn Silk only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylergonovine Maleate page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), Ephedra (moderate), Ergot (moderate) and European Mandrake (moderate).

By severity: 1 major · 10 moderate · 9 minor.

From our pharmacist’s overview on the Methylergonovine Maleate page

“Methylergonovine (Methergine) has one short, serious job, controlling uterine bleeding after childbirth, so the 20 supplement interactions on file deserve real attention, not a shrug. Seventeen involve fibers, gums, and charcoals that can change how much of an oral dose is absorbed, and the one major-rated entry, activated charcoal, ca…”

Reviewed by 2 · Jul 18, 2026

Open the Methylergonovine Maleate interaction page

One more smart check

Taking Corn Silk as Part of a Dietary Supplement Product? Check It for Interactions

We hold 58 real supplement products containing Corn Silk, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Corn Silk. Even though Corn Silk itself has no known interaction with Methylergonovine Maleate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Corn Silk and Methylergonovine Maleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corn Silk
Top half

#483 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methylergonovine Maleate
Steady interest

#2,263 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corn Silk reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Corn Silk and Methylergonovine Maleate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Corn Silk

What is Corn Silk?

Corn Silk
  • Urinary tract and bladder problems
  • Mild fluid retention (diuretic)
  • Kidney and prostate concerns
  • Bedwetting in children
  • Soothing urinary irritation

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should not replace proven treatments. It is generally considered low-risk for short-term use in healthy adults, but talk with your pharmacist or doctor before trying it.

Zea mays · Poaceae · Stigmas and styles (the silky strands) of the corn ear · Tea, dried herb, liquid extract/tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Corn Silk is a good idea for someone in your situation. Here is what our Corn Silk record says about it on its own.

Corn Silk: dosing

There is no official, standardized dose for corn silk. It has traditionally been taken as a tea made by steeping dried corn silk in hot water, or as a liquid extract or capsule.Because product strengths vary widely, the best advice is to follow the directions on the product label and not exceed them.

From our Corn Silk monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corn Silk monograph & all interactions
Medication

About Methylergonovine

What Is Methylergonovine Used For?

Brand name: Methergine

Methylergonovine is used after delivery to manage uterine atony (a uterus that isn't contracting firmly enough), hemorrhage (heavy bleeding), and subinvolution (when the uterus is slow to return to its normal size). It is also used to control uterine hemorrhage during the second stage of labor after delivery of the anterior shoulder.

Both the tablet (brands: Methergine, Methylergonovine Maleate) and the injection (Methylergonovine Maleate) share these indications. The injection is given in a hospital setting by healthcare providers; the tablet may be continued at home during the postpartum period.

See full Methylergonovine drug information
Keep checking

Other Drugs & Corn Silk

Browse every other medication we’ve checked against Corn Silk — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
290Moderate
0Minor
2,539No known interaction
290 Moderate 2,539 No interaction
Moderate

290 interactions

Showing 60 of 290 moderate interactions — see all 290 on the Corn Silk page.

No interaction 2,539 drugs checked — show the list

We also checked Corn Silk against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,539 medications checked with no known interaction — see the full Corn Silk list.

See the full Corn Silk interactions page
See every supplement checked against Methylergonovine Maleate, ranked by severity
Evidence & sources

Corn Silk References

The 4 references that drive our Corn Silk monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
  4. Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corn Silk and Methylergonovine Maleate Together: Common Questions

Is it safe to take Corn Silk with Methylergonovine Maleate?
We do not list a known interaction between Corn Silk and Methylergonovine Maleate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Corn Silk and Methylergonovine Maleate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Corn Silk and Methylergonovine Maleate combination checked?
Interactions in our licensed database are recorded against drug classes. Methylergonovine Maleate is filed under 2 classifications, and Corn Silk has documented interactions with 5 drug classes — none of Methylergonovine Maleate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Corn Silk interact with any other medications?
Yes. Corn Silk has 290 documented drug interactions in our database — Methylergonovine Maleate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methylergonovine Maleate interact with any supplements?
Yes. Methylergonovine Maleate has documented interactions with 20 supplements in our database — Corn Silk is not one of them. The Methylergonovine Maleate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corn Silk monograph Uses, safety profile, and every drug interaction in one place Methylergonovine drug information The full plain-English guide to this medication Methylergonovine Maleate supplement interactions Every supplement checked against Methylergonovine Maleate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methylergonovine Maleate and Corn Silk?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.