Garcinia - Amitriptyline, Chlordiazepoxide Interaction
Herbal: Garcinia
Also Known As: Garcinia gummi-gutta, Acide Hydroxycitrique, AHC, Brindal Berry, Brindle Berry, Gorikapuli, HCA, Hydroxycitrate, Hydroxycitric Acid, Kankusta, Kudam puli, Malabar Tamarind, Tamarinier de Malabar, Vrikshamla
Drug: Amitriptyline, Chlordiazepoxide
Brand names:
Limbitrol DS
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Amitriptyline, Chlordiazepoxide is classified as belonging to the following category: Serotonergic Drugs
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print].
Garcinia Overview
Garcinia is a plant genus in the family Clusiaceae, and is native to Asia, Australia, tropical and southern Africa, and Polynesia. The most well-known species is Garcinia cambogia, which is native to Indonesia. Garcinia cambogia is rich in hydroxycitric acid (HCA), which is thought to be the main active component responsible for its purported medicinal effects of promoting weight loss and appetite suppression.
Garcinia - More Interactions
Garcinia interacts with 672 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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