Drug & supplement interaction

Griffonia Simplicifolia + Amitriptyline

Amitriptyline brand name: Elavil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Amitriptyline falls into 2 drug categories that Griffonia Simplicifolia can interact with; the most serious is rated moderate. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Griffonia Simplicifolia and Amitriptyline

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Griffonia Simplicifolia interacts with whole categories of medication. Amitriptyline falls into 2 of those categories, so it can interact with Griffonia Simplicifolia in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CNS DEPRESSANTS

1 of 2

Why this applies to Amitriptyline

Amitriptyline falls under CNS DEPRESSANTS — the group Griffonia Simplicifolia interacts with.

Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.
Griffonia simplicifolia seed extract contains 5-HTP. In clinical trials, 5-HTP has been associated with drowsiness and somnolence.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with this pair. Amitriptyline already tends to make people feel sleepy and a bit foggy, which is one reason it's often taken at night. Griffonia seed extract supplies 5-HTP, and in studies that compound has also been linked to drowsiness. Put the two together and those calming, sedating effects can stack on top of each other.

So what could you actually notice? More daytime grogginess, trouble concentrating, or feeling slowed down. This concern is mostly theoretical, based on how the two work rather than on solid head-to-head studies, so I don't want to alarm you. Since amitriptyline also nudges serotonin upward, please run this past your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
  2. den Boer JA, Westenberg HG. Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 1990;31:267-78. PubMed
  3. Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25:327-9. PubMed
  4. De Benedittis G, Massei R. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo. J Neurosurg Sci 1985;29:239-48.
  5. Lemaire PA, Adosraku RK. An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia. Phytochem Anal 2002;13(6):333-7.
Moderate

ANTIDEPRESSANT DRUGS

2 of 2

Amitriptyline also falls under ANTIDEPRESSANT DRUGS.

Theoretically, taking Griffonia simplicifolia seed extract with antidepressant drugs might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Griffonia simplicifolia seed extract contains 5-HTP. Taking 5-HTP with antidepressant drugs increases the risk of serotonergic adverse effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing Griffonia with your amitriptyline (Elavil). Griffonia seeds are rich in 5-HTP, which your body turns into serotonin. Amitriptyline already raises serotonin levels in the brain as part of how it treats depression. Stacking the two means you could end up with too much serotonin activity at once.

When serotonin gets too high, you can run into what's called serotonin syndrome. Watch for things like agitation, a racing heart, sweating, shivering, muscle twitching, or confusion. To be clear, this concern is theoretical, based on how both work rather than lots of real cases, so I don't want to scare you. Still, since both push serotonin the same direction, please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Lemaire PA, Adosraku RK. An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia. Phytochem Anal 2002;13(6):333-7.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Griffonia Simplicifolia Also Interacts With Other Medications

Griffonia Simplicifolia has 316 moderate known drug interactions in our database — the Amitriptyline one above is among them. If you take anything else, check it against the full list below.

Moderate 316 No known interaction 2,514 (incl. Amitriptyline)
Taking anything else?

Check Another of Your Medications Against Griffonia Simplicifolia

Covers the 2,830 medications we’ve checked against Griffonia Simplicifolia. Pick one to open its full report.

From our Q&A

Questions About Griffonia Simplicifolia or Amitriptyline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Griffonia Simplicifolia or Amitriptyline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amitriptyline

This page covers Griffonia Simplicifolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amitriptyline page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 17 major · 228 moderate · 51 minor.

From our pharmacist’s overview on the Amitriptyline page

“Amitriptyline (Elavil), an older antidepressant now often prescribed for nerve pain, migraines, and sleep, is one of the drugs I genuinely want patients to be careful with, and 17 of the 296 supplement and herbal ingredients on this list carry a major rating. Most of the serious ones deepen the drowsiness amitriptyline already causes,…”

Reviewed by 2 · Jul 18, 2026

Open the Amitriptyline interaction page

One more smart check

Taking Griffonia Simplicifolia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Griffonia Simplicifolia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Griffonia Simplicifolia. Your product may carry other ingredients that interact with Amitriptyline too, on top of Griffonia Simplicifolia — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Griffonia Simplicifolia and Amitriptyline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Griffonia Simplicifolia
Top half

#637 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amitriptyline
Top 5%

#45 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Griffonia Simplicifolia

What is Griffonia Simplicifolia?

Griffonia Simplicifolia
  • Low mood
  • Sleep problems
  • Anxiety
  • Appetite control
  • Headaches

Griffonia simplicifolia is a West African shrub whose seeds are a natural source of 5-HTP, a building block of the brain chemical serotonin. Some people use it for mood, sleep, and appetite, but high-quality human evidence is limited, and it should not replace prescribed treatment. Talk with your pharmacist or doctor before using it, especially if you take medicines that affect serotonin.

Read the full Griffonia Simplicifolia monograph & all interactions
Medication

About Amitriptyline

What Is Amitriptyline Used For?

Brand name: Elavil

Amitriptyline HCL and Amitriptyline Hydrochloride tablets are used to relieve symptoms of depression. Depression that originates from within the body (called endogenous depression) tends to respond better than other types of depression.

See full Amitriptyline drug information
Keep checking

Other Drugs & Griffonia Simplicifolia

Browse every other medication we’ve checked against Griffonia Simplicifolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
316Moderate
0Minor
2,513No known interaction
316 Moderate 2,513 No interaction
Moderate

316 interactions

Showing 60 of 316 moderate interactions — see all 316 on the Griffonia Simplicifolia page.

No interaction 2,513 drugs checked — show the list

We also checked Griffonia Simplicifolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,513 medications checked with no known interaction — see the full Griffonia Simplicifolia list.

See the full Griffonia Simplicifolia interactions page
See every supplement checked against Amitriptyline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Griffonia Simplicifolia monograph › Uses, safety, and every drug interaction in one place Amitriptyline supplement interactions › Every supplement checked against Amitriptyline, ranked by severity Amitriptyline drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Griffonia Simplicifolia and Amitriptyline Together: Common Questions

Can you take Griffonia Simplicifolia with Amitriptyline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Griffonia Simplicifolia and Amitriptyline?
Amitriptyline belongs to more than one drug category, and Griffonia Simplicifolia interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Griffonia Simplicifolia and Amitriptyline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.