Drug & supplement interaction

Hoodia + Fentanyl

Fentanyl brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hoodia and Fentanyl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Hoodia and Fentanyl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fentanyl and Hoodia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hoodia safety at a glance

Hoodia overall Use caution Limited safety data exist, and side effects and product quality concerns have been reported.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid There is not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fentanyl and Hoodia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fentanyl

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fentanyl is filed under 10 classifications — including narcotic drugs, serotonergic drugs, serotonergic drugs. Hoodia has documented interactions with 4 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and beta-blockers (moderate) — and none of Fentanyl’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hoodia Does Interact With Other Medications

Hoodia has 262 moderate known drug interactions in our database — Fentanyl isn’t one of them. If you take anything else, check it against the full list below.

Moderate 262 No known interaction 2,568 (incl. Fentanyl)
Taking anything else?

Check Another of Your Medications Against Hoodia

Covers the 2,830 medications we’ve checked against Hoodia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hoodia and Fentanyl May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness / Headache Additional detail

    Hoodia

    “Orally, hoodia has been reported to cause minor adverse effects including disturbances of skin sensation, headache, dizziness, giddiness, and nausea. There is also concern that hoodia may increase blood pressure and heart rate.”

    Hoodia · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18052. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed

    “Orally, hoodia extract has been reported to cause headache, dizziness, and giddiness.”

    Hoodia · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18052. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed ›

  • Nausea reported in 5.0% of FDA reports for Fentanyl Additional detail

    Hoodia

    “Orally, hoodia extract has been reported to cause nausea.”

    Hoodia · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18052. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed

    Fentanyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Fentanyl, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Fentanyl come from the ADVERSE REACTIONS section of its FDA label; effects for Hoodia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 114,883 voluntary FDA FAERS reports for Fentanyl that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Hoodia or Fentanyl

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hoodia or Fentanyl, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fentanyl

This page covers Hoodia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fentanyl page lists 226 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 10 major · 176 moderate · 40 minor.

From our pharmacist’s overview on the Fentanyl page

“There is very little room for error with fentanyl (Duragesic, Sublimaze, Actiq, and other forms), a powerful opioid where a modest rise in blood level or an extra layer of sedation can become dangerous, so this interaction list deserves real respect. Most of the risk falls into two patterns.”

Reviewed by 2 · Jul 18, 2026

Open the Fentanyl interaction page

One more smart check

Taking Hoodia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 283 real supplement products containing Hoodia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hoodia. Even though Hoodia itself has no known interaction with Fentanyl, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hoodia and Fentanyl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hoodia
Top half

#386 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fentanyl
Top 25%

#565 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hoodia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hoodia and Fentanyl records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hoodia

What is Hoodia?

Hoodia
  • Appetite suppression
  • Weight loss
  • Reducing food cravings
  • Traditional use for hunger and thirst on long journeys

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actually works is lacking. The few quality studies done have not shown meaningful weight loss, and some products on the market may not even contain real hoodia. Talk with your pharmacist or doctor before trying it, and avoid it if you are pregnant or breastfeeding.

Hoodia gordonii · Apocynaceae · Stem (aerial parts) · Capsules, tablets, powders, liquid extracts, teas, chews

An interaction check asks whether these two react with each other — it does not ask whether Hoodia is a good idea for someone in your situation. Here is what our Hoodia record says about it on its own.

Hoodia: dosing

There is no established, well-studied dose for hoodia. Products vary widely in their strength, purity, and how they are made, and some may not contain genuine hoodia at all.If you choose to try a hoodia supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Hoodia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hoodia monograph & all interactions
Medication

About Fentanyl

What Is Fentanyl Used For?

Brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, Subsys

Fentanyl transdermal system is prescribed for severe, persistent pain that cannot be controlled with other pain medicines, including shorter-acting opioids. It is only for people who are already opioid-tolerant — meaning they've been taking a significant daily opioid dose for at least a week.

It is not for short-term pain, post-surgical pain, mild pain, or use on an as-needed basis. Because of serious risks including addiction, overdose, and death, it is reserved for situations where other treatment options have failed or are not appropriate.

Most-Reported Side Effects for Fentanyl

From FAERS, the FDA’s public side-effect reporting system (114,883 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug abuse 12,447 reports
Overdose 8,162 reports
Toxicity to various agents 7,374 reports
Drug dependence 6,445 reports
Nausea 5,689 reports
See full Fentanyl drug information
Keep checking

Other Drugs & Hoodia

Browse every other medication we’ve checked against Hoodia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
262Moderate
0Minor
2,567No known interaction
262 Moderate 2,567 No interaction
Moderate

262 interactions

Showing 60 of 262 moderate interactions — see all 262 on the Hoodia page.

No interaction 2,567 drugs checked — show the list

We also checked Hoodia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,567 medications checked with no known interaction — see the full Hoodia list.

See the full Hoodia interactions page
See every supplement checked against Fentanyl, ranked by severity
Evidence & sources

Hoodia References

The 3 references that drive our Hoodia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed
  2. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059.
  3. Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hoodia and Fentanyl Together: Common Questions

Is it safe to take Hoodia with Fentanyl?
We do not list a known interaction between Hoodia and Fentanyl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hoodia and Fentanyl have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Hoodia and Fentanyl combination checked?
Interactions in our licensed database are recorded against drug classes. Fentanyl is filed under 10 classifications, and Hoodia has documented interactions with 4 drug classes — none of Fentanyl's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hoodia interact with any other medications?
Yes. Hoodia has 262 documented drug interactions in our database — Fentanyl is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fentanyl interact with any supplements?
Yes. Fentanyl has documented interactions with 226 supplements in our database — Hoodia is not one of them. The Fentanyl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hoodia monograph Uses, safety profile, and every drug interaction in one place Fentanyl drug information The full plain-English guide to this medication Fentanyl supplement interactions Every supplement checked against Fentanyl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fentanyl and Hoodia?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.