Drug & supplement interaction

Inositol Nicotinate + Aspirin, Caffeine, Dihydrocodeine Bitartrate

Aspirin, Caffeine, Dihydrocodeine Bitartrate brand name: Synalgos DC.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Inositol Nicotinate has a moderate interaction with Aspirin, Caffeine, Dihydrocodeine Bitartrate. Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Inositol Nicotinate and Aspirin, Caffeine, Dihydrocodeine Bitartrate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Aspirin, Caffeine, Dihydrocodeine Bitartrate

Aspirin, Caffeine, Dihydrocodeine Bitartrate falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Inositol Nicotinate interacts with.

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Inositol nicotinate has fibrinolytic effects, which may increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep an eye on: your Synalgos DC product contains aspirin, which already thins the blood a bit by making platelets less sticky. Inositol nicotinate (a 'no-flush' niacin) is thought to have mild clot-busting (fibrinolytic) activity, so pairing the two could theoretically nudge your bleeding risk a little higher.

In real life that might look like easier bruising, nosebleeds, bleeding gums, or a cut that's slow to stop. I want to be honest, though: this concern is theoretical, based on how the ingredients work rather than strong studies, so don't panic. The dihydrocodeine and caffeine pieces aren't the issue here. Before combining them, just run it by your pharmacist or doctor, especially if you're on other blood thinners or have liver concerns.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. Holti G. An experimentally controlled evaluation of the effect of inositol nicotinate upon the digital blood flow in patients with Raynaud's phenomenon. J Int Med Res 1979;7:473-83. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Inositol Nicotinate Also Interacts With Other Medications

Inositol Nicotinate has 222 moderate known drug interactions in our database — the Aspirin, Caffeine, Dihydrocodeine Bitartrate one above is one of them. If you take anything else, check it against the full list below.

Moderate 222 No known interaction 2,608 (incl. Aspirin, Caffeine, Dihydrocodeine Bitartrate)
Taking anything else?

Check Another of Your Medications Against Inositol Nicotinate

Covers the 2,830 medications we’ve checked against Inositol Nicotinate. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Caffeine, Dihydrocodeine Bitartrate

This page covers Inositol Nicotinate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Dihydrocodeine Bitartrate page lists 398 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 17 major · 334 moderate · 47 minor.

Open the Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction page

One more smart check

Taking Inositol Nicotinate as Part of a Dietary Supplement Product? Check It for Interactions

We hold 202 real supplement products containing Inositol Nicotinate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Inositol Nicotinate. Your product may carry other ingredients that interact with Aspirin, Caffeine, Dihydrocodeine Bitartrate too, on top of Inositol Nicotinate — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Inositol Nicotinate and Aspirin, Caffeine, Dihydrocodeine Bitartrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Inositol Nicotinate
Top 25%

#332 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Caffeine, Dihydrocodeine Bitartrate
Top half

#1,095 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Inositol Nicotinate

What is Inositol Nicotinate?

Inositol Nicotinate
  • Cholesterol support
  • Improving circulation
  • Raynaud's phenomenon
  • Intermittent claudication (leg pain with walking)
  • A 'no-flush' niacin alternative

Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation. Evidence that it works as well as regular niacin is weak and inconsistent, and it is not a proven replacement for prescription cholesterol treatment. Talk to your pharmacist or doctor before using it, especially if you have liver problems or take other medicines.

Read the full Inositol Nicotinate monograph & all interactions
Keep checking

Other Drugs & Inositol Nicotinate

Browse every other medication we’ve checked against Inositol Nicotinate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
222Moderate
0Minor
2,607No known interaction
222 Moderate 2,607 No interaction
Moderate

222 interactions

Showing 60 of 222 moderate interactions — see all 222 on the Inositol Nicotinate page.

No interaction 2,607 drugs checked — show the list

We also checked Inositol Nicotinate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,607 medications checked with no known interaction — see the full Inositol Nicotinate list.

See the full Inositol Nicotinate interactions page
See every supplement checked against Aspirin, Caffeine, Dihydrocodeine Bitartrate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Inositol Nicotinate monograph › Uses, safety, and every drug interaction in one place Aspirin, Caffeine, Dihydrocodeine Bitartrate supplement interactions › Every supplement checked against Aspirin, Caffeine, Dihydrocodeine Bitartrate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Inositol Nicotinate and Aspirin, Caffeine, Dihydrocodeine Bitartrate Together: Common Questions

Can you take Inositol Nicotinate with Aspirin, Caffeine, Dihydrocodeine Bitartrate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Inositol Nicotinate and Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Caffeine, Dihydrocodeine Bitartrate and Inositol Nicotinate?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.