Drug & supplement interaction

Manganese + Risedronate

Risedronate brand name: Actonel DR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Manganese and Risedronate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Manganese and Risedronate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Risedronate and Manganese in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manganese safety at a glance

Manganese overall Use caution Safe in normal dietary amounts, but high-dose supplements can be harmful.
Pregnancy Use caution Amounts in foods and prenatal vitamins are appropriate, but avoid extra high-dose supplements unless advised.
Breastfeeding Likely Safe When used orally and appropriately. Manganese is safe when used in doses below the tolerable upper intake level (UL) of 11 mg daily during pregnancy or lactatio... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Risedronate and Manganese? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Risedronate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Risedronate is filed under 2 classifications — bisphosphonates, oral drugs. Manganese has documented interactions with 3 drug classes — the most serious being antipsychotic drugs (moderate), quinolone antibiotics (moderate) and tetracycline antibiotics (moderate) — and none of Risedronate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Manganese Does Interact With Other Medications

Manganese has 83 moderate known drug interactions in our database — Risedronate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 83 No known interaction 2,747 (incl. Risedronate)
Taking anything else?

Check Another of Your Medications Against Manganese

Covers the 2,830 medications we’ve checked against Manganese. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Manganese and Risedronate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on Additional detail

    Manganese

    “Chronic occupational exposure to manganese dust or fumes has been associated with lower bone quality in females, but not males, suggesting that prolonged manganese exposure might increase the risk of osteoporosis in females. A meta-analysis of 11 observational studies in adults also suggests that increased environmental exposure to airborne manganese sources is associated with lower motor function scores.”

    Manganese · Natural Medicines adverse-effect record, reported in bone loss.

    2 sources cited
    1. 102516. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
    2. 108537. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

  • Low mood Worth acting on Additional detail

    Manganese

    “Chronic occupational exposure to manganese dust or fumes can cause mood disturbance and dementia. A case report describes a man who presented with confusion, psychosis, dystonic limb movements, and cognitive impairment after chronic industrial manganese exposure.”

    Manganese · Natural Medicines adverse-effect record, reported in cognitive impairment.

    4 sources cited
    1. 1990. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
    2. 7135. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
    3. 99415. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
    4. 108536. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Manganese

    “Manganese intoxication may cause cirrhosis and hepatic steatosis. In one case, a 13-year-old female with manganese intoxication developed severe, life-threatening neurological symptoms, with liver biopsy indicating incomplete cirrhosis and microvesicular steatosis. Chelation therapy and multiple rounds of therapeutic plasma exchange were required before symptoms resolved.”

    Manganese · Natural Medicines adverse-effect record, reported in alcohol-related liver disease.

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

  • Swelling Additional detail

    Manganese

    “Chronic occupational exposure to manganese dust or fumes can cause acute chemical pneumonitis, pulmonary edema, or acute tracheobronchitis.”

    Manganese · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    1 source cited
    1. 61495. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

  • Tiredness Additional detail

    Manganese

    Recorded for Manganese in the same Natural Medicines adverse-effect record shown under Low mood above.

    Risedronate

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate. Read the label on DailyMed ›

Reported for Manganese but not commonly for Risedronate: low blood pressure, fainting, memory problems and muscle weakness.

Effects for Risedronate come from the ADVERSE REACTIONS section of its FDA label; effects for Manganese come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Manganese in Pregnancy & Breastfeeding

Lactation Likely Safe

When used orally and appropriately. Manganese is safe when used in doses below the tolerable upper intake level (UL) of 11 mg daily during pregnancy or lactation in those aged 19 or older. However, those under 19 years of age should limit doses to less than 9 mg daily.

Lactation Possibly Unsafe

When used orally in excessive doses. Doses over the UL are associated with a greater risk of toxicity. Additionally, observational research shows that adults with higher blood manganese levels have greater odds of delivering low birth weight or small for gestational age (SGA) male, but not female, infants.

Lactation Likely Unsafe

When inhaled at moderate doses, long-term. Manganese salts can cross the placenta, and animal research suggests that large amounts of manganese may be teratogenic.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Risedronate Is Prescribed For, and What Manganese Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Risedronate is a prescription medicine with approved uses on its FDA label. Manganese is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Risedronate is prescribed for: Risedronate sodium tablets are used to treat and prevent osteoporosis in postmenopausal women, treat osteoporosis in men to increase bone mass, and treat and prevent osteoporosis caused by long-term steroid (glucocorticoid) use in both men and women. They are also used to treat Paget's disease of bone — a condition where bones break down and rebuild abnormally, becoming enlarged and weakened. Risedronate sodium delayed-release tablets (brands Atelvia and Risedronate Sodium delayed-release) are approved specifically for the treatment of postmenopausal osteoporosis only — not for the other uses listed above.

Manganese has been studied for:

  • Osteoporosis studied, not established Manganese has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Manganese for osteoporosis

    Oral manganese has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Risedronate on your own; if you are taking Manganese for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Risedronate

This page covers Manganese only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Risedronate page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Calcium (moderate), Coffee Charcoal (moderate), Dolomite (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Risedronate page

“Risedronate (Actonel DR) is an osteoporosis medicine with an Achilles heel, poor absorption. Only a small fraction of each dose ever reaches the bone, and the 23 supplements on this page deserve genuine wariness because nearly all of them attack that weak point by binding or blunting the drug in the gut.”

Reviewed by 2 · Jul 18, 2026

Open the Risedronate interaction page

One more smart check

Taking Manganese as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16,006 real supplement products containing Manganese, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Manganese. Even though Manganese itself has no known interaction with Risedronate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Manganese and Risedronate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manganese
Top 5%

#18 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Risedronate
Steady interest

#2,555 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manganese reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Manganese and Risedronate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Manganese

What is Manganese?

Manganese
  • Bone health support
  • Antioxidant and enzyme support
  • Filling dietary gaps
  • Metabolism support
  • Wound healing

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements may help if you have a genuine deficiency, but too much can be harmful—especially to the nervous system—so do not take high doses without guidance from a pharmacist or doctor.

Mineral (dietary trace element) · Tablets, capsules, gummies, liquid drops, part of multivitamin/mineral and bone-health products

An interaction check asks whether these two react with each other — it does not ask whether Manganese is a good idea for someone in your situation. Here is what our Manganese record says about it on its own.

Manganese: dosing

There is no single "treatment dose" of manganese for most health goals. Health authorities have set recommended daily intakes for general nutrition and an upper limit that you should not exceed, because higher amounts increase the risk of harm.Most people meet their needs through food alone. If a supplement is recommended, the amount in a typical multivitamin or bone-health product is usually enough.

From our Manganese monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manganese monograph & all interactions
Medication

About Risedronate

What Is Risedronate Used For?

Brand name: Actonel DR

Risedronate sodium tablets are used to treat and prevent osteoporosis in postmenopausal women, treat osteoporosis in men to increase bone mass, and treat and prevent osteoporosis caused by long-term steroid (glucocorticoid) use in both men and women. They are also used to treat Paget's disease of bone — a condition where bones break down and rebuild abnormally, becoming enlarged and weakened.

Risedronate sodium delayed-release tablets (brands Atelvia and Risedronate Sodium delayed-release) are approved specifically for the treatment of postmenopausal osteoporosis only — not for the other uses listed above.

See full Risedronate drug information
Keep checking

Other Drugs & Manganese

Browse every other medication we’ve checked against Manganese — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
83Moderate
0Minor
2,746No known interaction
83 Moderate 2,746 No interaction
Moderate

83 interactions

Showing 60 of 83 moderate interactions — see all 83 on the Manganese page.

No interaction 2,746 drugs checked — show the list

We also checked Manganese against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,746 medications checked with no known interaction — see the full Manganese list.

See the full Manganese interactions page
See every supplement checked against Risedronate, ranked by severity
Evidence & sources

Manganese References

The 21 references that drive our Manganese monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manganese and Risedronate Together: Common Questions

Is it safe to take Manganese with Risedronate?
We do not list a known interaction between Manganese and Risedronate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Manganese and Risedronate have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Manganese and Risedronate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Manganese in each. That is a conversation for your prescriber, especially if Risedronate is being adjusted to a target.
How was the Manganese and Risedronate combination checked?
Interactions in our licensed database are recorded against drug classes. Risedronate is filed under 2 classifications, and Manganese has documented interactions with 3 drug classes — none of Risedronate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Manganese interact with any other medications?
Yes. Manganese has 83 documented drug interactions in our database — Risedronate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Risedronate interact with any supplements?
Yes. Risedronate has documented interactions with 23 supplements in our database — Manganese is not one of them. The Risedronate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manganese monograph Uses, safety profile, and every drug interaction in one place Risedronate drug information The full plain-English guide to this medication Risedronate supplement interactions Every supplement checked against Risedronate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Risedronate and Manganese?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.