Drug & supplement interaction

Marsh Labrador Tea + Sapropterin Dihydrochloride

Sapropterin Dihydrochloride brand name: Kuvan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Marsh Labrador Tea and Sapropterin Dihydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sapropterin Dihydrochloride states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Marsh Labrador Tea and Sapropterin Dihydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sapropterin Dihydrochloride and Marsh Labrador Tea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Marsh Labrador Tea safety at a glance

Marsh Labrador Tea overall Use caution The plant contains toxic grayanotoxins, so any internal use carries a risk of poisoning.
Pregnancy Likely Unsafe When used orally; avoid using. Marsh Labrador tea is considered to be a potential uterine stimulant and abortifacient. Read the full pregnancy detail
Breastfeeding Avoid Not enough safety data and it contains potentially toxic substances, so avoid use.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sapropterin Dihydrochloride and Marsh Labrador Tea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sapropterin Dihydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sapropterin Dihydrochloride is filed under a single classification — oral drugs. Marsh Labrador Tea has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Sapropterin Dihydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Marsh Labrador Tea Does Interact With Other Medications

Marsh Labrador Tea has 248 moderate known drug interactions in our database — Sapropterin Dihydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Sapropterin Dihydrochloride)
Taking anything else?

Check Another of Your Medications Against Marsh Labrador Tea

Covers the 2,830 medications we’ve checked against Marsh Labrador Tea. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Marsh Labrador Tea and Sapropterin Dihydrochloride May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Marsh Labrador Tea

    “Orally, large amounts of marsh Labrador tea can cause poisoning due to its ledol constituent (2). The essential oil of marsh Labrador tea can cause severe irritation of the gastrointestinal tract, vomiting, diarrhea, irritation and damage to the kidneys and urinary tract, heavy perspiration, myalgias, and arthralgias.”

    Marsh Labrador Tea · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 97164. Dampc A, Luczkiewicz M. Bog Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. J Sci Food Agric. 2015;95(8):1577-83. PubMed

    “Orally, ledol, a constituent of marsh Labrador tea essential oil, can cause central nervous system excitation in a dose-dependent manner. Small amounts of ledol can lead to mild stimulating effects similar to caffeine, while larger doses can lead to spasms, seizures, paralysis, and even death.”

    Marsh Labrador Tea · Natural Medicines adverse-effect record, reported in epilepsy.

    1 source cited
    1. 97164. Dampc A, Luczkiewicz M. Bog Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. J Sci Food Agric. 2015;95(8):1577-83. PubMed

    Sapropterin Dihydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Sapropterin Dihydrochloride. Read the label on DailyMed ›

  • Diarrhea / Vomiting reported in 4.9% of FDA reports for Sapropterin Dihydrochloride Additional detail

    Marsh Labrador Tea

    “Orally, ledol, a constituent of the essential oil of marsh Labrador tea, can cause gastrointestinal irritation resulting in vomiting, gastroenteritis, and diarrhea.”

    Marsh Labrador Tea · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 97164. Dampc A, Luczkiewicz M. Bog Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. J Sci Food Agric. 2015;95(8):1577-83. PubMed

    Sapropterin Dihydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Sapropterin Dihydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Marsh Labrador Tea but not commonly for Sapropterin Dihydrochloride: sweating.

Effects for Sapropterin Dihydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Marsh Labrador Tea come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 6,247 voluntary FDA FAERS reports for Sapropterin Dihydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Marsh Labrador Tea in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; avoid using. Marsh Labrador tea is considered to be a potential uterine stimulant and abortifacient.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Sapropterin Dihydrochloride Products Have a Food Rule — Marsh Labrador Tea Should Not Break It

At least one FDA label for a product containing Sapropterin Dihydrochloride says to take it with food. If you take Marsh Labrador Tea on an empty stomach out of habit, keep them separate — and take Sapropterin Dihydrochloride with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sapropterin Dihydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer KUVAN with a meal, preferably at the same time each day [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Sapropterin Dihydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sapropterin Dihydrochloride

This page covers Marsh Labrador Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sapropterin Dihydrochloride page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Sapropterin Dihydrochloride page

“Activated charcoal is the one entry on this page I would treat as a hard stop for anyone taking sapropterin dihydrochloride (Kuvan). It carries the list's only major rating because charcoal soaks up medications in the gut and can sharply cut how much of a dose actually reaches the bloodstream.”

Reviewed by 2 · Jul 18, 2026

Open the Sapropterin Dihydrochloride interaction page

How much people look this up

Where Marsh Labrador Tea and Sapropterin Dihydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Marsh Labrador Tea
Steady interest

#1,116 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sapropterin Dihydrochloride
Top half

#898 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Marsh Labrador Tea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Marsh Labrador Tea and Sapropterin Dihydrochloride records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Marsh Labrador Tea

What is Marsh Labrador Tea?

Marsh Labrador Tea
  • Colds and respiratory complaints
  • Cough and congestion
  • Mild aches and joint discomfort
  • Topical relief of skin irritation, swelling, and insect bites
  • Traditional use as a diuretic

Marsh Labrador tea is a bog-growing shrub used in folk medicine for coughs, colds, and skin problems, but high-quality human evidence for any use is lacking. Because it contains grayanotoxins (andromedotoxin) that can be poisonous, it is not considered safe for routine use, and pregnant or breastfeeding people should avoid it.

Rhododendron tomentosum · Ericaceae · Leaves and flowering twigs (and an essential oil distilled from them) · Tea (infusion), essential oil, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Marsh Labrador Tea is a good idea for someone in your situation. Here is what our Marsh Labrador Tea record says about it on its own.

Marsh Labrador Tea: dosing

There is no established safe or standardized dose for Marsh Labrador tea. Because the plant naturally contains toxic grayanotoxins, even traditional preparations carry risk, and stronger or longer brews increase that risk.If you choose to use a commercial product, follow the directions on the label exactly and do not exceed them. Never assume that "natural" means harmless.

From our Marsh Labrador Tea monograph — the full record covers uses, side effects and every documented interaction.

Read the full Marsh Labrador Tea monograph & all interactions
Medication

About Sapropterin

What Is Sapropterin Used For?

Brand name: Kuvan

Sapropterin is used to reduce elevated blood phenylalanine (Phe) levels in adults and children one month of age and older who have hyperphenylalaninemia (HPA) — high levels of the amino acid phenylalanine in the blood — caused by a form of PKU that responds to BH4. It works only in patients whose PKU responds to this treatment, which must be confirmed through a therapeutic trial.

All brands and formulations — including Kuvan, Javygtor, Zelvysia, and generic sapropterin dihydrochloride products — are approved for this same use. Sapropterin must always be used alongside a phenylalanine-restricted diet; it is not a replacement for dietary management.

See full Sapropterin drug information
Keep checking

Other Drugs & Marsh Labrador Tea

Browse every other medication we’ve checked against Marsh Labrador Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Marsh Labrador Tea page.

No interaction 2,581 drugs checked — show the list

We also checked Marsh Labrador Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Marsh Labrador Tea list.

See the full Marsh Labrador Tea interactions page
See every supplement checked against Sapropterin Dihydrochloride, ranked by severity
Evidence & sources

Marsh Labrador Tea References

The 3 references that drive our Marsh Labrador Tea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Dampc A, Luczkiewicz M. Bog Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. J Sci Food Agric. 2015;95(8):1577-83. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Marsh Labrador Tea and Sapropterin Dihydrochloride Together: Common Questions

Is it safe to take Marsh Labrador Tea with Sapropterin Dihydrochloride?
We do not list a known interaction between Marsh Labrador Tea and Sapropterin Dihydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Marsh Labrador Tea and Sapropterin Dihydrochloride have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Marsh Labrador Tea and Sapropterin Dihydrochloride at the same time of day?
At least one FDA label for a product containing Sapropterin Dihydrochloride says to take it with food. If you take Marsh Labrador Tea on an empty stomach out of habit, keep them separate and take Sapropterin Dihydrochloride with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sapropterin Dihydrochloride products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Marsh Labrador Tea and Sapropterin Dihydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Sapropterin Dihydrochloride is filed under 1 classification, and Marsh Labrador Tea has documented interactions with 1 drug class — none of Sapropterin Dihydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Marsh Labrador Tea interact with any other medications?
Yes. Marsh Labrador Tea has 248 documented drug interactions in our database — Sapropterin Dihydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sapropterin Dihydrochloride interact with any supplements?
Yes. Sapropterin Dihydrochloride has documented interactions with 17 supplements in our database — Marsh Labrador Tea is not one of them. The Sapropterin Dihydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Marsh Labrador Tea monograph Uses, safety profile, and every drug interaction in one place Sapropterin drug information The full plain-English guide to this medication Sapropterin Dihydrochloride supplement interactions Every supplement checked against Sapropterin Dihydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sapropterin Dihydrochloride and Marsh Labrador Tea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.